4WXH

Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T

Summary for 4WXH

Entry DOI	10.2210/pdb4wxh/pdb
Related	1TW2 1TW3
Descriptor	Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, ... (6 entities in total)
Functional Keywords	methyltransferase, mono-oxygenase, sah binding, antibiotic binding, transferase
Biological source	Streptomyces peucetius
Total number of polymer chains	2
Total formula weight	82939.58
Authors	Metsa-Ketela, M.,Niiranen, L. (deposition date: 2014-11-13, release date: 2015-07-29, Last modification date: 2024-01-10)
Primary citation	Grocholski, T.,Dinis, P.,Niiranen, L.,Niemi, J.,Metsa-Ketela, M. Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis. Proc.Natl.Acad.Sci.USA, 112:9866-9871, 2015 Cited by PubMed: 26216966 DOI: 10.1073/pnas.1501765112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation