4W9N

Enoyl-acyl carrier protein-reductase domain from human fatty acid synthase complexed with triclosan

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
B	0016491	molecular_function	oxidoreductase activity
C	0016491	molecular_function	oxidoreductase activity
D	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue IMD A 1901

Chain	Residue
A	MET1601
A	VAL1617
A	PRO1618
A	PHE1800
A	HOH2030

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 1902

Chain	Residue
A	PHE1712
A	PRO1713
A	GLN1714

---

site_id	AC3
Number of Residues	2
Details	binding site for residue CL A 1903

Chain	Residue
A	PHE1772
A	PHE1573

---

site_id	AC4
Number of Residues	5
Details	binding site for residue IMD B 1901

Chain	Residue
B	MET1601
B	VAL1617
B	PRO1618
B	PHE1800
B	HOH2020

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL B 1902

Chain	Residue
B	LEU1598

---

site_id	AC6
Number of Residues	3
Details	binding site for residue CL B 1903

Chain	Residue
B	PHE1712
B	PRO1713
B	GLN1714

---

site_id	AC7
Number of Residues	1
Details	binding site for residue NA B 1904

Chain	Residue
B	PHE1772

---

site_id	AC8
Number of Residues	7
Details	binding site for residue TCL B 1905

Chain	Residue
A	LEU1753
A	PHE1766
A	PHE1791
B	PHE1766
B	LEU1780
B	ILE1784
B	PHE1791

---

site_id	AC9
Number of Residues	6
Details	binding site for residue IMD C 1901

Chain	Residue
C	MET1601
C	VAL1617
C	PRO1618
C	ASP1797
C	PHE1800
C	HOH2048

---

site_id	AD1
Number of Residues	6
Details	binding site for residue NA C 1902

Chain	Residue
C	THR1697
C	VAL1699
C	PHE1720
C	ALA1721
C	ASN1722
C	SER1723

---

site_id	AD2
Number of Residues	1
Details	binding site for residue CL C 1903

Chain	Residue
C	PHE1772

---

site_id	AD3
Number of Residues	4
Details	binding site for residue IMD D 1901

Chain	Residue
D	LEU1616
D	VAL1617
D	PHE1800
D	HOH2053

---

site_id	AD4
Number of Residues	3
Details	binding site for residue NA D 1902

Chain	Residue
D	PHE1712
D	PRO1713
D	GLN1714

---

site_id	AD5
Number of Residues	4
Details	binding site for residue NA D 1903

Chain	Residue
B	HOH2041
D	TRP1811
D	HOH2016
D	HOH2050

---

site_id	AD6
Number of Residues	7
Details	binding site for residue TCL D 1904

Chain	Residue
C	PHE1766
C	LEU1780
C	ILE1784
C	PHE1791
D	PHE1766
D	ILE1784
D	PHE1791

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19096","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---