PDB: 217477 件ウェブページステータス検索Chemie searchBIRD

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4UCD	N-terminal globular domain of the RSV Nucleoprotein in complex with the Nucleoprotein Phosphoprotein interaction inhibitor M81 分子名称: 1-[(2-chlorophenyl)methyl]pyrazole-3,5-dicarboxylic acid, NUCLEOPROTEIN, SULFATE ION 著者 Ouizougun-Oubari, M, Pereira, N, Tarus, B, Galloux, M, Tortorici, M.-A, Hoos, S, Baron, B, England, P, Bontems, F, Rey, F.A, Eleouet, J.-F, Sizun, C, Slama-Schwok, A, Duquerroy, S. 登録日 2014-12-03 公開日 2015-08-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.66 Å) 主引用文献 A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of the Human Respiratory Syncytial Virus. J.Virol., 89, 2015
4UC9	N-terminal globular domain of the RSV Nucleoprotein in complex with C- terminal dipeptide of the Phosphoprotein 分子名称: ASPARTIC ACID, NUCLEOPROTEIN, PHENYLALANINE, ... 著者 Ouizougun-Oubari, M, Pereira, N, Tarus, B, Galloux, M, Tortorici, M.-A, Hoos, S, Baron, B, England, P, Bontems, F, Rey, F.A, Eleouet, J.-F, Sizun, C, Slama-Schwok, A, Duquerroy, S. 登録日 2014-12-03 公開日 2015-08-19 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A Druggable Pocket at the Nucleocapsid/Phosphoprotein Interaction Site of the Human Respiratory Syncytial Virus. J.Virol., 89, 2015
2MEX	Structure of the tetrameric building block of the Salmonella Typhimurium PrgI Type three secretion system needle 分子名称: Protein PrgI 著者 Loquet, A, Habenstein, B, Chevelkov, V, Giller, K, Becker, S, Lange, A. 登録日 2013-10-01 公開日 2013-12-25 最終更新日 2024-05-01 実験手法 SOLID-STATE NMR 主引用文献 Atomic structure and handedness of the building block of a biological assembly. J.Am.Chem.Soc., 135, 2013
8SDX	ATAD2B bromodomain in complex with histone H4 acetylated at lysine 5 with Serine 1 mutation to Cysteine 分子名称: ATPase family AAA domain-containing protein 2B, SULFATE ION, histone H4S1CK5ac 著者 Phillips, M, Montgomery, C, Nix, J.C, Glass, K.C. 登録日 2023-04-07 公開日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.69 Å) 主引用文献 Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67, 2024
4UJ1	Protein Kinase A in complex with an Inhibitor 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(3S,4R)-4-(3-chlorophenyl)carbonylpyrrolidin-3-yl]-3H-quinazolin-4-one, CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, ... 著者 Alam, K.A, Engh, R.A. 登録日 2015-04-07 公開日 2016-04-13 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.768 Å) 主引用文献 Addressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of Pka and a Pkb Mimic. Chemistry, 22, 2016
6DMI	A multiconformer ligand model of 5T5 bound to BACE-1 分子名称: Beta-secretase 1, DIMETHYL SULFOXIDE, SODIUM ION, ... 著者 Hudson, B.M, van Zundert, G, Keedy, D.A, Fonseca, R, Heliou, A, Suresh, P, Borrelli, K, Day, T, Fraser, J.S, van den Bedem, H. 登録日 2018-06-05 公開日 2018-12-19 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 qFit-ligand Reveals Widespread Conformational Heterogeneity of Drug-Like Molecules in X-Ray Electron Density Maps. J. Med. Chem., 61, 2018
6DXZ	Rabbit N-acylethanolamine-hydrolyzing acid amidase (NAAA) in complex with non-covalent benzothiazole-piperazine inhibitor ARN19702, in presence of Triton X-100 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-[4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOXY]ETHOXY}ETHANOL, 4-(2,4,4-trimethylpentan-2-yl)phenol, ... 著者 Gorelik, A, Gebai, A, Illes, K, Piomelli, D, Nagar, B. 登録日 2018-07-01 公開日 2018-09-26 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular mechanism of activation of the immunoregulatory amidase NAAA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2M6N	3D solution structure of EMI1 (Early Mitotic Inhibitor 1) 分子名称: F-box only protein 5, ZINC ION 著者 Frye, J.J, Brown, N.G, Petzold, G, Watson, E.R, Royappa, G.R, Nourse, A, Jarvis, M, Kriwacki, R.W, Peters, J, Stark, H, Schulman, B.A. 登録日 2013-04-06 公開日 2013-05-29 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. Nat.Struct.Mol.Biol., 20, 2013
2MKP	N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6 分子名称: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles, ... 著者 Robertson, I.M, Pineda-Sanabria, S.E, Holmes, P.C, Sykes, B.D. 登録日 2014-02-11 公開日 2014-02-26 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Conformation of the critical pH sensitive region of troponin depends upon a single residue in troponin I. Arch.Biochem.Biophys., 552-553, 2014
8TFR	Apo Fab from C10-S66K antibody 分子名称: Heavy chain from Fab of C10_S66K antibody, Immunoglobulin G-binding protein G, Light chain from Fab of C10_S66K antibody 著者 Pholcharee, T, Wilson, I.A. 登録日 2023-07-11 公開日 2023-08-16 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 An Engineered Human-Antibody Fragment with Fentanyl Pan-Specificity That Reverses Carfentanil-Induced Respiratory Depression. Acs Chem Neurosci, 14, 2023
4W9N	Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan 分子名称: CHLORIDE ION, Enoyl-[acyl-carrier-protein] reductase, IMIDAZOLE, ... 著者 Sippel, K.H, Vyas, N.K, Sankaran, B, Quiocho, F.A. 登録日 2014-08-27 公開日 2014-10-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.84 Å) 主引用文献 Crystal structure of the human Fatty Acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. J.Biol.Chem., 289, 2014
2LZS	TatA oligomer 分子名称: Sec-independent protein translocase protein TatA 著者 Rodriguez, F.M, Berks, B.C, Schnell, J.R. 登録日 2012-10-08 公開日 2013-03-20 最終更新日 2013-04-24 実験手法 SOLUTION NMR 主引用文献 Structural model for the protein-translocating element of the twin-arginine transport system. Proc.Natl.Acad.Sci.USA, 110, 2013
2MC6	A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement 分子名称: DNA-directed RNA polymerase subunit beta', RNA polymerase inhibitor p7 著者 Liu, B, Shadrin, A, Sheppard, C, Xu, Y, Severinov, K, Matthews, S, Wigneshweraraj, S. 登録日 2013-08-15 公開日 2014-04-02 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement. Nucleic Acids Res., 42, 2014
2MDV	NMR structure of beta alpha alpha 38 分子名称: Designed protein 著者 Kier, B.L, Sheffler, W, Baker, D. 登録日 2013-09-18 公開日 2014-10-01 実験手法 SOLUTION NMR 主引用文献 Covalent Assembly of Homooligomeric Proteins Using Structure-templating Hubs To be Published
2MHU	THE THREE-DIMENSIONAL STRUCTURE OF HUMAN [113CD7] METALLOTHIONEIN-2 IN SOLUTION DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY 分子名称: CADMIUM ION, CD7 METALLOTHIONEIN-2 著者 Braun, W, Messerle, B.A, Schaeffer, A, Vasak, M, Kaegi, J.H.R, Wuthrich, K. 登録日 1990-05-14 公開日 1991-04-15 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. J.Mol.Biol., 214, 1990
4W82	Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase 分子名称: CHLORIDE ION, Fatty acid synthase, MAGNESIUM ION, ... 著者 Sippel, K.H, Vyas, N.K, Sankaran, B, Quiocho, F.A. 登録日 2014-08-22 公開日 2014-10-15 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structure of the human Fatty Acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. J.Biol.Chem., 289, 2014
2MLE	NMR structure of the C-domain of troponin C bound to the anchoring region of troponin I 分子名称: CALCIUM ION, Troponin C, slow skeletal and cardiac muscles 著者 Robertson, I.M, Baryshnikova, O.K, Mercier, P, Sykes, B.D. 登録日 2014-02-26 公開日 2014-03-12 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I. Biochemistry, 47, 2008
5KPS	Structure of RelA bound to ribosome in absence of A/R tRNA (Structure I) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Loveland, A.B, Bah, E, Madireddy, R, Zhang, Y, Brilot, A.F, Grigorieff, N, Korostelev, A.A. 登録日 2016-07-05 公開日 2016-09-28 最終更新日 2019-11-20 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Ribosome•RelA structures reveal the mechanism of stringent response activation. Elife, 5, 2016
6WD5	Cryo-EM of elongating ribosome with EF-Tu*GTP elucidates tRNA proofreading (Cognate Structure II-C1) 分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... 著者 Loveland, A.B, Demo, G, Korostelev, A.A. 登録日 2020-03-31 公開日 2020-07-08 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Cryo-EM of elongating ribosome with EF-Tu•GTP elucidates tRNA proofreading. Nature, 584, 2020
5LBP	Oceanobacillus iheyensis macrodomain mutant N30A 分子名称: MacroD-type macrodomain, PHOSPHATE ION 著者 Gil-Ortiz, F, Zapata-Perez, R, Martinez, A.B, Juanhuix, J, Sanchez-Ferrer, A. 登録日 2016-06-16 公開日 2017-05-03 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 Structural and functional analysis of Oceanobacillus iheyensis macrodomain reveals a network of waters involved in substrate binding and catalysis. Open Biol, 7, 2017
2AWE	Base-Tetrad Swapping Results in Dimerization of RNA Quadruplexes: Implications for Formation of I-Motif RNA Octaplex 分子名称: 5'-R(*UP*(BGM)P*GP*UP*GP*U)-3', POTASSIUM ION, STRONTIUM ION 著者 Pan, B, Shi, K, Sundaralingam, M. 登録日 2005-08-31 公開日 2006-02-07 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Base-tetrad swapping results in dimerization of RNA quadruplexes: implications for formation of the i-motif RNA octaplex. Proc.Natl.Acad.Sci.Usa, 103, 2006
9B8E	Structure of S-nitrosylated Legionella pneumophila Ceg10. 分子名称: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... 著者 Tomchick, D.R, Heisler, D.B, Alto, N.M. 登録日 2024-03-29 公開日 2024-04-10 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
2AXV	Structure of PrgX Y153C mutant 分子名称: PrgX 著者 Shi, K, Brown, C.K, Gu, Z.Y, Kozlowicz, B.K, Dunny, G.M, Ohlendorf, D.H, Earhart, C.A. 登録日 2005-09-06 公開日 2005-12-06 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 Structure of peptide sex pheromone receptor PrgX and PrgX/pheromone complexes and regulation of conjugation in Enterococcus faecalis. Proc.Natl.Acad.Sci.Usa, 102, 2005
2AZ2	Flock House virus B2-dsRNA Complex (P4122) 分子名称: 5'-R(*GP*CP*AP*(5BU)P*GP*GP*AP*CP*GP*CP*GP*(5BU)P*CP*CP*AP*(5BU)P*GP*C)-3', B2 protein 著者 Chao, J.A, Lee, J.H, Chapados, B.R, Debler, E.W, Schneemann, A, Williamson, J.R. 登録日 2005-09-09 公開日 2005-10-11 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Dual modes of RNA-silencing suppression by Flock House virus protein B2. Nat.Struct.Mol.Biol., 12, 2005
2AZB	HIV-1 Protease NL4-3 3X mutant in complex with inhibitor, TL-3 分子名称: PROTEASE RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate 著者 Heaslet, H, Kutilek, V, Morris, G.M, Lin, Y.-C, Elder, J.H, Torbett, B.E, Stout, C.D. 登録日 2005-09-09 公開日 2006-02-28 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3 J.Mol.Biol., 356, 2006

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