PDB: 202 件ウェブページステータス検索Chemie searchBIRD

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8GL9	Co-crystal structure of caPCNA bound to AOH1160 derivative 1LE 分子名称: CHLORIDE ION, N~2~-(naphthalene-1-carbonyl)-N-(2-phenoxyphenyl)-L-alpha-glutamine, Proliferating cell nuclear antigen 著者 Jossart, J, Kenjic, N, Malkas, L.H, Hickey, R.J, Perry, J.J. 登録日 2023-03-21 公開日 2023-07-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.81 Å) 主引用文献 Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30, 2023
8GLA	Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE 分子名称: CHLORIDE ION, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, Proliferating cell nuclear antigen 著者 Jossart, J, Perry, J.J. 登録日 2023-03-21 公開日 2023-07-26 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.77 Å) 主引用文献 Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30, 2023
6HVO	Crystal structure of human PCNA in complex with three peptides of p12 subunit of human polymerase delta 分子名称: DNA polymerase delta subunit 4, Proliferating cell nuclear antigen, SULFATE ION 著者 Gonzalez-Magana, A, Romano-Moreno, M, Rojas, A.L, Blanco, F.J, De Biasio, A. 登録日 2018-10-11 公開日 2019-01-23 最終更新日 2019-03-27 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 The p12 subunit of human polymerase delta uses an atypical PIP box for molecular recognition of proliferating cell nuclear antigen (PCNA). J.Biol.Chem., 294, 2019
9F6D	Human DNA polymerase epsilon bound to DNA and PCNA (open conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
9F6F	Human DNA polymerase epsilon bound to DNA and PCNA (closed conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.75 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
9F6E	Human DNA polymerase epsilon bound to DNA and PCNA (ajar conformation) 分子名称: 2',3'-dideoxyadenosine triphosphate, DNA nascent strand, DNA polymerase epsilon catalytic subunit A, ... 著者 Roske, J.J, Yeeles, J.T.P. 登録日 2024-05-01 公開日 2024-08-07 最終更新日 2024-08-21 実験手法 ELECTRON MICROSCOPY (3.74 Å) 主引用文献 Structural basis for processive daughter-strand synthesis and proofreading by the human leading-strand DNA polymerase Pol epsilon. Nat.Struct.Mol.Biol., 2024
5IY4	Crystal structure of human PCNA in complex with the PIP box of DVC1 分子名称: DVC1 PIP box, Proliferating cell nuclear antigen 著者 Jiang, T, Xu, M, Wang, Y. 登録日 2016-03-24 公開日 2016-06-08 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.945 Å) 主引用文献 Crystal structure of human PCNA in complex with the PIP box of DVC1 Biochem.Biophys.Res.Commun., 474, 2016
4L60	Structure of C81R Mutant PCNA Protein Defective in Mismatch Repair 分子名称: Proliferating cell nuclear antigen 著者 Washington, T, Boehm, E. 登録日 2013-06-11 公開日 2013-10-02 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3.003 Å) 主引用文献 Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair. Biochemistry, 52, 2013
4L6P	Structure of C22Y Mutant PCNA protein defective in DNA mismatch repair 分子名称: GLYCEROL, Proliferating cell nuclear antigen 著者 Washington, T, Boehm, E. 登録日 2013-06-12 公開日 2014-10-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Distinct structural alterations in proliferating cell nuclear antigen block DNA mismatch repair. Biochemistry, 52, 2013
3L0W	Structure of split monoubiquitinated PCNA with ubiquitin in position two 分子名称: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. 登録日 2009-12-10 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
7NV1	Human Pol Kappa holoenzyme with Ub-PCNA 分子名称: DNA Primer, DNA Template, DNA polymerase kappa, ... 著者 Lancey, C, De Biasio, A, Hamdan, S.M. 登録日 2021-03-15 公開日 2021-11-03 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (6.4 Å) 主引用文献 Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA. Nat Commun, 12, 2021
7NV0	Human Pol Kappa holoenzyme with wt PCNA 分子名称: DNA Primer, DNA Template, DNA polymerase kappa, ... 著者 Lancey, C, De Biasio, A, Hamdan, S.M. 登録日 2021-03-15 公開日 2021-11-10 最終更新日 2024-07-10 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Cryo-EM structure of human Pol kappa bound to DNA and mono-ubiquitylated PCNA. Nat Commun, 12, 2021
4YHR	Crystal Structure of Yeast Proliferating Cell Nuclear Antigen 分子名称: Proliferating cell nuclear antigen 著者 Litman, J.M, Nguyen, V.Q, Kondratick, C.M, Powers, K.T, Schnieders, M.J, Washington, M.T. 登録日 2015-02-27 公開日 2015-03-18 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.9502 Å) 主引用文献 Dead-End Elimination with a Polarizable Force Field Repacks PCNA Models from Low-Resolution X-ray Diffraction into Atomic Resolution Structures To be published
3P91	Crystal structure of Proliferating Cellular Nuclear Antigen from Entamoeba histolytica 分子名称: Proliferating cell nuclear antigen 著者 Lara-Gonzalez, S, Cardona-Felix, C.S, Brieba, L.G. 登録日 2010-10-15 公開日 2011-06-01 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Structure and biochemical characterization of proliferating cellular nuclear antigen from a parasitic protozoon. Acta Crystallogr.,Sect.D, 67, 2011
7O1F	PCNA from Chaetomium thermophilum in complex with PolD4 PIP peptide 分子名称: Peptide fragment from PolD4, Proliferating cell nuclear antigen, SODIUM ION 著者 Alphey, M.A, MacNeill, S, Yang, D. 登録日 2021-03-29 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.45 Å) 主引用文献 Non-canonical binding of the Chaetomium thermophilum PolD4 N-terminal PIP motif to PCNA involves Q-pocket and compact 2-fork plug interactions but no 3 10 helix. Febs J., 290, 2023
7O1E	Crystal structure of PCNA from Chaetomium thermophilum 分子名称: Proliferating cell nuclear antigen 著者 Alphey, M.A, MacNeill, S, Yang, D. 登録日 2021-03-29 公開日 2022-04-13 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.34 Å) 主引用文献 Non-canonical binding of the Chaetomium thermophilum PolD4 N-terminal PIP motif to PCNA involves Q-pocket and compact 2-fork plug interactions but no 3 10 helix. Febs J., 290, 2023
3L10	Structure of split monoubiquitinated PCNA with ubiquitin in position one 分子名称: Monoubiquitinated Proliferating cell nuclear antigen, Proliferating cell nuclear antigen 著者 Freudenthal, B.D, Gakhar, L, Ramaswamy, S, Washington, M.T. 登録日 2009-12-10 公開日 2010-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Structure of monoubiquitinated PCNA and implications for translesion synthesis and DNA polymerase exchange. Nat.Struct.Mol.Biol., 17, 2010
5YD8	Crystal structure of human PCNA in complex with APIM of human ZRANB3 分子名称: Proliferating cell nuclear antigen, ZRANB3 著者 Hashimoto, H, Tagata, R. 登録日 2017-09-12 公開日 2018-04-18 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction. Acta Crystallogr.,Sect.F, 74, 2018
3P87	Structure of human PCNA bound to RNASEH2B PIP box peptide 分子名称: Proliferating cell nuclear antigen, Ribonuclease H2 subunit B 著者 Bubeck, D, Reijns, M.A, Graham, S.C, Astell, K.R, Jones, E.Y, Jackson, A.P. 登録日 2010-10-13 公開日 2011-02-02 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.99 Å) 主引用文献 PCNA directs type 2 RNase H activity on DNA replication and repair substrates. Nucleic Acids Res., 39, 2011
5YCO	Complex structure of PCNA with UHRF2 分子名称: E3 ubiquitin-protein ligase UHRF2, GLYCEROL, Proliferating cell nuclear antigen, ... 著者 Wu, M, Chen, W, Hang, T, Wang, C, Zhang, X, Zang, J. 登録日 2017-09-07 公開日 2017-11-15 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 Structure insights into the molecular mechanism of the interaction between UHRF2 and PCNA. Biochem. Biophys. Res. Commun., 494, 2017
4ZTD	Crystal Structure of Human PCNA in complex with a TRAIP peptide 分子名称: ALA-GLY-ALA-GLY-ALA, ALA-PHE-GLN-ALA-LYS-LEU-ASP-THR-PHE-LEU-TRP-SER, Proliferating cell nuclear antigen 著者 Montoya, G, Mortuza, G.B, Blanco, F.J, Ibanez de Opakua, A. 登録日 2015-05-14 公開日 2015-12-16 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.199 Å) 主引用文献 TRAIP is a PCNA-binding ubiquitin ligase that protects genome stability after replication stress. J.Cell Biol., 212, 2016
3LX2	Crystal Structure analysis of PCNA from Thermococcus kodakaraensis tk0582 分子名称: DNA polymerase sliding clamp 2, SULFATE ION 著者 Ladner, J.E, Kelman, Z, Pan, M. 登録日 2010-02-24 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis. Proc.Natl.Acad.Sci.USA, 108, 2011
5ZUT	Crystal Structure of Yeast PCNA in Complex with N24 Peptide 分子名称: N24, Proliferating cell nuclear antigen 著者 Cheng, X.Y, Kuang, X.L, Zhou, Y, Xia, X.M, SU, Z.D. 登録日 2018-05-08 公開日 2018-05-30 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Crystal Structure of Yeast PCNA in Complex with N24 Peptide To Be Published
3LX1	Crystal Structure analysis of PCNA1 from Thermococcus kodakaraensis tk0535 分子名称: DNA polymerase sliding clamp 1, SULFATE ION 著者 Ladner, J.E, Kelman, Z, Pan, M. 登録日 2010-02-24 公開日 2011-01-26 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of two active proliferating cell nuclear antigens (PCNAs) encoded by Thermococcus kodakaraensis. Proc.Natl.Acad.Sci.USA, 108, 2011
5A6D	Proliferating Cell Nuclear Antigen, PCNA, from Thermococcus gammatolerans 分子名称: DNA POLYMERASE SLIDING CLAMP 著者 Venancio-Landeros, A, Cardona-Felix, C.S, Rudino-Pinera, E. 登録日 2015-06-25 公開日 2016-07-06 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Cloning, recombinant production and crystallographic structure of Proliferating Cell Nuclear Antigen from radioresistant archaeon Thermococcus gammatolerans. Biochem Biophys Rep, 8, 2016

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