PDB: 67 件ウェブページステータス検索Chemie searchBIRD

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5CCL	Crystal structure of SMYD3 with SAM and oxindole compound 分子名称: 1,2-ETHANEDIOL, 2-oxidanylidene-N-piperidin-4-yl-1,3-dihydroindole-5-carboxamide, Histone-lysine N-methyltransferase SMYD3, ... 著者 Boriack-Sjodin, P.A. 登録日 2015-07-02 公開日 2015-09-09 最終更新日 2024-03-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor. Acs Med.Chem.Lett., 7, 2016
5ARG	SMYD2 in complex with SGC probe BAY-598 分子名称: GLYCEROL, N-LYSINE METHYLTRANSFERASE SMYD2, N-[1-(N'-CYANO-N-[3-(DIFLUOROMETHOXY)PHENYL]CARBAMIMIDOYL)-3-(3,4-DICHLOROPHENYL)-4,5-DIHYDRO-1H-PYRAZOL-4-YL]-N-ETHYL-2-HYDROXYACETAMIDE, ... 著者 Hillig, R.C, Badock, V, Barak, N, Stellfeld, T, Eggert, E, ter Laak, A, Weiske, J, Christ, C.D, Koehr, S, Stoeckigt, D, Mowat, J, Mueller, T, Fernandez-Montalvan, A.E, Hartung, I.V, Stresemann, C, Brumby, T, Weinmann, H. 登録日 2015-09-24 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.99 Å) 主引用文献 Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2. J.Med.Chem., 59, 2016
5ARF	SMYD2 in complex with small molecule inhibitor compound-2 分子名称: N-LYSINE METHYLTRANSFERASE SMYD2, N-[3-(4-CHLOROPHENYL)-1-{N'-CYANO-N-[3-(DIFLUOROMETHOXY)PHENYL]CARBAMIMIDOYL}-4,5-DIHYDRO-1H- PYRAZOL-4-YL]-N-ETHYL-2-HYDROXYACETAMIDE, S-ADENOSYLMETHIONINE, ... 著者 Hillig, R.C, Badock, V, Barak, N, Stellfeld, T, Eggert, E, ter Laak, A, Weiske, J, Christ, C.D, Koehr, S, Stoeckigt, D, Mowat, J, Mueller, T, Fernandez-Montalvan, A.E, Hartung, I.V, Stresemann, C, Brumby, T, Weinmann, H. 登録日 2015-09-24 公開日 2016-04-27 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (Bay-598) for the Protein Lysine Methyltransferase Smyd2. J.Med.Chem., 59, 2016
5EX0	Crystal structure of human SMYD3 in complex with a MAP3K2 peptide 分子名称: ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, MAP3K2 peptide, ... 著者 Fu, W, Liu, N, Qiao, Q, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. 登録日 2015-11-23 公開日 2016-03-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
5EX3	Crystal structure of human SMYD3 in complex with a VEGFR1 peptide 分子名称: ACETIC ACID, Histone-lysine N-methyltransferase SMYD3, S-ADENOSYL-L-HOMOCYSTEINE, ... 著者 Qiao, Q, Fu, W, Liu, N, Wang, M, Min, J, Zhu, B, Xu, R.M, Yang, N. 登録日 2015-11-23 公開日 2016-03-09 最終更新日 2017-10-18 実験手法 X-RAY DIFFRACTION (2.408 Å) 主引用文献 Structural Basis for Substrate Preference of SMYD3, a SET Domain-containing Protein Lysine Methyltransferase J.Biol.Chem., 291, 2016
3PDN	Crystal structure of SmyD3 in complex with methyltransferase inhibitor sinefungin 分子名称: GLYCEROL, MAGNESIUM ION, SET and MYND domain-containing protein 3, ... 著者 Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2010-10-23 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structural Insights into the Autoinhibition and Posttranslational Activation of Histone Methyltransferase SmyD3. J.Mol.Biol., 406, 2011
3QWW	Crystal structure of histone lysine methyltransferase SmyD2 in complex with the methyltransferase inhibitor sinefungin 分子名称: SET and MYND domain-containing protein 2, SINEFUNGIN, ZINC ION 著者 Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2011-02-28 公開日 2011-07-06 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain. Plos One, 6, 2011
3QWV	Crystal structure of histone lysine methyltransferase SmyD2 in complex with the cofactor product AdoHcy 分子名称: S-ADENOSYL-L-HOMOCYSTEINE, SET and MYND domain-containing protein 2, ZINC ION 著者 Jiang, Y, Sirinupong, N, Brunzelle, J, Yang, Z. 登録日 2011-02-28 公開日 2011-07-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Crystal structures of histone and p53 methyltransferase SmyD2 reveal a conformational flexibility of the autoinhibitory C-terminal domain. Plos One, 6, 2011
3RIB	Human lysine methyltransferase Smyd2 in complex with AdoHcy 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, ... 著者 Xu, S, Zhang, T, Zhong, C, Ding, J. 登録日 2011-04-13 公開日 2011-07-20 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.79 Å) 主引用文献 Structure of human lysine methyltransferase Smyd2 reveals insights into the substrate divergence in Smyd proteins J Mol Cell Biol, 3, 2011
3S7D	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, Monomethylated p53 peptide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2011-09-21 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3S7B	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, N-cyclohexyl-N~3~-[2-(3,4-dichlorophenyl)ethyl]-N-(2-{[2-(5-hydroxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-8-yl)ethyl]amino}ethyl)-beta-alaninamide, N-lysine methyltransferase SMYD2, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3RU0	Cocrystal structure of human SMYD3 with inhibitor Sinefungin bound 分子名称: SET and MYND domain-containing protein 3, SINEFUNGIN, ZINC ION 著者 Foreman, K.W, Brown, M, Park, F, Emtage, S, Harriss, J, Das, C, Zhu, L, Crew, A, Arnold, L, Shaaban, S, Tucker, P. 登録日 2011-05-04 公開日 2011-05-18 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.849 Å) 主引用文献 Structural and Functional Profiling of the Human Histone Methyltransferase SMYD3. Plos One, 6, 2011
3S7F	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: (R,R)-2,3-BUTANEDIOL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3S7J	Structural Basis of Substrate Methylation and Inhibition of SMYD2 分子名称: N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ZINC ION 著者 Ferguson, A.D. 登録日 2011-05-26 公開日 2011-08-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.04 Å) 主引用文献 Structural Basis of Substrate Methylation and Inhibition of SMYD2. Structure, 19, 2011
3TG5	Structure of SMYD2 in complex with p53 and SAH 分子名称: Cellular tumor antigen p53, GLYCEROL, N-lysine methyltransferase SMYD2, ... 著者 Zhao, K, Wang, L. 登録日 2011-08-17 公開日 2011-08-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011
3QWP	Crystal structure of SET and MYND domain containing 3; Zinc finger MYND domain-containing protein 1 分子名称: GLYCEROL, S-ADENOSYLMETHIONINE, SET and MYND domain-containing protein 3, ... 著者 Dong, A, Dombrovski, L, Li, Y, Wernimont, A, Weigelt, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2011-02-28 公開日 2011-04-06 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.53 Å) 主引用文献 The Crystal Structure of human Histone-lysine N-methyltransferase SMYD3 To be Published
3TG4	Structure of SMYD2 in complex with SAM 分子名称: GLYCEROL, N-lysine methyltransferase SMYD2, S-ADENOSYLMETHIONINE, ... 著者 Zhao, K, Wang, L. 登録日 2011-08-17 公開日 2011-08-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of human SMYD2 reveals the basis of p53 tumor suppressor methylation J.Biol.Chem., 2011

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