8SDX

ATAD2B bromodomain in complex with histone H4 acetylated at lysine 5 with Serine 1 mutation to Cysteine

Summary for 8SDX

Entry DOI	10.2210/pdb8sdx/pdb
Descriptor	ATPase family AAA domain-containing protein 2B, histone H4S1CK5ac, SULFATE ION, ... (4 entities in total)
Functional Keywords	bromodomains, epigenetics, chromatin reader domain, protein binding, nuclear protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	34443.39
Authors	Phillips, M.,Montgomery, C.,Nix, J.C.,Glass, K.C. (deposition date: 2023-04-07, release date: 2024-06-05)
Primary citation	Phillips, M.,Malone, K.L.,Boyle, B.W.,Montgomery, C.,Kressy, I.A.,Joseph, F.M.,Bright, K.M.,Boyson, S.P.,Chang, S.,Nix, J.C.,Young, N.L.,Jeffers, V.,Frietze, S.,Glass, K.C. Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains. J.Med.Chem., 67:8186-8200, 2024 Cited by PubMed: 38733345 DOI: 10.1021/acs.jmedchem.4c00210 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.69 Å)

Structure validation