1ZQ5
Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Aldo-keto reductase family 1 member C3 | polymer | 323 | 36896.2 | 1 | UniProt (P42330) Pfam (PF00248) | Homo sapiens (human) | 17beta-hydroxysteroid dehydrogenase type 5; Trans-1,2- dihydrobenzene-1,2-diol dehydrogenase; Chlordecone reductase homolog HAKRb; HA1753; Dihydrodiol dehydrogenase, type I; Dihydrodiol dehydrogenase 3; DD3; 3-alpha-hydroxysteroid dehydrogenase; 3alpha-HSD; Prostaglandin F synthase |
| 2 | B (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 3 | C (A) | 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN | non-polymer | 395.5 | 1 | Chemie (E04) PubChem (9822061) PubChem (11987804) PubChem (22983993) PubChem (124222777) PubChem (59048321) | |||
| 4 | D (A) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 1 | Chemie (NAP) PubChem (5885) PubChem (46936685) PubChem (4412) PubChem (90473931) PubChem (91972139) PubChem (145946263) PubChem (153311489) PubChem (174001641) PubChem (71717786) PubChem (165382010) | |||
| 5 | E (A) | water | water | 18.0 | 313 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36896.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1198.0 | |
| All* | Total formula weight | 38094.2 |
