7OWB

Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB

Summary for 7OWB

Entry DOI	10.2210/pdb7owb/pdb
Related	1TW2
Descriptor	Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywords	carminomycin-4-o-methyltransferase variant; chimeragenesis; aclacinomycin 10-hydroxylase, biosynthetic protein
Biological source	Streptomyces peucetius More
Total number of polymer chains	1
Total formula weight	41258.71
Authors	Dinis, P.,MetsaKetela, M. (deposition date: 2021-06-17, release date: 2022-07-13, Last modification date: 2024-02-07)
Primary citation	Dinis, P.,Tirkkonen, H.,Wandi, B.N.,Siitonen, V.,Niemi, J.,Grocholski, T.,Metsa-Ketela, M. Evolution-inspired engineering of anthracycline methyltransferases. Pnas Nexus, 2:pgad009-pgad009, 2023 Cited by PubMed: 36874276 DOI: 10.1093/pnasnexus/pgad009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation