4YZC

Crystal structure of pIRE1alpha in complex with staurosporine

Summary for 4YZC

• Entry DOI: 10.2210/pdb4yzc/pdb
• Related: 4YZD
• Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1, STAUROSPORINE (3 entities in total)
• Functional Keywords: ire1, inhibitor, staurosporine, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane ; Single-pass type I membrane protein : O75460
• Total number of polymer chains: 2
• Total formula weight: 94634.07

Authors

Concha, N.O. (deposition date: 2015-03-24, release date: 2015-11-11, Last modification date: 2023-09-27)

• Primary citation: Concha, N.O.,Smallwood, A.,Bonnette, W.,Totoritis, R.,Zhang, G.,Federowicz, K.,Yang, J.,Qi, H.,Chen, S.,Campobasso, N.,Choudhry, A.E.,Shuster, L.E.,Evans, K.A.,Ralph, J.,Sweitzer, S.,Heerding, D.A.,Buser, C.A.,Su, D.S.,DeYoung, M.P.; Long-Range Inhibitor-Induced Conformational Regulation of Human IRE1 alpha Endoribonuclease Activity.; Mol.Pharmacol., 88:1011-1023, 2015; PubMed: 26438213; DOI: 10.1124/mol.115.100917

Experimental method

X-RAY DIFFRACTION (2.494 Å)