4ZW2
 
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3JBR
 | | Cryo-EM structure of the rabbit voltage-gated calcium channel Cav1.1 complex at 4.2 angstrom | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Voltage-dependent L-type calcium channel subunit alpha-1S, ... | | 著者 | Wu, J.P, Yan, Z, Yan, N. | | 登録日 | 2015-09-29 | | 公開日 | 2015-12-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structure of the voltage-gated calcium channel Cav1.1 complex
Science, 350, 2015
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5B64
 | | A novel binding mode of MAGUK GK domain revealed by DLG GK domain in complex with KIF13B MBS domain | | 分子名称: | DLG GK, GLYCEROL, Protein Kif13b, ... | | 著者 | Shang, Y, Zhu, J, Zhang, M. | | 登録日 | 2016-05-24 | | 公開日 | 2016-10-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B
Structure, 24, 2016
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5GJW
 | | Structure of the mammalian voltage-gated calcium channel Cav1.1 complex for ClassII map | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, J.P, Yan, Z, Li, Z.Q, Zhou, Q, Yan, N. | | 登録日 | 2016-07-02 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
Nature, 537, 2016
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5GJV
 | | Structure of the mammalian voltage-gated calcium channel Cav1.1 complex at near atomic resolution | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Wu, J.P, Yan, Z, Li, Z.Q, Zhou, Q, Yan, N. | | 登録日 | 2016-07-02 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structure of the voltage-gated calcium channel Cav1.1 at 3.6 angstrom resolution
Nature, 537, 2016
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5GNV
 | | Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain | | 分子名称: | Disks large homolog 4, Microtubule-associated protein 1A, SULFATE ION | | 著者 | Shang, Y, Xia, Y, Zhu, R, Zhu, J. | | 登録日 | 2016-07-25 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.596 Å) | | 主引用文献 | Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain
Biochem. J., 474, 2017
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5V2P
 | | CaV beta2a subunit: CaV1.2 AID-CAP complex | | 分子名称: | 1,3-bis(bromomethyl)benzene, NICKEL (II) ION, PENTAETHYLENE GLYCOL, ... | | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
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5V2Q
 | | CaV beta2a subunit: CaV1.2 AID-CEN complex | | 分子名称: | 1,3-bis(bromomethyl)benzene, CHLORIDE ION, Voltage-dependent L-type calcium channel subunit alpha-1C, ... | | 著者 | Findeisen, F, Campiglio, M, Jo, H, Rumpf, C.H, Pope, L, Flucher, B, Degrado, W.F, Minor, D.L. | | 登録日 | 2017-03-06 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Stapled Voltage-Gated Calcium Channel (CaV) alpha-Interaction Domain (AID) Peptides Act As Selective Protein-Protein Interaction Inhibitors of CaV Function.
ACS Chem Neurosci, 8, 2017
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5YPO
 | | Crystal structure of PSD-95 GK domain in complex with phospho-SAPAP peptide | | 分子名称: | Disks large homolog 4, GLYCEROL, SAPAP | | 著者 | Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhang, R, Zhang, M. | | 登録日 | 2017-11-02 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
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5YPR
 | | Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor | | 分子名称: | Disks large homolog 4, Synthesized GK inhibitor | | 著者 | Zhu, J, Zhou, Q, Shang, Y, Weng, Z, Zhu, R, Zhang, M. | | 登録日 | 2017-11-02 | | 公開日 | 2018-03-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.349 Å) | | 主引用文献 | Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21, 2017
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6MFU
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6NUI
 | | Human Guanylate Kinase | | 分子名称: | Guanylate kinase | | 著者 | Sabo, T.M, Khan, N, Ban, D, Trigo-Mourino, P, Carneiro, M.G, Trent, J.O, Konrad, M, Lee, D. | | 登録日 | 2019-02-01 | | 公開日 | 2019-06-26 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and functional investigation of human guanylate kinase reveals allosteric networking and a crucial role for the enzyme in cancer.
J.Biol.Chem., 294, 2019
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6JP5
 | | Rabbit Cav1.1-Nifedipine Complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-25 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JP8
 | | Rabbit Cav1.1-Bay K8644 Complex | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JPB
 | | Rabbit Cav1.1-Diltiazem Complex | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6JPA
 | | Rabbit Cav1.1-Verapamil Complex | | 分子名称: | (2S)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Zhao, Y, Huang, G, Wu, J, Yan, N. | | 登録日 | 2019-03-26 | | 公開日 | 2019-06-12 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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6WCT
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7LUY
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7M4R
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7MIX
 | | Human N-type voltage-gated calcium channel Cav2.2 in the presence of ziconotide at 3.0 Angstrom resolution | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Gao, S, Yao, X. | | 登録日 | 2021-04-18 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-18 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
Nature, 596, 2021
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7MIY
 | | Human N-type voltage-gated calcium channel Cav2.2 at 3.1 Angstrom resolution | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Gao, S, Yao, X. | | 登録日 | 2021-04-18 | | 公開日 | 2021-07-07 | | 最終更新日 | 2021-08-18 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structure of human Ca v 2.2 channel blocked by the painkiller ziconotide.
Nature, 596, 2021
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7N6G
 | | C1 of central pair | | 分子名称: | CPC1, Calmodulin, DPY30, ... | | 著者 | Han, L, Zhang, K. | | 登録日 | 2021-06-08 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM structure of an active central apparatus.
Nat.Struct.Mol.Biol., 29, 2022
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7F7G
 | | a linear Peptide Inhibitors in complex with GK domain | | 分子名称: | DLG4 GK domain, UNK-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYS-ALA-ILE-GLN-UNK | | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-02-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.446 Å) | | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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7F7I
 | | Stapled Peptide Inhibitor in complex with PSD95 GK domain | | 分子名称: | ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4 | | 著者 | Shang, Y, Huang, X, Li, X, Zhang, M. | | 登録日 | 2021-06-29 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.595 Å) | | 主引用文献 | Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
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7S5E
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