5YPR

Crystal Structure of PSD-95 SH3-GK domain in complex with a synthesized inhibitor

Summary for 5YPR

Related5YPO
DescriptorDisks large homolog 4, Synthesized GK inhibitor (3 entities in total)
Functional Keywordsgk maguk inhibitor designed peptide, protein binding
Biological sourceRattus norvegicus (Rat)
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Cellular locationCell membrane ; Lipid-anchor ; Cytoplasmic side  P31016
Total number of polymer chains2
Total molecular weight38891.54
Authors
Zhu, J.,Zhou, Q.,Shang, Y.,Weng, Z.,Zhu, R.,Zhang, M. (deposition date: 2017-11-02, release date: 2018-03-14)
Primary citation
Zhu, J.,Zhou, Q.,Shang, Y.,Li, H.,Peng, M.,Ke, X.,Weng, Z.,Zhang, R.,Huang, X.,Li, S.S.C.,Feng, G.,Lu, Y.,Zhang, M.
Synaptic Targeting and Function of SAPAPs Mediated by Phosphorylation-Dependent Binding to PSD-95 MAGUKs.
Cell Rep, 21:3781-3793, 2017
PubMed: 29281827 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2017.11.107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.349 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2644009.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution