PDB: 8717 件ウェブページステータス検索Chemie searchBIRD

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5X6U	Crystal structure of human heteropentameric complex 分子名称: Ragulator complex protein LAMTOR1, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR3, ... 著者 Yonehara, R, Nada, S, Nakai, T, Nakai, M, Kitamura, A, Ogawa, A, Nakatsumi, H, Nakayama, K.I, Li, S, Standley, D.M, Yamashita, E, Nakagawa, A, Okada, M. 登録日 2017-02-23 公開日 2017-12-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structural basis for the assembly of the Ragulator-Rag GTPase complex. Nat Commun, 8, 2017
2OVR	Structure of the Skp1-Fbw7-CyclinEdegN complex 分子名称: F-box/WD repeat protein 7, S-phase kinase-associated protein 1A, SULFATE ION, ... 著者 Hao, B, Oehlmann, S, Sowa, M.E, Harper, J.W, Pavletich, N.P. 登録日 2007-02-14 公開日 2007-04-24 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases Mol.Cell, 26, 2007
1XO2	Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin 分子名称: 3,7,3',4'-TETRAHYDROXYFLAVONE, Cell division protein kinase 6, Cyclin 著者 Lu, H.S, Chang, D.J, Baratte, B, Meijer, L, Schulze-Gahmen, U. 登録日 2004-10-05 公開日 2005-03-01 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Crystal Structure of a Human Cyclin-Dependent Kinase 6 Complex with a Flavonol Inhibitor, Fisetin. J.Med.Chem., 48, 2005
1ZFS	Solution structure of S100A1 bound to calcium 分子名称: CALCIUM ION, S-100 protein, alpha chain 著者 Wright, N.T, Varney, K.M, Weber, D.J. 登録日 2005-04-20 公開日 2006-04-11 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 The three-dimensional solution structure of Ca(2+)-bound S100A1 as determined by NMR spectroscopy J.Mol.Biol., 353, 2006
1YZ5	The crystal structure of 14-3-3-sigma at 2.8 angstrom resolution 分子名称: 14-3-3 protein sigma 著者 Benzinger, A, Popowicz, G.M, Holak, T.A, Hermeking, H. 登録日 2005-02-28 公開日 2005-03-08 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization. Cell Res., 15, 2005
3NTP	Human Pin1 complexed with reduced amide inhibitor 分子名称: (2R)-2-(acetylamino)-3-[(2S)-2-{[2-(1H-indol-3-yl)ethyl]carbamoyl}pyrrolidin-1-yl]propyl dihydrogen phosphate, 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Zhang, Y. 登録日 2010-07-05 公開日 2012-01-04 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.762 Å) 主引用文献 A reduced-amide inhibitor of Pin1 binds in a conformation resembling a twisted-amide transition state. Biochemistry, 50, 2011
4I3Z	Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions 分子名称: ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Cyclin-A2, ... 著者 Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks, C.L, Young, M.A. 登録日 2012-11-27 公開日 2012-12-26 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase J.Am.Chem.Soc., 134, 2012
3OOB	Structural and functional insights of directly targeting Pin1 by Epigallocatechin-3-gallate 分子名称: (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl 3,4,5-trihydroxybenzoate, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, ... 著者 Urusova, D.V, Shim, J.-H, Kim, D.-J, Jung, S.K, Zykova, T.A, Bode, A.M, Dong, Z. 登録日 2010-08-30 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Epigallocatechin-gallate suppresses tumorigenesis by directly targeting Pin1. Cancer Prev Res (Phila), 4, 2011
3P1S	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide and stabilizer fusicoccin A 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
4II5	Structure of PCDK2/CYCLINA bound to ADP and 1 MAGNESIUM ION 分子名称: ADENOSINE-5'-DIPHOSPHATE, Cyclin-A2, Cyclin-dependent kinase 2, ... 著者 Jacobsen, D.M, Bao, Z.-Q, O'Brien, P.J, Brooks III, C.L, Young, M.A. 登録日 2012-12-19 公開日 2013-01-23 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Price to be paid for two-metal catalysis: Magnesium ions that accelerate chemistry unavoidably limit product release from a PROTEIN KINASE J.Am.Chem.Soc., 134, 2012
3P1P	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 peptide 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
3P1Q	Crystal structure of human 14-3-3 sigma C38N/N166H in complex with TASK-3 Peptide and stabilizer fusicoccin A 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
4IEA	14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide 分子名称: 14-3-3 protein sigma, RAF proto-oncogene serine/threonine-protein kinase 著者 Molzan, M, Ottmann, C. 登録日 2012-12-13 公開日 2013-09-25 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Stabilization of Physical RAF/14-3-3 Interaction by Cotylenin A as Treatment Strategy for RAS Mutant Cancers. Acs Chem.Biol., 8, 2013
4IWQ	Crystal structure and mechanism of activation of TBK1 分子名称: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 著者 Panne, D, Larabi, A. 登録日 2013-01-24 公開日 2013-03-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
3P1O	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator Fusicoccin A 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CALCIUM ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
4IWO	Crystal structure and mechanism of activation of TBK1 分子名称: N-{3-[(5-cyclopropyl-2-{[3-(2-oxopyrrolidin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 著者 Panne, D, Larabi, A. 登録日 2013-01-24 公開日 2013-03-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.61 Å) 主引用文献 Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep, 3, 2013
3P1N	Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide 分子名称: 14-3-3 protein sigma, 6-mer peptide from Potassium channel subfamily K member 9, CHLORIDE ION, ... 著者 Anders, C, Higuchi, Y, Schumacher, B, Thiel, P, Kato, N, Ottmann, C. 登録日 2010-09-30 公開日 2011-10-12 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A semisynthetic fusicoccane stabilizes a protein-protein interaction and enhances the expression of K+ channels at the cell surface Chem. Biol., 20, 2013
1NOU	Native human lysosomal beta-hexosaminidase isoform B 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, SULFATE ION, ... 著者 Mark, B.L, Mahuran, D.J, Cherney, M.M, Zhao, D, Knapp, S, James, M.N.G. 登録日 2003-01-16 公開日 2003-04-08 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of Human beta-hexosaminidase B: Understanding the molecular basis of Sandhoff and Tay-Sachs disease J.Mol.Biol., 327, 2003
4J1R	Crystal Structure of GSK3b in complex with inhibitor 15R 分子名称: (2R)-2-(1H-indol-3-ylmethyl)-1,4-dihydropyrido[2,3-b]pyrazin-3(2H)-one, Glycogen synthase kinase-3 beta, PHOSPHATE ION, ... 著者 Zhan, C, Wang, Y, Wach, J, Sheehan, P, Zhong, C, Harris, R, Patskovsky, Y, Bishop, J, Haggarty, S, Ramek, A, Berry, K, O'Herin, C, Koehler, A.N, Hung, A.W, Young, D.W, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) 登録日 2013-02-01 公開日 2013-03-20 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.702 Å) 主引用文献 Fragment-based approach using diversity-oriented synthesis yields a GSK3b inhibitor To be Published
4JD2	Crystal structure of Bos taurus Arp2/3 complex binding with Mus musculus GMF 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Actin-related protein 2, Actin-related protein 2/3 complex subunit 1B, ... 著者 Nolen, B.J, Luan, Q. 登録日 2013-02-22 公開日 2013-07-17 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.08 Å) 主引用文献 Structural basis for regulation of Arp2/3 complex by GMF. Nat.Struct.Mol.Biol., 20, 2013
3Q35	Structure of the Rtt109-AcCoA/Vps75 complex and implications for chaperone-mediated histone acetylation 分子名称: 1,2-ETHANEDIOL, ACETYL COENZYME *A, Histone acetyltransferase, ... 著者 Tang, Y, Yuan, H, Meeth, K, Marmorstein, R. 登録日 2010-12-21 公開日 2011-02-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (3.3 Å) 主引用文献 Structure of the Rtt109-AcCoA/Vps75 Complex and Implications for Chaperone-Mediated Histone Acetylation. Structure, 19, 2011
4JNM	Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties 分子名称: 1,2-ETHANEDIOL, 1-[(6-aminopyridin-3-yl)methyl]-3-[4-(phenylsulfonyl)phenyl]urea, Nicotinamide phosphoribosyltransferase, ... 著者 Gunzner-Toste, J, Zhao, G, Bauer, P, Baumeister, T, Buckmelter, A.J, Caligiuri, M, Clodfelter, K.H, Fu, B, Han, B, Ho, Y, Kley, N, Liederer, B, Lin, J, Mukadam, S, O'Brien, T, Reynolds, D.J, Sharma, G, Skelton, N, Smith, C.C, Oh, A, Wang, W, Wang, Z, Xiao, Y, Yuen, P, Zak, M, Zhang, L, Zheng, X, Bair, K.W, Dragovich, P.S. 登録日 2013-03-15 公開日 2013-05-29 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties. Bioorg.Med.Chem.Lett., 23, 2013
3Q3B	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel Glycogen Synthase Kinase-3 Inhibitors 分子名称: 4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(5H)-one, Glycogen synthase kinase-3 beta 著者 Pandit, J. 登録日 2010-12-21 公開日 2011-06-15 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 6-amino-4-(pyrimidin-4-yl)pyridones: novel glycogen synthase kinase-3β inhibitors Bioorg.Med.Chem.Lett., 21, 2011
4IM2	Structure of Tank-Binding Kinase 1 分子名称: CHLORIDE ION, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1 著者 Tu, D, Eck, M.J. 登録日 2013-01-01 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5001 Å) 主引用文献 Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013
4IM0	Structure of Tank-Binding Kinase 1 分子名称: N-{3-[(5-cyclopropyl-2-{[3-(morpholin-4-ylmethyl)phenyl]amino}pyrimidin-4-yl)amino]propyl}cyclobutanecarboxamide, Serine/threonine-protein kinase TBK1 著者 Tu, D, Eck, M.J. 登録日 2013-01-01 公開日 2013-03-06 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.4001 Å) 主引用文献 Structure and ubiquitination-dependent activation of TANK-binding kinase 1. Cell Rep, 3, 2013

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