PDB: 1583 件ウェブページステータス検索Chemie searchBIRD

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2MOA	Solution NMR structure of peptide ImI1 (peak 2) 分子名称: Alpha-conotoxin ImI 著者 Heinis, C, Chen, S. 登録日 2014-04-24 公開日 2014-09-24 最終更新日 2023-11-15 実験手法 SOLUTION NMR 主引用文献 Dithiol amino acids can structurally shape and enhance the ligand-binding properties of polypeptides. Nat Chem, 6, 2014
8IKL	Cryo-EM structure of the CD97-G13 complex 分子名称: Adhesion G protein-coupled receptor E5, Guanine nucleotide-binding protein G(13) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Mao, C, Zhao, R, Dong, Y, Gao, M, Chen, L, Zhang, C, Xiao, P. 登録日 2023-02-28 公開日 2024-01-24 最終更新日 2024-02-14 実験手法 ELECTRON MICROSCOPY (2.33 Å) 主引用文献 Conformational transitions and activation of the adhesion receptor CD97. Mol.Cell, 84, 2024
2BYN	Crystal structure of apo AChBP from Aplysia californica 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAETHYLENE GLYCOL, SOLUBLE ACETYLCHOLINE RECEPTOR, ... 著者 Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. 登録日 2005-08-03 公開日 2005-10-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
2BYP	Crystal structure of Aplysia californica AChBP in complex with alpha- conotoxin ImI 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, ALPHA-CONOTOXIN IMI, SOLUBLE ACETYLCHOLINE RECEPTOR 著者 Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. 登録日 2005-08-03 公開日 2005-10-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
1I9B	X-RAY STRUCTURE OF ACETYLCHOLINE BINDING PROTEIN (ACHBP) 分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYLCHOLINE BINDING PROTEIN, CALCIUM ION 著者 Brejc, K, van Dijk, W.J, Klaassen, R, Schuurmans, M, van der Oost, J, Smit, A.B, Sixma, T.K. 登録日 2001-03-18 公開日 2001-05-16 最終更新日 2018-03-07 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature, 411, 2001
2BYQ	Crystal structure of Aplysia californica AChBP in complex with epibatidine 分子名称: EPIBATIDINE, SOLUBLE ACETYLCHOLINE RECEPTOR 著者 Hansen, S.B, Sulzenbacher, G, Huxford, T, Marchot, P, Taylor, P, Bourne, Y. 登録日 2005-08-03 公開日 2005-10-05 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (3.4 Å) 主引用文献 Structures of Aplysia Achbp Complexes with Nicotinic Agonists and Antagonists Reveal Distinctive Binding Interfaces and Conformations. Embo J., 24, 2005
3HKL	Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Muscle, skeletal receptor tyrosine protein kinase 著者 Stiegler, A.L, Hubbard, S.R. 登録日 2009-05-24 公開日 2009-08-25 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J.Mol.Biol., 393, 2009
8JXT	Histamine-bound H4R/Gi complex 分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... 著者 He, Y, Xia, R. 登録日 2023-07-01 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.07 Å) 主引用文献 Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
8JXX	Clobenpropit-bound H4R/Gi complex 分子名称: 3-(1~{H}-imidazol-4-yl)propyl ~{N}'-[(4-chlorophenyl)methyl]carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Xia, R. 登録日 2023-07-01 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.06 Å) 主引用文献 Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
8JXW	VUF6884-bound H4R/Gi complex 分子名称: 2-chloranyl-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Xia, R. 登録日 2023-07-01 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.01 Å) 主引用文献 Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
8JXV	Clozapine-bound H4R/Gi complex 分子名称: 3-chloranyl-6-(4-methylpiperazin-1-yl)-11~{H}-benzo[b][1,4]benzodiazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... 著者 He, Y, Xia, R. 登録日 2023-07-01 公開日 2024-03-20 最終更新日 2024-04-03 実験手法 ELECTRON MICROSCOPY (3.21 Å) 主引用文献 Structural basis of ligand recognition and design of antihistamines targeting histamine H 4 receptor. Nat Commun, 15, 2024
2NR1	TRANSMEMBRANE SEGMENT 2 OF NMDA RECEPTOR NR1, NMR, 10 STRUCTURES 分子名称: NR1 M2 著者 Gesell, J.J, Sun, W, Montal, M, Opella, S. 登録日 1997-12-22 公開日 1998-04-29 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 Structures of the M2 channel-lining segments from nicotinic acetylcholine and NMDA receptors by NMR spectroscopy. Nat.Struct.Biol., 6, 1999
5LG3	X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) in complex with chlorpromazine 分子名称: 3-(2-chloro-10H-phenothiazin-10-yl)-N,N-dimethylpropan-1-amine, Gamma-aminobutyric-acid receptor subunit beta-1 著者 Nys, M, Wijckmans, E, Farinha, A, Brams, M, Spurny, R, Ulens, C. 登録日 2016-07-05 公開日 2016-10-26 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.567 Å) 主引用文献 Allosteric binding site in a Cys-loop receptor ligand-binding domain unveiled in the crystal structure of ELIC in complex with chlorpromazine. Proc.Natl.Acad.Sci.USA, 113, 2016
5BRX	X-ray crystal structure of Aplysia californica (Ac-AChBP) in complex with 2-pyridyl azatricyclo[3.3.1.13,7]decane; 2-pyridylazaadamantane; 2-Aza (TI-8480) 分子名称: (2R,3S,5R,7S)-2-(pyridin-3-yl)-1-azatricyclo[3.3.1.1~3,7~]decane, SULFATE ION, Soluble acetylcholine receptor, ... 著者 Bobango, J, Sankaran, B, Park, J.F, Wu, J, Talley, T.T. 登録日 2015-06-01 公開日 2015-06-24 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Comparisons of Binding Affinities for Neuronal Nicotinic Receptors (NNRs) and AChBPs To Be Published
6LFO	Cryo-EM structure of a class A GPCR monomer 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
6LFM	Cryo-EM structure of a class A GPCR 分子名称: C-X-C chemokine receptor type 2, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Liu, Z.J, Hua, T, Liu, K.W, Wu, L.J. 登録日 2019-12-03 公開日 2020-09-02 最終更新日 2020-09-16 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of CXC chemokine receptor 2 activation and signalling. Nature, 585, 2020
7MTS	CryoEM Structure of mGlu2 - Gi Complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine, GLUTAMIC ACID, ... 著者 Seven, A.B, Barros-Alvarez, X, Skiniotis, G. 登録日 2021-05-13 公開日 2021-07-07 最終更新日 2021-07-28 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 G-protein activation by a metabotropic glutamate receptor. Nature, 595, 2021
6XOX	cryo-EM of human GLP-1R bound to non-peptide agonist LY3502970 分子名称: 3-[(1S,2S)-1-(5-[(4S)-2,2-dimethyloxan-4-yl]-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl)-2-methylcyclopropyl]-1,2,4-oxadiazol-5(4H)-one, Alpha subunit of Gs with N-terminus swapped with equivalent residues in Gi,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Glucagon-like peptide 1 receptor, ... 著者 Sun, B, Kobilka, B.K, Sloop, K.W, Feng, D, Kobilka, T.S. 登録日 2020-07-07 公開日 2020-11-18 最終更新日 2020-12-09 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist. Proc.Natl.Acad.Sci.USA, 117, 2020
6KPF	Cryo-EM structure of a class A GPCR with G protein complex 分子名称: 7-[(6aR,9R,10aR)-1-Hydroxy-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-3-yl]- 7-methyloctanenitrile, Cannabinoid receptor 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Li, X.T, Hua, T, Wu, L.J, Makriyannis, A, Shen, L, Wang, Y.X, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2022-04-27 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
6KPG	Cryo-EM structure of CB1-G protein complex 分子名称: (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol, Cannabinoid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Hua, T, Li, X.T, Wu, L.J, Makriyannis, A, Wang, Y.X, Shen, L, Liu, Z.J. 登録日 2019-08-15 公開日 2020-02-12 最終更新日 2020-03-11 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures. Cell, 180, 2020
5HE2	Bovine GRK2 in complex with Gbetagamma subunits and CCG224406 分子名称: (4~{S})-4-[3-[(2,6-dimethoxyphenyl)methylcarbamoyl]-4-fluoranyl-phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... 著者 Cato, M.C, Waninger-Saroni, J, Tesmer, J.J.G. 登録日 2016-01-05 公開日 2016-05-11 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59, 2016
2XUF	CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 ANTI COMPLEX (1 MTH) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-4-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE, ... 著者 Bourne, Y, Radic, Z, Taylor, P, Marchot, P. 登録日 2010-10-19 公開日 2010-12-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.55 Å) 主引用文献 Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
2XUJ	CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 SYN COMPLEX (1 MTH) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE, ... 著者 Bourne, Y, Radic, Z, Taylor, P, Marchot, P. 登録日 2010-10-19 公開日 2010-12-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.65 Å) 主引用文献 Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010
2Y2V	Nonaged form of Mouse Acetylcholinesterase inhibited by sarin-Update 分子名称: 1-ETHOXY-2-(2-METHOXYETHOXY)ETHANE, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, 2-ETHOXYETHANOL, ... 著者 Akfur, C, Artursson, E, Ekstrom, F. 登録日 2010-12-16 公開日 2011-11-30 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Methylphosphonate Adducts of Acetylcholinesterase Investigated by Time Correlated Single Photon Counting and X-Ray Crystallography To be Published
2XUK	CRYSTAL STRUCTURE OF MACHE-Y337A-TZ2PA6 SYN COMPLEX (10 MTH) 分子名称: 3,8-DIAMINO-6-PHENYL-5-[6-[1-[2-[(1,2,3,4-TETRAHYDRO-9-ACRIDINYL)AMINO]ETHYL]-1H-1,2,3-TRIAZOL-5-YL]HEXYL]-PHENANTHRIDINIUM, ACETYLCHOLINESTERASE 著者 Bourne, Y, Radic, Z, Taylor, P, Marchot, P. 登録日 2010-10-19 公開日 2010-12-08 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Conformational Remodeling of Femtomolar Inhibitor-Acetylcholinesterase Complexes in the Crystalline State J.Am.Chem.Soc., 132, 2010

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