PDB: 10530 件ウェブページステータス検索Chemie searchBIRD

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8URF	Crystal Structure of human ASGR2 CRD (Carbohydrate Recognition Domain) bound to 8G8 Fab 分子名称: 8G8 Fab Heavy Chain, 8G8 Fab Light Chain, Asialoglycoprotein receptor 2, ... 著者 Sampathumar, P, Li, Y. 登録日 2023-10-25 公開日 2024-06-19 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Targeted protein degradation systems to enhance Wnt signaling. Elife, 13, 2024
5J6A	Crystal structure of pyruvate dehydrogenase kinase isoform 2 in complex with inhibitor PS46 分子名称: (3S)-3-amino-4-[4-({2-[(2,4-dihydroxyphenyl)sulfonyl]-2H-isoindol-5-yl}amino)piperidin-1-yl]-4-oxobutanamide, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 著者 Gui, W.J, Tso, S.C, Chuang, J.L, Wu, C.Y, Qi, X, Wynn, R.M, Chuang, D.T. 登録日 2016-04-04 公開日 2017-01-25 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.045 Å) 主引用文献 Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors. J. Med. Chem., 60, 2017
9B7F	S_SAD structure of HEWL using lossless default compression 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... 著者 Jakoncic, J, Bernstein, H.J, Soares, A.S, Horvat, K. 登録日 2024-03-27 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Investigation of fast and efficient lossless compression algorithms for macromolecular crystallography experiments To Be Published
2PJ8	CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Aminomethyl-phenyl)-3-{[(R)-1-(biphenyl-4-sulfonylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-propionic acid COMPLEX 分子名称: (2S)-2-[3-(AMINOMETHYL)PHENYL]-3-[(R)-{(1R)-1-[(BIPHENYL-4-YLSULFONYL)AMINO]-2-METHYLPROPYL}(HYDROXY)PHOSPHORYL]PROPANOIC ACID, Carboxypeptidase B, ZINC ION 著者 Adler, M, Whitlow, M. 登録日 2007-04-15 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of potent selective peptide mimetics bound to carboxypeptidase B. Acta Crystallogr.,Sect.D, 64, 2008
5IYE	Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 resolution 分子名称: DNA (5'-D(*CP*CP*CP*GP*GP*GP*TP*AP*CP*CP*CP*GP*GP*G)-3'), ZINC ION 著者 Karthik, S, Thirugnanasambandam, A, Mandal, P.K, Gautham, N. 登録日 2016-03-24 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.694 Å) 主引用文献 Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 angstrom resolution. Nucleosides Nucleotides Nucleic Acids, 36, 2017
5IYG	Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 resolution 分子名称: DNA (5'-D(*CP*CP*CP*GP*GP*GP*TP*AP*CP*CP*CP*GP*GP*G)-3') 著者 Karthik, S, Thirugnanasambandam, A, Mandal, P.K, Gautham, N. 登録日 2016-03-24 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 angstrom resolution. Nucleosides Nucleotides Nucleic Acids, 36, 2017
5IYJ	Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 resolution 分子名称: DNA (5'-D(*CP*CP*CP*GP*GP*GP*TP*AP*CP*CP*CP*GP*GP*G)-3') 著者 Karthik, S, Thirugnanasambandam, A, Mandal, P.K, Gautham, N. 登録日 2016-03-24 公開日 2017-03-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.701 Å) 主引用文献 Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 angstrom resolution. Nucleosides Nucleotides Nucleic Acids, 36, 2017
4YZC	Crystal structure of pIRE1alpha in complex with staurosporine 分子名称: STAUROSPORINE, Serine/threonine-protein kinase/endoribonuclease IRE1 著者 Concha, N.O. 登録日 2015-03-24 公開日 2015-11-11 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.494 Å) 主引用文献 Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity. Mol.Pharmacol., 88, 2015
9B7E	S_SAD structure of HEWL using lossy compression data with a compression ratio of 422 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Lysozyme C, ... 著者 Jakoncic, J, Bernstein, H.J, Soares, A.S, Horvat, K. 登録日 2024-03-27 公開日 2024-04-10 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Investigation of fast and efficient lossless compression algorithms for macromolecular crystallography experiments To Be Published
9AVL	Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-04 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
9AVG	Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-02 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
1ZQ5	Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404 分子名称: 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN, ACETATE ION, Aldo-keto reductase family 1 member C3, ... 著者 Qiu, W, Zhou, M, Ghanmi, D, Luu-The, V, Labrie, F, Lin, S.X. 登録日 2005-05-18 公開日 2006-12-12 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.3 Å) 主引用文献 Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 282, 2007
9AXF	Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-06 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
9AYF	Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-03-07 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
9ASB	Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs 分子名称: (19R,22S,25R)-22,25,26-trihydroxy-16,22-dioxo-17,21,23-trioxa-22lambda~5~-phosphahexacosan-19-yl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Zuo, H, Park, J, Frangaj, A, Ye, J, Lu, G, Manning, J.J, Asher, W.B, Lu, Z, Hu, G, Wang, L, Mendez, J, Eng, E, Zhang, Z, Lin, X, Grasucci, R, Hendrickson, W.A, Clarke, O.B, Javitch, J.A, Conigrave, A.D, Fan, Q.R. 登録日 2024-02-24 公開日 2024-04-17 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Promiscuous G-protein activation by the calcium-sensing receptor. Nature, 629, 2024
5K2H	Structure of GNNQQNY from yeast prion Sup35 in space group P212121 determined by MicroED 分子名称: Eukaryotic peptide chain release factor GTP-binding subunit 著者 Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. 登録日 2016-05-18 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 ELECTRON CRYSTALLOGRAPHY (1.05 Å) 主引用文献 Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc.Natl.Acad.Sci.USA, 113, 2016
2PJA	CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 3-{[(R)-1-((S)-2-Benzyloxycarbonylamino-3-phenyl-propionylamino)-2-methyl-propyl]-hydroxy-phosphinoyl}-2-(3-guanidino-phenyl)-propionic acid COMPLEX 分子名称: (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(R)-[(1R)-1-({N-[(BENZYLOXY)CARBONYL]-L-PHENYLALANYL}AMINO)-2-METHYLPROPYL](HYDROXY)PHOSPHORYL]PROPANOIC ACID, Carboxypeptidase B, ZINC ION 著者 Adler, M, Whitlow, M. 登録日 2007-04-15 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structures of potent selective peptide mimetics bound to carboxypeptidase B. Acta Crystallogr.,Sect.D, 64, 2008
2PIZ	CRYSTAL STRUCTURE OF ACTIVATED PORCINE PANCREATIC CARBOXYPEPTIDASE B 2-(3-Guanidino-phenyl)-3-[hydroxy-(3-phenyl-propyl)-phosphinoyl]-propionic acid COMPLEX 分子名称: (2S)-2-(3-{[AMINO(IMINO)METHYL]AMINO}PHENYL)-3-[(S)-HYDROXY(3-PHENYLPROPYL)PHOSPHORYL]PROPANOIC ACID, Carboxypeptidase B, ZINC ION 著者 Adler, M, Whitlow, M. 登録日 2007-04-15 公開日 2008-01-22 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of potent selective peptide mimetics bound to carboxypeptidase B. Acta Crystallogr.,Sect.D, 64, 2008
5ELY	X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with a hydroxamate inhibitor JHU242 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(2~{R})-2-carboxy-5-(oxidanylamino)-5-oxidanylidene-pentyl]benzoic acid, ... 著者 Barinka, C, Novakova, Z, Pavlicek, J. 登録日 2015-11-05 公開日 2016-04-27 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.81 Å) 主引用文献 Unprecedented Binding Mode of Hydroxamate-Based Inhibitors of Glutamate Carboxypeptidase II: Structural Characterization and Biological Activity. J.Med.Chem., 59, 2016
5JRL	Crystal Structure of the Sphingopyxin I Lasso Peptide Isopeptidase SpI-IsoP (Native) 分子名称: Dipeptidyl aminopeptidases/acylaminoacyl-peptidases-like protein 著者 Fage, C.D, Hegemann, J.D, Bange, G, Marahiel, M.A. 登録日 2016-05-06 公開日 2016-09-14 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase. Angew.Chem.Int.Ed.Engl., 55, 2016
5K2F	Structure of NNQQNY from yeast prion Sup35 with cadmium acetate determined by MicroED 分子名称: ACETATE ION, CADMIUM ION, Eukaryotic peptide chain release factor GTP-binding subunit 著者 Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S. 登録日 2016-05-18 公開日 2016-09-14 最終更新日 2024-03-06 実験手法 ELECTRON CRYSTALLOGRAPHY (1 Å) 主引用文献 Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED. Proc.Natl.Acad.Sci.USA, 113, 2016
2OWO	Last Stop on the Road to Repair: Structure of E.coli DNA Ligase Bound to Nicked DNA-Adenylate 分子名称: 26-MER, 5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*(OMC)P*C)-3', 5'-D(*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*AP*TP*G)-3', ... 著者 Shuman, S, Nandakumar, J, Nair, P.A. 登録日 2007-02-16 公開日 2007-05-15 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Last Stop on the Road to Repair: Structure of E. coli DNA Ligase Bound to Nicked DNA-Adenylate. Mol.Cell, 26, 2007
7L2G	NMR solution structure of Nak1 from the Necator americanus hookworm 分子名称: ShTK domain protein 著者 Smallwood, T.B, Rosengren, K.J, Clark, R.J. 登録日 2020-12-17 公開日 2021-10-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo. J.Biol.Chem., 297, 2021
8XAW	Cryo-EM structure of an anti-phage defense complex bound to AMPPNP and DNA at state 1 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding protein, DUF4297, ... 著者 An, Q, Deng, Z. 登録日 2023-12-05 公開日 2024-06-05 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.73 Å) 主引用文献 Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex. Cell Res., 2024
8XAX	Cryo-EM structure of an anti-phage defense complex bound to AMPPNP and DNA at state 2 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding protein, DUF4297, ... 著者 An, Q, Deng, Z. 登録日 2023-12-05 公開日 2024-06-05 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (2.92 Å) 主引用文献 Molecular and structural basis of an ATPase-nuclease dual-enzyme anti-phage defense complex. Cell Res., 2024

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