6ZY6
| Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 2 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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6ZY8
| Cryo-EM structure of the entire Human topoisomerase II alpha in State 2 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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6ZY5
| Cryo-EM structure of the Human topoisomerase II alpha DNA-binding/cleavage domain in State 1 | 分子名称: | (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol -5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside, DNA (5'-D(*CP*GP*CP*GP*CP*AP*TP*CP*GP*TP*CP*AP*TP*CP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*GP*AP*TP*GP*AP*CP*GP*AP*TP*G)-3'), ... | 著者 | Vanden Broeck, A, Lamour, V. | 登録日 | 2020-07-30 | 公開日 | 2021-05-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for allosteric regulation of Human Topoisomerase II alpha. Nat Commun, 12, 2021
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1Y8R
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7AOA
| Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex | 分子名称: | Histone deacetylase 1, Histone-binding protein RBBP4, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-10-14 | 公開日 | 2020-11-11 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (19.4 Å) | 主引用文献 | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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1A5R
| STRUCTURE DETERMINATION OF THE SMALL UBIQUITIN-RELATED MODIFIER SUMO-1, NMR, 10 STRUCTURES | 分子名称: | SUMO-1 | 著者 | Bayer, P, Arndt, A, Metzger, S, Mahajan, R, Melchior, F, Jaenicke, R, Becker, J. | 登録日 | 1998-02-18 | 公開日 | 1998-10-14 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure determination of the small ubiquitin-related modifier SUMO-1. J.Mol.Biol., 280, 1998
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3RZW
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6D90
| Mammalian 80S ribosome with a double translocated CrPV-IRES, P-site tRNA and eRF1. | 分子名称: | 18S rRNA, 28S rRNA, 5.8S rRNA, ... | 著者 | Pisareva, V.P, Pisarev, A.V, Fernandez, I.S. | 登録日 | 2018-04-27 | 公開日 | 2018-06-06 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Dual tRNA mimicry in the Cricket Paralysis Virus IRES uncovers an unexpected similarity with the Hepatitis C Virus IRES. Elife, 7, 2018
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7AE1
| Cryo-EM structure of human RNA Polymerase III elongation complex 1 | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | 登録日 | 2020-09-17 | 公開日 | 2021-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7AE3
| Cryo-EM structure of human RNA Polymerase III elongation complex 3 | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | 登録日 | 2020-09-17 | 公開日 | 2021-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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6OLF
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7AEA
| Cryo-EM structure of human RNA Polymerase III elongation complex 2 | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | 著者 | Girbig, M, Misiaszek, A.D, Vorlaender, M.K, Mueller, C.W. | 登録日 | 2020-09-17 | 公開日 | 2021-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states. Nat.Struct.Mol.Biol., 28, 2021
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7ABI
| Human pre-Bact-2 spliceosome | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | 登録日 | 2020-09-07 | 公開日 | 2021-02-10 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
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7AO9
| Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex | 分子名称: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | 著者 | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-10-14 | 公開日 | 2020-11-11 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (6.1 Å) | 主引用文献 | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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7AO8
| Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex | 分子名称: | Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ... | 著者 | Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-10-14 | 公開日 | 2020-11-11 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | The topology of chromatin-binding domains in the NuRD deacetylase complex. Nucleic Acids Res., 48, 2020
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1WYW
| Crystal Structure of SUMO1-conjugated thymine DNA glycosylase | 分子名称: | CHLORIDE ION, G/T mismatch-specific thymine DNA glycosylase, MAGNESIUM ION, ... | 著者 | Baba, D, Maita, N, Jee, J.G, Uchimura, Y, Saitoh, H, Sugasawa, K, Hanaoka, F, Tochio, H, Hiroaki, H, Shirakawa, M. | 登録日 | 2005-02-17 | 公開日 | 2005-06-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal structure of thymine DNA glycosylase conjugated to SUMO-1. Nature, 435, 2005
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6RYU
| Nucleosome-CHD4 complex structure (two CHD4 copies) | 分子名称: | Chromodomain-helicase-DNA-binding protein 4,CHD4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | 著者 | Farnung, L, Ochmann, M, Cramer, P. | 登録日 | 2019-06-12 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
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6RYR
| Nucleosome-CHD4 complex structure (single CHD4 copy) | 分子名称: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | 著者 | Farnung, L, Ochmann, M, Cramer, P. | 登録日 | 2019-06-11 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
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6XOG
| Structure of SUMO1-ML786519 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOH
| Structure of SUMO1-ML00789344 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOI
| Structure of SUMO1-ML00752641 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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7DN3
| Structure of Human RNA Polymerase III elongation complex | 分子名称: | DNA (5'-D(P*TP*CP*GP*TP*CP*TP*GP*AP*TP*CP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*CP*GP*AP*GP*AP*TP*CP*AP*GP*AP*CP*GP*AP*GP*AP*TP*CP*GP*GP*G)-3'), DNA-directed RNA polymerase III subunit RPC1, ... | 著者 | Li, L, Yu, Z, Zhao, D, Ren, Y, Hou, H, Xu, Y. | 登録日 | 2020-12-08 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structure of human RNA polymerase III elongation complex. Cell Res., 31, 2021
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6Z2K
| The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | 分子名称: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-05-16 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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6Z2J
| The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex | 分子名称: | Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ... | 著者 | Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R. | 登録日 | 2020-05-16 | 公開日 | 2020-07-08 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure. Nat Commun, 11, 2020
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7WTW
| Cryo-EM structure of a human pre-40S ribosomal subunit - State RRP12-A3 | 分子名称: | 18S rRNA, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | 著者 | Cheng, J, Lau, B, Thoms, M, Ameismeier, M, Berninghausen, O, Hurt, E, Beckmann, R. | 登録日 | 2022-02-05 | 公開日 | 2022-10-19 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The nucleoplasmic phase of pre-40S formation prior to nuclear export. Nucleic Acids Res., 50, 2022
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