4JQE
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![BU of 4jqe by Molmil](/molmil-images/mine/4jqe) | Crystal structure of scCK2 alpha in complex with AMPPN | 分子名称: | Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Liu, H. | 登録日 | 2013-03-20 | 公開日 | 2014-03-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D, 70, 2014
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4JR7
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![BU of 4jr7 by Molmil](/molmil-images/mine/4jr7) | Crystal structure of scCK2 alpha in complex with GMPPNP | 分子名称: | Casein kinase II subunit alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Liu, H. | 登録日 | 2013-03-21 | 公開日 | 2014-03-05 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D, 70, 2014
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4MH8
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8V4Y
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![BU of 8v4y by Molmil](/molmil-images/mine/8v4y) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 1) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, Histone H2A type 1, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-11-29 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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8V6V
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![BU of 8v6v by Molmil](/molmil-images/mine/8v6v) | Cryo-EM structure of doubly-bound SNF2h-nucleosome complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-03 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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6Q21
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8V7L
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![BU of 8v7l by Molmil](/molmil-images/mine/8v7l) | Cryo-EM structure of singly-bound SNF2h-nucleosome complex with SNF2h at inactive SHL2 (conformation 2) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Histone H2A type 1, Histone H2B, ... | 著者 | Chio, U.S, Palovcak, E, Armache, J.P, Narlikar, G.J, Cheng, Y. | 登録日 | 2023-12-04 | 公開日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Functionalized graphene-oxide grids enable high-resolution cryo-EM structures of the SNF2h-nucleosome complex without crosslinking. Nat Commun, 15, 2024
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6TE1
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![BU of 6te1 by Molmil](/molmil-images/mine/6te1) | Structure of the KDM1A/CoREST complex with the inhibitor 2-[3-{4-chloro-3-[(4-chlorophenyl)ethynyl]phenyl}-1-(3-morpholin-4-ylpropyl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-2-oxoethanol | 分子名称: | 5-[4-cyclobutyl-1-[2-(4-piperidin-4-yloxyphenoxy)ethyl]imidazol-2-yl]-4-methyl-thieno[3,2-b]pyrrole, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Pasqualato, S, Cecatiello, V. | 登録日 | 2019-11-11 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | 主引用文献 | Discovery of Reversible Inhibitors of KDM1A Efficacious in Acute Myeloid Leukemia Models. Acs Med.Chem.Lett., 11, 2020
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5N4W
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![BU of 5n4w by Molmil](/molmil-images/mine/5n4w) | Crystal structure of the Cul2-Rbx1-EloBC-VHL ubiquitin ligase complex | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | 著者 | Cardote, T.A.F, Gadd, M.S, Ciulli, A. | 登録日 | 2017-02-11 | 公開日 | 2017-06-07 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex. Structure, 25, 2017
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4MWH
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![BU of 4mwh by Molmil](/molmil-images/mine/4mwh) | Crystal structure of scCK2 alpha in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, MAGNESIUM ION, ... | 著者 | Liu, H. | 登録日 | 2013-09-24 | 公開日 | 2013-11-20 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway. Acta Crystallogr.,Sect.D, 70, 2014
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6LUF
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6PWV
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![BU of 6pwv by Molmil](/molmil-images/mine/6pwv) | Cryo-EM structure of MLL1 core complex bound to the nucleosome | 分子名称: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | 著者 | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | 登録日 | 2019-07-23 | 公開日 | 2019-12-18 | 最終更新日 | 2023-08-16 | 実験手法 | ELECTRON MICROSCOPY (6.2 Å) | 主引用文献 | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
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6LUA
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![BU of 6lua by Molmil](/molmil-images/mine/6lua) | |
6O9E
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![BU of 6o9e by Molmil](/molmil-images/mine/6o9e) | Structure of HIV-1 Reverse Transcriptase in complex with DNA and INDOPY-1 | 分子名称: | 5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido[3,2-b]indole-3-carbonitrile, AMMONIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Ruiz, F.X, Hoang, A, Das, K, Arnold, E. | 登録日 | 2019-03-13 | 公開日 | 2019-10-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. J.Med.Chem., 62, 2019
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8OF4
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![BU of 8of4 by Molmil](/molmil-images/mine/8of4) | Nucleosome Bound human SIRT6 (Composite) | 分子名称: | DNA (145-MER), Histone H2A type 1, Histone H2B, ... | 著者 | Smirnova, E, Bignon, E, Schultz, P, Papai, G, Ben-Shem, A. | 登録日 | 2023-03-13 | 公開日 | 2023-08-09 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Binding to nucleosome poises human SIRT6 for histone H3 deacetylation. Elife, 12, 2024
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4XFV
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![BU of 4xfv by Molmil](/molmil-images/mine/4xfv) | Crystal Structure of Elp2 | 分子名称: | Elongator complex protein 2 | 著者 | Lin, Z, Dong, C, Long, J, Shen, Y. | 登録日 | 2014-12-29 | 公開日 | 2015-05-20 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The elp2 subunit is essential for elongator complex assembly and functional regulation Structure, 23, 2015
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7YEA
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![BU of 7yea by Molmil](/molmil-images/mine/7yea) | Human O-GlcNAc transferase Dimer | 分子名称: | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | 著者 | Gao, H, Lu, P, Liu, Y. | 登録日 | 2022-07-05 | 公開日 | 2023-07-12 | 最終更新日 | 2024-01-24 | 実験手法 | ELECTRON MICROSCOPY (3.82 Å) | 主引用文献 | Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex. Nat Commun, 14, 2023
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5CCM
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![BU of 5ccm by Molmil](/molmil-images/mine/5ccm) | Crystal structure of SMYD3 with SAM and EPZ030456 | 分子名称: | 6-chloranyl-2-oxidanylidene-N-[(1S,5R)-8-[4-[(phenylmethyl)amino]piperidin-1-yl]sulfonyl-8-azabicyclo[3.2.1]octan-3-yl]-1,3-dihydroindole-5-carboxamide, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYLMETHIONINE, ... | 著者 | Boriack-Sjodin, P.A. | 登録日 | 2015-07-02 | 公開日 | 2015-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. Acs Med.Chem.Lett., 7, 2016
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5CCL
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![BU of 5ccl by Molmil](/molmil-images/mine/5ccl) | Crystal structure of SMYD3 with SAM and oxindole compound | 分子名称: | 1,2-ETHANEDIOL, 2-oxidanylidene-N-piperidin-4-yl-1,3-dihydroindole-5-carboxamide, Histone-lysine N-methyltransferase SMYD3, ... | 著者 | Boriack-Sjodin, P.A. | 登録日 | 2015-07-02 | 公開日 | 2015-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. Acs Med.Chem.Lett., 7, 2016
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8SZK
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7K1B
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7K11
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7K0Y
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![BU of 7k0y by Molmil](/molmil-images/mine/7k0y) | Cryo-EM structure of activated-form DNA-PK (complex VI) | 分子名称: | DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), DNA-dependent protein kinase catalytic subunit, ... | 著者 | Chen, X, Gellert, M, Yang, W. | 登録日 | 2020-09-06 | 公開日 | 2021-01-06 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structure of an activated DNA-PK and its implications for NHEJ. Mol.Cell, 81, 2021
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7K10
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5ZBA
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![BU of 5zba by Molmil](/molmil-images/mine/5zba) | Crystal structure of Rtt109-Asf1-H3-H4-CoA complex | 分子名称: | COENZYME A, DNA damage response protein Rtt109, putative, ... | 著者 | Zhang, L, Serra-Cardona, A, Zhou, H, Wang, M, Yang, N, Zhang, Z, Xu, R.M. | 登録日 | 2018-02-10 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Multisite Substrate Recognition in Asf1-Dependent Acetylation of Histone H3 K56 by Rtt109. Cell, 174, 2018
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