7TBZ
 
 | | The structure of ABCA1 Y482C | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATP-binding cassette, ... | | 著者 | Sun, Y, Li, X. | | 登録日 | 2021-12-22 | | 公開日 | 2022-01-26 | | 最終更新日 | 2025-05-28 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Cholesterol efflux mechanism revealed by structural analysis of human ABCA1 conformational states.
Nat Cardiovasc Res, 1, 2022
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5W4A
 | | C. japonica N-domain | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, IMIDAZOLE, ... | | 著者 | Aoki, S.T, Bingman, C.A, Kimble, J. | | 登録日 | 2017-06-09 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | C. elegans germ granules require both assembly and localized regulators for mRNA repression.
Nat Commun, 12, 2021
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6N4L
 | | Dithionite-reduced ADP-bound form of the nitrogenase Fe-protein from A. vinelandii | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, IRON/SULFUR CLUSTER, MAGNESIUM ION, ... | | 著者 | Wenke, B.B, Spatzal, T, Rees, D.C. | | 登録日 | 2018-11-19 | | 公開日 | 2019-02-13 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Site-Specific Oxidation State Assignments of the Iron Atoms in the [4Fe:4S]2+/1+/0States of the Nitrogenase Fe-Protein.
Angew. Chem. Int. Ed. Engl., 58, 2019
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6MX1
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6GAO
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7ESL
 | | Crystal structure of a L-rhamnose-alpha-1,4-D-glucuronate lyase from Fusarium oxysporum 12S, N247A N-glycan free form | | 分子名称: | L-rhamnose-alpha-1,4-D-glucuronate lyase, SODIUM ION | | 著者 | Kondo, T, Arakawa, T, Fushinobu, S, Sakamoto, T. | | 登録日 | 2021-05-11 | | 公開日 | 2021-08-04 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural and functional analysis of gum arabic l-rhamnose-alpha-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family.
J.Biol.Chem., 297, 2021
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6HIG
 | | hPD-1/NBO1a Fab complex | | 分子名称: | Heavy Chain, Light Chain, Programmed cell death protein 1 | | 著者 | Loredo-Varela, J.L, Fenwick, C, Pantaleo, G, Weissenhorn, W. | | 登録日 | 2018-08-29 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Tumor suppression of novel anti-PD-1 antibodies mediated through CD28 costimulatory pathway.
J.Exp.Med., 216, 2019
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6FO7
 | | Vitamin D nuclear receptor complex 3 | | 分子名称: | (1~{R},3~{S},5~{Z})-4-methylidene-5-[(~{E})-3-[3-(6-methyl-6-oxidanyl-heptyl)phenyl]hept-2-enylidene]cyclohexane-1,3-diol, Nuclear receptor coactivator 1, Vitamin D3 receptor A | | 著者 | Rochel, N. | | 登録日 | 2018-02-06 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists.
J. Med. Chem., 61, 2018
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3ZJ5
 | | NEUROSPORA CRASSA CATALASE-3 EXPRESSED IN E. COLI, ORTHORHOMBIC FORM. | | 分子名称: | 1,2-ETHANEDIOL, 2-(2-ETHOXYETHOXY)ETHANOL, CATALASE-3, ... | | 著者 | Zarate-Romero, A, Rudino-Pinera, E. | | 登録日 | 2013-01-17 | | 公開日 | 2013-07-10 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Conformational Stability and Crystal Packing: Polymorphism in Neurospora Crassa Cat-3
Acta Crystallogr.,Sect.F, 69, 2013
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3L4S
 | | Crystal structure of C151G mutant of Glyceraldehyde 3-phosphate dehydrogenase 1 (GAPDH1) from methicillin resistant Staphylococcus aureus MRSA252 complexed with NAD and G3P | | 分子名称: | 3-PHOSPHOGLYCERIC ACID, Glyceraldehyde-3-phosphate dehydrogenase 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Mukherjee, S, Dutta, D, Saha, B, Das, A.K. | | 登録日 | 2009-12-21 | | 公開日 | 2010-08-18 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of glyceraldehyde-3-phosphate dehydrogenase 1 from methicillin-resistant Staphylococcus aureus MRSA252 provides novel insights into substrate binding and catalytic mechanism.
J.Mol.Biol., 401, 2010
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5IN2
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5Y0Z
 | | Human SIRT2 in complex with a specific inhibitor, NPD11033 | | 分子名称: | (1~{R},9~{S})-11-[(2~{R})-3-[2,4-bis(2-methylbutan-2-yl)phenoxy]-2-oxidanyl-propyl]-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, NAD-dependent protein deacetylase sirtuin-2, ZINC ION | | 著者 | Kudo, N, Ito, A, Yoshida, M. | | 登録日 | 2017-07-19 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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6JKE
 | | Discovery and the crystal structure of NS5 in complex with the N-terminal bromodomain of BRD2. | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 7-chloranyl-2-[(3-chlorophenyl)amino]pyrano[3,4-e][1,3]oxazine-4,5-dione, Bromodomain-containing protein 2, ... | | 著者 | Padmanabhan, B, Mathur, S, Deshmukh, P. | | 登録日 | 2019-02-28 | | 公開日 | 2020-07-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Novel pyrano 1,3 oxazine based ligand inhibits the epigenetic reader hBRD2 in glioblastoma.
Biochem.J., 477, 2020
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7DBN
 | | HIV-1 reverse transcriptase mutant Q151M/Y115F/F116Y/M184V/F160M:DNA:dCTP ternary complex | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA/RNA (38-MER), GLYCEROL, ... | | 著者 | Yasutake, Y, Hattori, S.I, Tamura, N, Maeda, K. | | 登録日 | 2020-10-21 | | 公開日 | 2021-08-04 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Biochemical and Structural Properties of Entecavir-Resistant Hepatitis B Virus Polymerase with L180M/M204V Mutations.
J.Virol., 95, 2021
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6AAR
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6MDY
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1LQP
 | | CRYSTAL STRUCTURE OF THE FOSFOMYCIN RESISTANCE PROTEIN (FOSA) CONTAINING BOUND SUBSTRATE | | 分子名称: | FOSFOMYCIN, MANGANESE (II) ION, POTASSIUM ION, ... | | 著者 | Rife, C.L, Pharris, R.E, Newcomer, M.E, Armstrong, R.N. | | 登録日 | 2002-05-11 | | 公開日 | 2002-09-11 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | | 主引用文献 | Crystal structure of a genomically encoded fosfomycin resistance protein (FosA) at 1.19 A resolution by MAD
phasing off the L-III edge of Tl(+)
J.Am.Chem.Soc., 124, 2002
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1PHA
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4BKR
 | | Enoyl-ACP reductase from Yersinia pestis (wildtype, removed Histag) with cofactor NADH | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Hirschbeck, M.W, Neckles, C, Tonge, P.J, Kisker, C. | | 登録日 | 2013-04-29 | | 公開日 | 2014-05-14 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia Pestis Fabv Enoyl-Acp Reductase.
Biochemistry, 55, 2016
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5X9D
 | | Crystal structure of homoserine dehydrogenase in complex with L-cysteine and NAD | | 分子名称: | (2R)-3-[[(4S)-3-aminocarbonyl-1-[(2R,3R,4S,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-3,4-bis(oxidanyl)oxolan-2-yl]-4H-pyridin-4-yl]sulfanyl]-2-azanyl-propanoic acid, Homoserine dehydrogenase, L(+)-TARTARIC ACID | | 著者 | Goto, M, Ogata, K, Kaneko, R, Yoshimune, K. | | 登録日 | 2017-03-06 | | 公開日 | 2018-05-02 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Inhibition of homoserine dehydrogenase by formation of a cysteine-NAD covalent complex
Sci Rep, 8, 2018
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7X2M
 | | Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD | | 分子名称: | 1-2C7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1 | | 著者 | Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X. | | 登録日 | 2022-02-25 | | 公開日 | 2022-12-14 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
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5JVZ
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3I4I
 | | Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome | | 分子名称: | 1,3-1,4-beta-glucanase, CALCIUM ION | | 著者 | Nakatani, Y, Nalder, T.D, Tannock, G.W, Cutfield, J.F, Jack, R.W, Carne, A. | | 登録日 | 2009-07-01 | | 公開日 | 2010-07-21 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Crystal structure of a prokaryotic beta-1,3-1,4-glucanase (lichenase) derived from a mouse hindgut metagenome
To be Published
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5GVA
 | | WD40 domain of human AND-1 | | 分子名称: | WD repeat and HMG-box DNA-binding protein 1 | | 著者 | Guan, C.C, Li, J. | | 登録日 | 2016-09-04 | | 公開日 | 2017-04-19 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.851 Å) | | 主引用文献 | The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome
J. Biol. Chem., 292, 2017
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6IJX
 | | Crystal Structure of AKR1C1 complexed with meclofenamic acid | | 分子名称: | 2-[(2,6-dichloro-3-methyl-phenyl)amino]benzoic acid, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zheng, X, Zhao, Y, Zhang, L, Zhang, H, Chen, Y, Hu, X. | | 登録日 | 2018-10-12 | | 公開日 | 2019-10-16 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Screening, synthesis, crystal structure, and molecular basis of 6-amino-4-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles as novel AKR1C3 inhibitors.
Bioorg.Med.Chem., 26, 2018
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