8GLA

Co-crystal structure of caPCNA bound to the AOH1996 derivative, AOH1996-1LE

Summary for 8GLA

Entry DOI	10.2210/pdb8gla/pdb
Descriptor	Proliferating cell nuclear antigen, N-[2-(3-methoxyphenoxy)phenyl]-N~2~-(naphthalene-1-carbonyl)-L-alpha-glutamine, CHLORIDE ION (3 entities in total)
Functional Keywords	pcna, transcription-replication conflict, dna replication stress, dna repair, aoh1160, aoh1996, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	118457.79
Authors	Jossart, J.,Perry, J.J. (deposition date: 2023-03-21, release date: 2023-07-26, Last modification date: 2023-11-01)
Primary citation	Gu, L.,Li, M.,Li, C.M.,Haratipour, P.,Lingeman, R.,Jossart, J.,Gutova, M.,Flores, L.,Hyde, C.,Kenjic, N.,Li, H.,Chung, V.,Li, H.,Lomenick, B.,Von Hoff, D.D.,Synold, T.W.,Aboody, K.S.,Liu, Y.,Horne, D.,Hickey, R.J.,Perry, J.J.P.,Malkas, L.H. Small molecule targeting of transcription-replication conflict for selective chemotherapy. Cell Chem Biol, 30:1235-, 2023 Cited by PubMed: 37531956 DOI: 10.1016/j.chembiol.2023.07.001 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.77 Å)

Structure validation