PDB: 1384 件ウェブページステータス検索Chemie searchBIRD

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6XR4	Integrative in situ structure of Parkinsons disease-linked human LRRK2 分子名称: Leucine-rich repeat serine/threonine-protein kinase 2 著者 Villa, E, Lasker, K, Audagnotto, M. 登録日 2020-07-10 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (14 Å) 主引用文献 The In Situ Structure of Parkinson's Disease-Linked LRRK2. Cell, 182, 2020
1ZGN	Crystal Structure of the Glutathione Transferase Pi in Complex with Dinitrosyl-diglutathionyl Iron Complex 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FE (III) ION, GLUTATHIONE, ... 著者 Parker, L.J, Adams, J.J, Parker, M.W. 登録日 2005-04-21 公開日 2005-11-01 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Nitrosylation of human glutathione transferase P1-1 with dinitrosyl diglutathionyl iron complex in vitro and in vivo J.Biol.Chem., 280, 2005
8W41	Cryo-EM structure of Myosin VI in the autoinhibited state 分子名称: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin-1, ... 著者 Niu, F, Wei, Z. 登録日 2023-08-23 公開日 2024-02-21 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.54 Å) 主引用文献 Autoinhibition and activation of myosin VI revealed by its cryo-EM structure. Nat Commun, 15, 2024
2A2S	Crystal Structure of Human Glutathione Transferase in complex with S-nitrosoglutathione in the absence of reducing agent 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ... 著者 Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W. 登録日 2005-06-23 公開日 2006-06-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1 Protein Sci., 15, 2006
2A2R	Crystal Structure of Glutathione Transferase Pi in complex with S-nitrosoglutathione 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-5-[1-(CARBOXYLATOMETHYLCARBAMOYL)-2-NITROSOSULFANYL-ETHYL]AMINO-5-OXO-PENTANOATE, CALCIUM ION, ... 著者 Parker, L.J, Morton, C.J, Adams, J.J, Parker, M.W. 登録日 2005-06-23 公開日 2006-06-06 最終更新日 2023-10-25 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1 Protein Sci., 15, 2006
7NH4	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 3 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-[5-(hydroxymethyl)-3-phenyl-pyridin-2-yl]phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
7NH5	Co-Crystal Structure of Akt1 in Complex with Covalent-Allosteric Akt Inhibitor 6 分子名称: ACETATE ION, RAC-alpha serine/threonine-protein kinase, ~{N}-methyl-6-[4-[[4-[2-oxidanylidene-6-(propanoylamino)-3~{H}-benzimidazol-1-yl]piperidin-1-yl]methyl]phenyl]-5-phenyl-pyridine-3-carboxamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2021-02-10 公開日 2021-09-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Cellular model system to dissect the isoform-selectivity of Akt inhibitors. Nat Commun, 12, 2021
7Z3P	Crystal structure of the mouse leptin:LepR-CRH2 encounter complex to 1.95 A resolution. 分子名称: CALCIUM ION, DI(HYDROXYETHYL)ETHER, Leptin, ... 著者 Tsirigotaki, A, Verschueren, K, Savvides, S.N, Verstraete, K. 登録日 2022-03-02 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.943 Å) 主引用文献 Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
7Z3Q	Crystal structure of the human leptin:LepR-CRH2 encounter complex to 3.6 A resolution. 分子名称: Leptin, Leptin receptor 著者 Verstraete, K, Verschueren, K, Alexandra, T, Savvides, S.N. 登録日 2022-03-02 公開日 2023-03-22 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (3.617 Å) 主引用文献 Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nat.Struct.Mol.Biol., 30, 2023
8IB8	Human TRiC-PhLP2A-actin complex in the closed state 分子名称: ACTB protein (Fragment), Phosducin-like protein 3, T-complex protein 1 subunit alpha, ... 著者 Roh, S.H, Park, J, Kim, H, Lim, S. 登録日 2023-02-09 公開日 2023-12-20 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (4.42 Å) 主引用文献 A structural vista of phosducin-like PhLP2A-chaperonin TRiC cooperation during the ATP-driven folding cycle. Nat Commun, 15, 2024
8C5D	Glutathione transferase P1-1 from Mus musculus 分子名称: CALCIUM ION, CHLORIDE ION, GLYCEROL, ... 著者 Papageorgiou, A.C. 登録日 2023-01-06 公開日 2023-05-24 最終更新日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.28 Å) 主引用文献 Inhibition Analysis and High-Resolution Crystal Structure of Mus musculus Glutathione Transferase P1-1. Biomolecules, 13, 2023
3VN9	Rifined Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state 分子名称: 9-{5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-beta-L-ribofuranosyl}-9H-purin-6-amine, Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION 著者 Kinoshita, T, Matsuzaka, H, Nakai, R, Kirii, Y, Yokota, K, Tada, T, Matsumoto, T. 登録日 2012-01-05 公開日 2012-02-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state J.Biochem., 151, 2012
5X79	Human GST Pi conjugated with novel inhibitor, GS-ESF 分子名称: (2S)-2-azanyl-5-[[(2R)-3-(2-fluorosulfonylethylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Glutathione S-transferase P 著者 Tomoike, F, Shishido, Y, Fukui, K, Kimura, Y, Abe, H. 登録日 2017-02-24 公開日 2017-09-13 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1). Chem. Commun. (Camb.), 53, 2017
8A8M	Structure of the MAPK p38alpha in complex with its activating MAP2K MKK6 分子名称: Dual specificity mitogen-activated protein kinase kinase 6, MAGNESIUM ION, Mitogen-activated protein kinase 14, ... 著者 Bowler, M.W, Juyoux, P, Pellegrini, E. 登録日 2022-06-23 公開日 2022-07-13 最終更新日 2023-09-27 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Architecture of the MKK6-p38 alpha complex defines the basis of MAPK specificity and activation. Science, 381, 2023
9AVS	Human alpha-galactosidase A in complex with saposin B 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... 著者 Sawyer, T.K, Garman, S.C. 登録日 2024-03-04 公開日 2024-04-17 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (3.53 Å) 主引用文献 Human Saposin B Ligand Binding and Presentation to alpha-Galactosidase A. Biorxiv, 2024
8PR0	Cytoplasmic dynein-A heavy chain bound to dynactin-p150glued and IC-LC tower 分子名称: Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... 著者 Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. 登録日 2023-07-12 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (9.4 Å) 主引用文献 Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
8PR1	Cytoplasmic dynein-B heavy chain bound to IC-LC tower 分子名称: Cytoplasmic dynein 1 heavy chain 1, Cytoplasmic dynein 1 intermediate chain 2, Cytoplasmic dynein 1 light intermediate chain 2, ... 著者 Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. 登録日 2023-07-12 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (8.2 Å) 主引用文献 Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
8PTK	Composite structure of Dynein-Dynactin-JIP3-LIS1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ... 著者 Singh, K, Lau, C.K, Manigrasso, G, Gassmann, R, Carter, A.P. 登録日 2023-07-14 公開日 2024-03-27 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (10 Å) 主引用文献 Molecular mechanism of dynein-dynactin complex assembly by LIS1. Science, 383, 2024
1MVT	Analysis of Two Polymorphic Forms of a Pyrido[2,3-d]pyrimidine N9-C10 Reverse-Bridge Antifolate Binary Complex with Human Dihydrofolate Reductase 分子名称: 2,4-DIAMINO-6-[N-(3',4',5'-TRIMETHOXYBENZYL)-N-METHYLAMINO]PYRIDO[2,3-D]PYRIMIDINE, Dihydrofolate Reductase, SULFATE ION 著者 Cody, V, Galitsky, N, Luft, J.R, Pangborn, W.A, Gangjee, A. 登録日 2002-09-26 公開日 2003-04-01 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Analysis of two polymorphic forms of a pyrido[2,3-d]pyrimidine N9-C10 reversed-bridge antifolate binary complex with human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 59, 2003
8RGG	Structure of dynein-2 intermediate chain DYNC2I2 (WDR34) in complex with dynein-2 heavy chain DYNC2H1. 分子名称: Cytoplasmic dynein 2 intermediate chain 1, Cytoplasmic dynein 2 intermediate chain 2, Dynein light chain 1, ... 著者 Mukhopadhyay, A.G, Toropova, K, Daly, L, Wells, J, Vuolo, L, Mladenov, M, Seda, M, Jenkins, D, Stephens, D.J, Roberts, A.J. 登録日 2023-12-13 公開日 2024-03-20 最終更新日 2024-04-10 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structure and tethering mechanism of dynein-2 intermediate chains in intraflagellar transport. Embo J., 43, 2024
3ZKF	Structure of LC8 in complex with Nek9 phosphopeptide 分子名称: DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN 著者 Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D. 登録日 2013-01-22 公開日 2013-03-20 最終更新日 2013-05-15 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation J.Biol.Chem., 288, 2013
3ZKE	Structure of LC8 in complex with Nek9 peptide 分子名称: DYNEIN LIGHT CHAIN 1, CYTOPLASMIC, NEK9 PROTEIN 著者 Gallego, P, Velazquez-Campoy, A, Regue, L, Roig, J, Reverter, D. 登録日 2013-01-22 公開日 2013-03-20 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Structural Analysis of the Regulation of the Dynll/Lc8 Binding to Nek9 by Phosphorylation J.Biol.Chem., 288, 2013
6GZL	Complex between the dynein light chain DYNLL1/DLC8 and a peptide from the large myelin-associated glycoprotein L-MAG 分子名称: CHLORIDE ION, Dynein light chain 1, cytoplasmic, ... 著者 Myllykoski, M, Kursula, P. 登録日 2018-07-04 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.953 Å) 主引用文献 High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1. J. Neurochem., 147, 2018
6GZJ	Complex between the dynein light chain DYNLL1/DLC8 and the specific domain of large myelin-associated glycoprotein L-MAG 分子名称: CHLORIDE ION, Dynein light chain 1, cytoplasmic, ... 著者 Myllykoski, M, Kursula, P. 登録日 2018-07-04 公開日 2018-10-10 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.977 Å) 主引用文献 High-affinity heterotetramer formation between the large myelin-associated glycoprotein and the dynein light chain DYNLL1. J. Neurochem., 147, 2018
6S9W	Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 16a 分子名称: RAC-alpha serine/threonine-protein kinase, ~{N}-[3-[1-[[4-(5-methyl-6-oxidanylidene-3-phenyl-1~{H}-pyrazin-2-yl)phenyl]methyl]piperidin-4-yl]-2-oxidanylidene-1~{H}-benzimidazol-5-yl]propanamide 著者 Landel, I, Mueller, M.P, Rauh, D. 登録日 2019-07-15 公開日 2019-10-16 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity. Angew.Chem.Int.Ed.Engl., 58, 2019

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