7A4C

Crystal structure of human protein kinase CK2alpha (CSNK2A1 gene product) in complex with the ATP-competitive inhibitor 5,6,7-tribromo-1H-triazolo[4,5-b]pyridine

Summary for 7A4C

Entry DOI	10.2210/pdb7a4c/pdb
Related	7A22 7A49
Descriptor	Casein kinase II subunit alpha, 5,6,7-tris(bromanyl)-1~{H}-[1,2,3]triazolo[4,5-b]pyridine, GLYCEROL, ... (5 entities in total)
Functional Keywords	protein kinase ck2, casein kinase 2, atp-competitive inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	81699.74
Authors	Niefind, K.,Lindenblatt, D.,Toelzer, C.,Bretner, M.,Chojnacki, K.,Wielechowska, M.,Winska, P. (deposition date: 2020-08-19, release date: 2020-12-09, Last modification date: 2024-01-31)
Primary citation	Chojnacki, K.,Lindenblatt, D.,Winska, P.,Wielechowska, M.,Toelzer, C.,Niefind, K.,Bretner, M. Synthesis, biological properties and structural study of new halogenated azolo[4,5-b]pyridines as inhibitors of CK2 kinase. Bioorg.Chem., 106:104502-104502, 2021 Cited by PubMed: 33317841 DOI: 10.1016/j.bioorg.2020.104502 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.502 Å)

Structure validation