2MKP

N domain of cardiac troponin C bound to the switch fragment of fast skeletal troponin I at pH 6

Summary for 2MKP

• Entry DOI: 10.2210/pdb2mkp/pdb
• NMR Information: BMRB: 19789
• Descriptor: Troponin C, slow skeletal and cardiac muscles, Troponin I, fast skeletal muscle, CALCIUM ION (3 entities in total)
• Functional Keywords: troponin c, troponin i, ef-hand, calcium binding, ischemia, metal binding protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 11972.67

Authors

Robertson, I.M.,Pineda-Sanabria, S.E.,Holmes, P.C.,Sykes, B.D. (deposition date: 2014-02-11, release date: 2014-02-26, Last modification date: 2014-06-18)

• Primary citation: Robertson, I.M.,Pineda-Sanabria, S.E.,Holmes, P.C.,Sykes, B.D.; Conformation of the critical pH sensitive region of troponin depends upon a single residue in troponin I.; Arch.Biochem.Biophys., 552-553:40-49, 2014; PubMed: 24333682; DOI: 10.1016/j.abb.2013.12.003

Experimental method

SOLUTION NMR