7OJI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oji by Molmil](/molmil-images/mine/7oji) | ABCG2 topotecan turnover-2 state | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, ADENOSINE-5'-TRIPHOSPHATE, Broad substrate specificity ATP-binding cassette transporter ABCG2, ... | 著者 | Yu, Q, Ni, D, Kowal, J, Manolaridis, I, Jackson, S.M, Stahlberg, H, Locher, K.P. | 登録日 | 2021-05-16 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism. Nat Commun, 12, 2021
|
|
7OZ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oz1 by Molmil](/molmil-images/mine/7oz1) | Cryo-EM structure of ABCG1 E242Q mutant with ATP and cholesteryl hemisuccinate bound | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Skarda, L, Kowal, J, Locher, K.P. | 登録日 | 2021-06-25 | 公開日 | 2021-09-22 | 最終更新日 | 2021-09-29 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structure of the Human Cholesterol Transporter ABCG1. J.Mol.Biol., 433, 2021
|
|
7P06
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p06 by Molmil](/molmil-images/mine/7p06) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in outward-facing conformation with ADP-orthovanadate/ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ADP ORTHOVANADATE, MAGNESIUM ION, ... | 著者 | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | 登録日 | 2021-06-29 | 公開日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (3.77 Å) | 主引用文献 | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
|
|
7P05
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p05 by Molmil](/molmil-images/mine/7p05) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP and rhodamine 6G | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs, ... | 著者 | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | 登録日 | 2021-06-29 | 公開日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (3.13 Å) | 主引用文献 | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
|
|
7P03
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p03 by Molmil](/molmil-images/mine/7p03) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation without nucleotides | 分子名称: | Pleiotropic ABC efflux transporter of multiple drugs | 著者 | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | 登録日 | 2021-06-29 | 公開日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
|
|
7P04
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p04 by Molmil](/molmil-images/mine/7p04) | Cryo-EM structure of Pdr5 from Saccharomyces cerevisiae in inward-facing conformation with ADP/ATP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Pleiotropic ABC efflux transporter of multiple drugs | 著者 | Szewczak-Harris, A, Wagner, M, Du, D, Schmitt, L, Luisi, B.F. | 登録日 | 2021-06-29 | 公開日 | 2021-11-10 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5. Nat Commun, 12, 2021
|
|
7OTI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7oti by Molmil](/molmil-images/mine/7oti) | Structure of ABCB1/P-glycoprotein in apo state | 分子名称: | Multidrug resistance protein 1A | 著者 | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | 登録日 | 2021-06-10 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
|
|
7O9W
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7o9w by Molmil](/molmil-images/mine/7o9w) | Encequidar-bound human P-glycoprotein in complex with UIC2-Fab | 分子名称: | Multidrug resistance protein 1, UIC2 Fab-fragment heavy chain, UIC2 Fab-fragment light chain, ... | 著者 | Nosol, K, Locher, K.P. | 登録日 | 2021-04-17 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-26 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Discovery and Characterization of Potent Dual P-Glycoprotein and CYP3A4 Inhibitors: Design, Synthesis, Cryo-EM Analysis, and Biological Evaluations. J.Med.Chem., 65, 2022
|
|
7OTG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7otg by Molmil](/molmil-images/mine/7otg) | Structure of ABCB1/P-glycoprotein in the presence of the CFTR potentiator ivacaftor | 分子名称: | Multidrug resistance protein 1A, N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide | 著者 | Ford, R.C, Barbieri, A, Thonghin, N, Shafi, T, Prince, S.M, Collins, R.F. | 登録日 | 2021-06-10 | 公開日 | 2021-12-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (5.4 Å) | 主引用文献 | Structure of ABCB1/P-Glycoprotein in the Presence of the CFTR Potentiator Ivacaftor. Membranes (Basel), 11, 2021
|
|
7OW8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7ow8 by Molmil](/molmil-images/mine/7ow8) | CryoEM structure of the ABC transporter BmrA E504A mutant in complex with ATP-Mg | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Multidrug resistance ABC transporter ATP-binding/permease protein BmrA | 著者 | Gobet, A, Schoehn, G, Falson, P, Chaptal, V. | 登録日 | 2021-06-17 | 公開日 | 2022-01-19 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Substrate-bound and substrate-free outward-facing structures of a multidrug ABC exporter. Sci Adv, 8, 2022
|
|
7O80
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7o80 by Molmil](/molmil-images/mine/7o80) | Rabbit 80S ribosome in complex with eRF1 and ABCE1 stalled at the STOP codon in the mutated SARS-CoV-2 slippery site | 分子名称: | 18S rRNA, 28S rRNA, 40S ribosomal protein S11, ... | 著者 | Bhatt, P.R, Scaiola, A, Leibundgut, M.A, Atkins, J.F, Ban, N. | 登録日 | 2021-04-14 | 公開日 | 2021-06-02 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome. Science, 372, 2021
|
|
7VGF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vgf by Molmil](/molmil-images/mine/7vgf) | cryo-EM structure of AMP-PNP bound human ABCB7 | 分子名称: | Iron-sulfur clusters transporter ABCB7, mitochondrial, MAGNESIUM ION, ... | 著者 | Yan, Q, Yang, X, Shen, Y. | 登録日 | 2021-09-16 | 公開日 | 2022-02-16 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structure of AMP-PNP-bound human mitochondrial ATP-binding cassette transporter ABCB7. J.Struct.Biol., 214, 2022
|
|
7VLT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vlt by Molmil](/molmil-images/mine/7vlt) | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | 分子名称: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
|
|
7VLR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vlr by Molmil](/molmil-images/mine/7vlr) | Structure of SUR2B in complex with Mg-ATP/ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
|
|
7VLU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vlu by Molmil](/molmil-images/mine/7vlu) | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
|
|
7VLS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vls by Molmil](/molmil-images/mine/7vls) | Structure of SUR2B in complex with MgATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
|
|
7VX8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vx8 by Molmil](/molmil-images/mine/7vx8) | Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1 | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1 | 著者 | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2021-11-12 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
|
|
7VWC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vwc by Molmil](/molmil-images/mine/7vwc) | Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1 | 分子名称: | Peroxisomal Membrane Protein related,ATP-binding cassette sub-family D member 1, [(2R)-3-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-2-oxidanyl-propyl] octadecanoate | 著者 | Chen, Z.P, Xu, D, Wang, L, Mao, Y.X, Yang, L, Cheng, M.T, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2021-11-10 | 公開日 | 2022-05-18 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | 主引用文献 | Structural basis of substrate recognition and translocation by human very long-chain fatty acid transporter ABCD1. Nat Commun, 13, 2022
|
|
7VR5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vr5 by Molmil](/molmil-images/mine/7vr5) | Crystal structure of CmABCB1 W114Y/W161Y/W363Y/W364Y/M391W (4WY/M391W) mutant | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DECYL-BETA-D-MALTOPYRANOSIDE, Probable ATP-dependent transporter ycf16 | 著者 | Inoue, Y, Ogawa, H, Kato, H. | 登録日 | 2021-10-21 | 公開日 | 2022-09-07 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy. Protein Sci., 31, 2022
|
|
7V8I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v8i by Molmil](/molmil-images/mine/7v8i) | LolCD(E171Q)E with bound AMPPNP in nanodiscs | 分子名称: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE, ... | 著者 | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
|
|
7V8M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v8m by Molmil](/molmil-images/mine/7v8m) | LolCDE-apo in nanodiscs | 分子名称: | Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, Lipoprotein-releasing system transmembrane protein LolE | 著者 | Luo, Q.S, Bei, W.W, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-08-31 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
|
|
7V8L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7v8l by Molmil](/molmil-images/mine/7v8l) | LolCDE with bound RcsF in nanodiscs | 分子名称: | (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolC, ... | 著者 | Bei, W.W, Luo, Q.S, Shi, H.G, Zhang, X.Z, Huang, Y.H. | 登録日 | 2021-08-23 | 公開日 | 2022-09-21 | 最終更新日 | 2023-10-04 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of LolCDE reveal the molecular mechanism of bacterial lipoprotein sorting in Escherichia coli. Plos Biol., 20, 2022
|
|
7VFJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vfj by Molmil](/molmil-images/mine/7vfj) | Cytochrome c-type biogenesis protein CcmABCD | 分子名称: | Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, Heme exporter protein C, ... | 著者 | Zhu, J.P, Zhang, K, Li, J, Zheng, W, Gu, M. | 登録日 | 2021-09-13 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.98 Å) | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states. Nat Commun, 13, 2022
|
|
7VFP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vfp by Molmil](/molmil-images/mine/7vfp) | Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | 登録日 | 2021-09-13 | 公開日 | 2022-11-09 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states. Nat Commun, 13, 2022
|
|
7W02
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w02 by Molmil](/molmil-images/mine/7w02) | Cryo-EM structure of ATP-bound ABCA3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Xie, T, Zhang, Z.K, Yue, J, Gong, X. | 登録日 | 2021-11-17 | 公開日 | 2022-04-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-EM structures of the human surfactant lipid transporter ABCA3. Sci Adv, 8, 2022
|
|