4M2S

Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR

Summary for 4M2S

• Entry DOI: 10.2210/pdb4m2s/pdb
• Related: 3G5U 3G60 3G61 4M1M 4M2T
• Descriptor: Multidrug resistance protein 1A, (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione (2 entities in total)
• Functional Keywords: atp-binding cassette transporter, multidrug efflux, adenosine triphosphate, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Mus musculus (mouse)
• Cellular location: Cell membrane; Multi-pass membrane protein: P21447
• Total number of polymer chains: 2
• Total formula weight: 284730.20

Authors

Li, J.,Jaimes, K.F.,Aller, S.G. (deposition date: 2013-08-05, release date: 2013-11-13, Last modification date: 2024-02-28)

• Primary citation: Li, J.,Jaimes, K.F.,Aller, S.G.; Refined structures of mouse P-glycoprotein.; Protein Sci., 23:34-46, 2014; PubMed: 24155053; DOI: 10.1002/pro.2387

Experimental method

X-RAY DIFFRACTION (4.4 Å)