PDB: 95574 件ウェブページステータス検索Chemie searchBIRD

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7P0F	Crystal structure of a CGRP receptor ectodomain heterodimer bound to macrocyclic inhibitor HTL0028125 分子名称: (1S,10R,23E)-12-methyl-10-[(7-methyl-1H-indazol-5-yl)methyl]-15,18,21-trioxa-5,9,12,27,29-pentazapentacyclo[23.5.2.11,4.13,7.028,31]tetratriaconta-3(33),4,6,23,25(32),26,28(31)-heptaene-8,11,30-trione, Maltose/maltodextrin-binding periplasmic protein,Receptor activity-modifying protein 1,Calcitonin gene-related peptide type 1 receptor, TETRAETHYLENE GLYCOL, ... 著者 Southall, S.M, Watson, S.P. 登録日 2021-06-29 公開日 2022-06-15 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes. Acs Chem Neurosci, 13, 2022
6HRF	Straight filament from sporadic Alzheimer's disease brain 分子名称: Microtubule-associated protein tau 著者 Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M. 登録日 2018-09-26 公開日 2018-10-10 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold. Acta Neuropathol., 136, 2018
6XRZ	The 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome 分子名称: Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome 著者 Zhang, K, Zheludev, I, Hagey, R, Wu, M, Haslecker, R, Hou, Y, Kretsch, R, Pintilie, G, Rangan, R, Kladwang, W, Li, S, Pham, E, Souibgui, C, Baric, R, Sheahan, T, Souza, V, Glenn, J, Chiu, W, Das, R. 登録日 2020-07-14 公開日 2020-08-19 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Cryo-electron Microscopy and Exploratory Antisense Targeting of the 28-kDa Frameshift Stimulation Element from the SARS-CoV-2 RNA Genome. Biorxiv, 2020
6WJC	Muscarinic acetylcholine receptor 1 - muscarinic toxin 7 complex 分子名称: (1R,5S)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL (2R)-3-HYDROXY-2-PHENYLPROPANOATE, ACETAMIDE, CHOLESTEROL HEMISUCCINATE, ... 著者 Maeda, S, Kobilka, B.K. 登録日 2020-04-13 公開日 2020-07-08 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Structure and selectivity engineering of the M1muscarinic receptor toxin complex. Science, 369, 2020
7PD9	Crystal structure of CD73 in complex with riboflavin in the open form 分子名称: 5'-nucleotidase, CALCIUM ION, DIMETHYL SULFOXIDE, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-04 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PCP	Crystal structure of CD73 in complex with 5-iodouracil in the open form 分子名称: 5'-nucleotidase, 5-IODOURACIL, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-03 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.377 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
7PBY	Crystal structure of CD73 in complex with 4-nitrocatechol in the open form 分子名称: 4-NITROCATECHOL, 5'-nucleotidase, CALCIUM ION, ... 著者 Scaletti, E.R, Strater, N. 登録日 2021-08-02 公開日 2021-10-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.13 Å) 主引用文献 Substrate binding modes of purine and pyrimidine nucleotides to human ecto-5'-nucleotidase (CD73) and inhibition by their bisphosphonic acid derivatives. Purinergic Signal, 17, 2021
6HAL	Human carbonmonoxy hemoglobin SFX dataset 分子名称: CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... 著者 Doak, B, Gorel, A, Foucar, L, Barends, T.R.M, Gruenbein, M.L, Hilpert, M, Kloos, M, Nass Kovacs, G, Roome, C.M, Shoeman, R.L, Stricker, M, Tono, K, You, D, Ueda, K, Sherrell, D.A, Owen, R.L, Schlichting, I. 登録日 2018-08-07 公開日 2018-10-17 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Crystallography on a chip - without the chip: sheet-on-sheet sandwich. Acta Crystallogr D Struct Biol, 74, 2018
7Q3V	Re-refined structure of a type III antifreeze protein isoform HPLC 12 分子名称: Type-3 ice-structuring protein HPLC 12 著者 Mikhailovskii, O, Xue, Y, Jia, Z, Skrynnikov, N.R. 登録日 2021-10-28 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Modeling a unit cell: crystallographic refinement procedure using the biomolecular MD simulation platform Amber. Iucrj, 9, 2022
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area 分子名称: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.71 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide 分子名称: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... 著者 Clements, J.H, Stephen, F.M. 登録日 2011-05-29 公開日 2011-11-02 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
4RGW	Crystal Structure of a TAF1-TAF7 Complex in Human Transcription Factor IID 分子名称: GLYCEROL, Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 7 著者 Wang, H, Curran, E.C, Hinds, T.R, Wang, E.H, Zheng, N. 登録日 2014-09-30 公開日 2014-12-03 最終更新日 2014-12-17 実験手法 X-RAY DIFFRACTION (2.301 Å) 主引用文献 Crystal structure of a TAF1-TAF7 complex in human transcription factor IID reveals a promoter binding module. Cell Res., 24, 2014
3NB6	Crystal structure of Aquifex aeolicus peptidoglycan glycosyltransferase in complex with Methylphosphoryl Neryl Moenomycin 分子名称: Penicillin-binding protein 1A 著者 Sliz, P, Yuan, Y, Walker, S, Kahne, D. 登録日 2010-06-02 公開日 2011-05-18 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. Acs Chem.Biol., 5, 2010
7ALC	human GCH-GFRP stimulatory complex 分子名称: GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, PHENYLALANINE, ... 著者 Ebenhoch, R, Nar, H. 登録日 2020-10-06 公開日 2021-10-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.726 Å) 主引用文献 A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
7ALB	human GCH-GFRP stimulatory complex 7-deaza-GTP bound 分子名称: 7-deaza-GTP, GTP cyclohydrolase 1, GTP cyclohydrolase 1 feedback regulatory protein, ... 著者 Ebenhoch, R, Nar, H. 登録日 2020-10-06 公開日 2021-10-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (1.979 Å) 主引用文献 A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I. Proc.Natl.Acad.Sci.USA, 117, 2020
7PPN	SHP2 catalytic domain in complex with CD28 (183-198) phosphopeptide (pTyr-191, p-Thr-195) 分子名称: GLYCEROL, T-cell-specific surface glycoprotein CD28, Tyrosine-protein phosphatase non-receptor type 11,Tyrosine-protein phosphatase non-receptor type 11 著者 Sok, P, Zeke, A, Remenyi, A. 登録日 2021-09-14 公開日 2022-09-07 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural insights into the pSer/pThr dependent regulation of the SHP2 tyrosine phosphatase in insulin and CD28 signaling. Nat Commun, 13, 2022
3S8R	Crystal Structures of Glutaryl 7-Aminocephalosporanic Acid Acylase: Insight into Autoproteolytic Activation 分子名称: GLYCEROL, Glutaryl-7-aminocephalosporanic-acid acylase 著者 Kim, J.K, Yang, I.S, Park, S.S, Kim, K.H. 登録日 2011-05-30 公開日 2011-07-06 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activation. Biochemistry, 42, 2003
6I2I	Refined 13pf Hela Cell Tubulin microtubule (EML4-NTD decorated) 分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... 著者 Atherton, J.M, Moores, C.A. 登録日 2018-11-01 公開日 2019-08-28 最終更新日 2024-05-15 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Mitotic phosphorylation by NEK6 and NEK7 reduces the microtubule affinity of EML4 to promote chromosome congression. Sci.Signal., 12, 2019
4RZD	Crystal Structure of a PreQ1 Riboswitch 分子名称: 7-DEAZA-7-AMINOMETHYL-GUANINE, PreQ1-III Riboswitch (Class 3) 著者 Wedekind, J.E, Liberman, J.A, Salim, M. 登録日 2014-12-20 公開日 2015-07-01 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Structural analysis of a class III preQ1 riboswitch reveals an aptamer distant from a ribosome-binding site regulated by fast dynamics. Proc.Natl.Acad.Sci.USA, 112, 2015
3U1H	Crystal structure of IPMDH from the last common ancestor of Bacillus 分子名称: 3-isopropylmalate dehydrogenase 著者 Haaning, S, Hobbs, J.K, Monk, C.R, Arcus, V.L. 登録日 2011-09-29 公開日 2011-11-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 On the Origin and Evolution of Thermophily: Reconstruction of Functional Precambrian Enzymes from Ancestors of Bacillus MOL.BIOL.EVOL., 2011
6I41	Co-crystal structure of human SPOP MATH domain (wild-type) and human BRD3 fragment 分子名称: Bromodomain-containing protein 3, Speckle-type POZ protein 著者 Ostertag, M.S, Popowicz, G.M, Sattler, M. 登録日 2018-11-08 公開日 2019-05-08 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural Insights into BET Client Recognition of Endometrial and Prostate Cancer-Associated SPOP Mutants. J.Mol.Biol., 431, 2019
8PBL	E. coli RNA polymerase elongation complex stalled at thymine dimer lesion 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Woodgate, J, Zenkin, N. 登録日 2023-06-09 公開日 2023-10-25 最終更新日 2024-03-06 実験手法 ELECTRON MICROSCOPY (2.87 Å) 主引用文献 Translation selectively destroys non-functional transcription complexes. Nature, 626, 2024
3U0J	Crystal structure of ADP-ribosyltransferase HopU1 of Pseudomonas syringae pv. Tomato DC3000 分子名称: Type III effector HopU1 著者 Lin, Y, Yang, H, Wang, P, Xu, Y. 登録日 2011-09-28 公開日 2011-11-02 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity J.Biol.Chem., 286, 2011
4MGR	The crystal structure of Bacillus subtilis GabR, an autorepressor and PLP- and GABA-dependent transcriptional activator of gabT 分子名称: ACETATE ION, HTH-type transcriptional regulatory protein GabR, IMIDAZOLE, ... 著者 Wu, R, Edayathumangalam, R, Garcia, R, Wang, Y, Wang, W, Kreinbring, C.A, Bach, A, Liao, J, Stone, T, Terwilliger, T, Hoang, Q.Q, Belitsky, B.R, Petsko, G.A, Ringe, D, Liu, D. 登録日 2013-08-28 公開日 2013-10-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Crystal structure of Bacillus subtilis GabR, an autorepressor and transcriptional activator of gabT. Proc.Natl.Acad.Sci.USA, 110, 2013
3UBP	DIAMIDOPHOSPHATE INHIBITED BACILLUS PASTEURII UREASE 分子名称: DIAMIDOPHOSPHATE, NICKEL (II) ION, PROTEIN (UREASE ALPHA SUBUNIT), ... 著者 Benini, S, Rypniewski, W.R, Wilson, K.S, Miletti, S, Mangani, S, Ciurli, S. 登録日 1998-12-16 公開日 1999-12-17 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: why urea hydrolysis costs two nickels. Structure Fold.Des., 7, 1999

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