4WNK
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![BU of 4wnk by Molmil](/molmil-images/mine/4wnk) | Crystal Structure of Bovine G Protein Coupled-Receptor Kinase 5 in Complex with CCG215022 | 分子名称: | (4S)-4-{4-fluoro-3-[(pyridin-2-ylmethyl)carbamoyl]phenyl}-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide, G protein-coupled receptor kinase 5, SULFATE ION | 著者 | Homan, K.T, Tesmer, J.J.G. | 登録日 | 2014-10-13 | 公開日 | 2015-06-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J.Biol.Chem., 290, 2015
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5LAA
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7P9Q
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![BU of 7p9q by Molmil](/molmil-images/mine/7p9q) | Crystal structure of Indole 3-Carboxylic acid decarboxylase from Arthrobacter nicotianae FI1612 in complex with co-factor prFMN. | 分子名称: | 1-deoxy-5-O-phosphono-1-(3,3,4,5-tetramethyl-9,11-dioxo-2,3,8,9,10,11-hexahydro-7H-quinolino[1,8-fg]pteridin-12-ium-7-y l)-D-ribitol, AnInD, MANGANESE (II) ION, ... | 著者 | Gahloth, D, Leys, D. | 登録日 | 2021-07-27 | 公開日 | 2022-03-02 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structural and biochemical characterization of the prenylated flavin mononucleotide-dependent indole-3-carboxylic acid decarboxylase. J.Biol.Chem., 298, 2022
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4WQA
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![BU of 4wqa by Molmil](/molmil-images/mine/4wqa) | Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum - tetrathionate co-crystallization | 分子名称: | 1,2-ETHANEDIOL, HEME C, IODIDE ION, ... | 著者 | Brito, J.A, Denkmann, K, Pereira, I.A.C, Dahl, C, Archer, M. | 登録日 | 2014-10-21 | 公開日 | 2015-02-18 | 最終更新日 | 2015-04-15 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION. J.Biol.Chem., 290, 2015
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4WQ8
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![BU of 4wq8 by Molmil](/molmil-images/mine/4wq8) | Thiosulfate dehydrogenase (TsdA) from Allochromatium vinosum - tetrathionate soak | 分子名称: | HEME C, IODIDE ION, SULFATE ION, ... | 著者 | Brito, J.A, Denkmann, K, Pereira, I.A.C, Dahl, C, Archer, M. | 登録日 | 2014-10-21 | 公開日 | 2015-02-18 | 最終更新日 | 2018-03-07 | 実験手法 | X-RAY DIFFRACTION (1.3989 Å) | 主引用文献 | Thiosulfate Dehydrogenase (TsdA) from Allochromatium vinosum: STRUCTURAL AND FUNCTIONAL INSIGHTS INTO THIOSULFATE OXIDATION. J.Biol.Chem., 290, 2015
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4MDZ
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![BU of 4mdz by Molmil](/molmil-images/mine/4mdz) | Crystal structure of a HD-GYP domain (a cyclic-di-GMP phosphodiesterase) containing a tri-nuclear metal centre | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), FE (III) ION, Metal dependent phosphohydrolase, ... | 著者 | Bellini, D, Walsh, M.A, Oxford Protein Production Facility (OPPF) | 登録日 | 2013-08-23 | 公開日 | 2014-02-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Crystal structure of an HD-GYP domain cyclic-di-GMP phosphodiesterase reveals an enzyme with a novel trinuclear catalytic iron centre. Mol.Microbiol., 91, 2014
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5EIE
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![BU of 5eie by Molmil](/molmil-images/mine/5eie) | mAChE-TZ2 complex | 分子名称: | 2,5,8,11,14,17,20,23-OCTAOXAPENTACOSAN-25-OL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Bourne, Y, Marchot, P. | 登録日 | 2015-10-29 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase. J.Am.Chem.Soc., 138, 2016
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5SD6
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7P0P
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![BU of 7p0p by Molmil](/molmil-images/mine/7p0p) | NAF-1 bound to M1 molecule | 分子名称: | 2-benzamido-4-[(2~{R})-1,2,3,4-tetrahydronaphthalen-2-yl]thiophene-3-carboxylic acid, CDGSH iron-sulfur domain-containing protein 2, FE2/S2 (INORGANIC) CLUSTER | 著者 | Livnah, O, Eisenberg-Domovich, Y, Marjault, H.B, Nechushtai, R. | 登録日 | 2021-06-30 | 公開日 | 2022-05-25 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters. Commun Biol, 5, 2022
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8K0D
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8EL0
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![BU of 8el0 by Molmil](/molmil-images/mine/8el0) | Structure of MBP-Mcl-1 in complex with a macrocyclic compound | 分子名称: | (7R,20P)-18-chloro-1-(4-fluorophenyl)-10-{[(2M)-2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}-19-methyl-15-[2-(4-methylpiperazin-1-yl)ethyl]-7,8,15,16-tetrahydro-14H-17,20-etheno-9,13-(metheno)-6-oxa-2-thia-3,5,15-triazacyclooctadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Judge, R.A, Judd, A.S, Souers, A.J. | 登録日 | 2022-09-22 | 公開日 | 2023-10-04 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.917 Å) | 主引用文献 | Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
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8K0C
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4M2S
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![BU of 4m2s by Molmil](/molmil-images/mine/4m2s) | Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR | 分子名称: | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1A | 著者 | Li, J, Jaimes, K.F, Aller, S.G. | 登録日 | 2013-08-05 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Refined structures of mouse P-glycoprotein. Protein Sci., 23, 2014
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2ROY
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![BU of 2roy by Molmil](/molmil-images/mine/2roy) | TRANSTHYRETIN (ALSO CALLED PREALBUMIN) COMPLEX WITH 3',5'-DINITRO-N-ACETYL-L-THYRONINE | 分子名称: | 3',5'-DINITRO-N-ACETYL-L-THYRONINE, TRANSTHYRETIN | 著者 | Wojtczak, A, Cody, V, Luft, J.R, Pangborn, W. | 登録日 | 1996-10-23 | 公開日 | 1997-04-21 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of human transthyretin complexed with thyroxine at 2.0 A resolution and 3',5'-dinitro-N-acetyl-L-thyronine at 2.2 A resolution. Acta Crystallogr.,Sect.D, 52, 1996
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8EL1
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![BU of 8el1 by Molmil](/molmil-images/mine/8el1) | Structure of MBP-Mcl-1 in complex with ABBV-467 | 分子名称: | (7R,16R)-19,23-dichloro-10-{[2-(4-{[(2R)-1,4-dioxan-2-yl]methoxy}phenyl)pyrimidin-4-yl]methoxy}-1-(4-fluorophenyl)-20,22-dimethyl-16-[(4-methylpiperazin-1-yl)methyl]-7,8,15,16-tetrahydro-18,21-etheno-13,9-(metheno)-6,14,17-trioxa-2-thia-3,5-diazacyclononadeca[1,2,3-cd]indene-7-carboxylic acid, Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Judge, R.A, Judd, A.S, Souers, A.J. | 登録日 | 2022-09-22 | 公開日 | 2023-10-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.406 Å) | 主引用文献 | Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond), 3, 2023
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8CGJ
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![BU of 8cgj by Molmil](/molmil-images/mine/8cgj) | Streptomycin bound to the 30S body | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S16, ... | 著者 | Paternoga, H, Crowe-McAuliffe, C, Beckert, B, Wilson, D.N. | 登録日 | 2023-02-05 | 公開日 | 2023-07-26 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (1.79 Å) | 主引用文献 | Structural conservation of antibiotic interaction with ribosomes. Nat.Struct.Mol.Biol., 30, 2023
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8F1Z
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![BU of 8f1z by Molmil](/molmil-images/mine/8f1z) | EGFR kinase in complex with Bayer #33 | 分子名称: | (2P)-3-(3-chloro-2-methoxyanilino)-2-[3-(2-methoxy-2-methylpropoxy)pyridin-4-yl]-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one, CITRIC ACID, Epidermal growth factor receptor | 著者 | Beyett, T.S, Eck, M.J. | 登録日 | 2022-11-06 | 公開日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | EGFR kinase in complex with Bayer #33 To be published
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4WXH
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![BU of 4wxh by Molmil](/molmil-images/mine/4wxh) | Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | 著者 | Metsa-Ketela, M, Niiranen, L. | 登録日 | 2014-11-13 | 公開日 | 2015-07-29 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis. Proc.Natl.Acad.Sci.USA, 112, 2015
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6X7Q
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![BU of 6x7q by Molmil](/molmil-images/mine/6x7q) | Chloramphenicol acetyltransferase type III in complex with chloramphenicol and acetyl-oxa(dethia)-CoA | 分子名称: | CHLORAMPHENICOL, Chloramphenicol acetyltransferase 3, DI(HYDROXYETHYL)ETHER, ... | 著者 | Benjamin, A.B, Stunkard, L.M, Ling, J, Nice, J.N, Lohman, J.R. | 登録日 | 2020-05-30 | 公開日 | 2021-06-02 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Structures of chloramphenicol acetyltransferase III and Escherichia coli beta-keto-acylsynthase III co-crystallized with partially hydrolysed acetyl-oxa(de-thia)CoA Acta Crystallogr.,Sect.F, 2023
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7OWB
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![BU of 7owb by Molmil](/molmil-images/mine/7owb) | Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | 著者 | Dinis, P, MetsaKetela, M. | 登録日 | 2021-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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8ESS
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![BU of 8ess by Molmil](/molmil-images/mine/8ess) | Myoglobin variant Mb-cIII complex | 分子名称: | Myoglobin, SULFATE ION, [2,18-bis(2-carboxyethyl)-7,12-diethenyl-3,8,13,17-tetramethyl-21-(2-oxo-3-phenylpropyl)porphyrin-21-iumato(2-)-kappa~3~N~22~,N~23~,N~24~]iron(2+) | 著者 | Bacik, J.P, Fasan, R, Ando, N. | 登録日 | 2022-10-14 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone. Nat Commun, 14, 2023
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6EA8
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![BU of 6ea8 by Molmil](/molmil-images/mine/6ea8) | Structure of VACV poxin in pre-reactive state with nonhydrolyzable 2'3' cGAMP | 分子名称: | (2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-disulfanyloctahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, O-[(1R,2R,3R)-5-{[(S)-{[(2R,3R,4R,5R)-2-(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydro furan-3-yl]oxy}(sulfanyl)phosphoryl]oxy}-1-(6-amino-9H-purin-9-yl)-1,2-dihydroxypentan-3-yl] dihydrogen (R)-phosphorothioate, Protein B2 | 著者 | Eaglesham, J.B, Kranzusch, P.J. | 登録日 | 2018-08-02 | 公開日 | 2019-02-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature, 566, 2019
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6U3G
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7OY1
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![BU of 7oy1 by Molmil](/molmil-images/mine/7oy1) | DnrK mutant RTCR | 分子名称: | Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate | 著者 | Dinis, P, MetsaKetela, M. | 登録日 | 2021-06-23 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2, 2023
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4HMZ
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![BU of 4hmz by Molmil](/molmil-images/mine/4hmz) | Crystal Structure of ChmJ, a 3'-monoepimerase from Streptomyces bikiniensis in complex with dTDP-quinovose | 分子名称: | 1,2-ETHANEDIOL, Putative 3-epimerase in D-allose pathway, [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl (2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl dihydrogen diphosphate | 著者 | Holden, H.M, Kubiak, R.L. | 登録日 | 2012-10-18 | 公開日 | 2012-11-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and Functional Studies on a 3'-Epimerase Involved in the Biosynthesis of dTDP-6-deoxy-d-allose. Biochemistry, 51, 2012
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