1ZQ5
Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404
Summary for 1ZQ5
Entry DOI | 10.2210/pdb1zq5/pdb |
Related | 1XF0 |
Descriptor | Aldo-keto reductase family 1 member C3, ACETATE ION, 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN, ... (5 entities in total) |
Functional Keywords | (alpha/beta)8 barrel, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P42330 |
Total number of polymer chains | 1 |
Total formula weight | 38094.20 |
Authors | Qiu, W.,Zhou, M.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X. (deposition date: 2005-05-18, release date: 2006-12-12, Last modification date: 2023-08-23) |
Primary citation | Qiu, W.,Zhou, M.,Mazumdar, M.,Azzi, A.,Ghanmi, D.,Luu-The, V.,Labrie, F.,Lin, S.X. Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 282:8368-8379, 2007 Cited by PubMed: 17166832DOI: 10.1074/jbc.M606784200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.3 Å) |
Structure validation
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