5X79
Human GST Pi conjugated with novel inhibitor, GS-ESF
Summary for 5X79
Entry DOI | 10.2210/pdb5x79/pdb |
Descriptor | Glutathione S-transferase P, (2S)-2-azanyl-5-[[(2R)-3-(2-fluorosulfonylethylsulfanyl)-1-(2-hydroxy-2-oxoethylamino)-1-oxidanylidene-propan-2-yl]amino]-5-oxidanylidene-pentanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... (4 entities in total) |
Functional Keywords | gstp, covalent inhibitor, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : P09211 |
Total number of polymer chains | 2 |
Total formula weight | 47980.88 |
Authors | Tomoike, F.,Shishido, Y.,Fukui, K.,Kimura, Y.,Abe, H. (deposition date: 2017-02-24, release date: 2017-09-13, Last modification date: 2023-11-22) |
Primary citation | Shishido, Y.,Tomoike, F.,Kimura, Y.,Kuwata, K.,Yano, T.,Fukui, K.,Fujikawa, H.,Sekido, Y.,Murakami-Tonami, Y.,Kameda, T.,Shuto, S.,Abe, H. A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP1-1). Chem. Commun. (Camb.), 53:11138-11141, 2017 Cited by PubMed: 28848941DOI: 10.1039/c7cc05829b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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