4W9N
Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan
Summary for 4W9N
Entry DOI | 10.2210/pdb4w9n/pdb |
Related | 4W82 |
Descriptor | Enoyl-[acyl-carrier-protein] reductase, IMIDAZOLE, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | fatty acid synthase, fatty acid metabolism, nadph-dependent, enoyl reductase, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Cellular location | Cytoplasm : P49327 P49327 |
Total number of polymer chains | 4 |
Total formula weight | 148294.73 |
Authors | Sippel, K.H.,Vyas, N.K.,Sankaran, B.,Quiocho, F.A. (deposition date: 2014-08-27, release date: 2014-10-15, Last modification date: 2023-09-27) |
Primary citation | Sippel, K.H.,Vyas, N.K.,Zhang, W.,Sankaran, B.,Quiocho, F.A. Crystal structure of the human Fatty Acid synthase enoyl-acyl carrier protein-reductase domain complexed with triclosan reveals allosteric protein-protein interface inhibition. J.Biol.Chem., 289:33287-33295, 2014 Cited by PubMed: 25301948DOI: 10.1074/jbc.M114.608547 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.84 Å) |
Structure validation
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