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7QID
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tentative model of the human insulin receptor ectodomain bound by three insulin
分子名称: Insulin, Insulin receptor, Isoform Short of Insulin receptor
著者Gutman, T, Schaefer, I.B, Poojari, C.S, Vattulainen, I, Strauss, M, Coskun, U.
登録日2021-12-14
公開日2022-02-02
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Cryo-EM structure of the complete and ligand-saturated insulin receptor ectodomain
J Cell Biol, 219, 2020
7PG2
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BU of 7pg2 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin, conf 1
分子名称: Insulin, Isoform Short of Insulin receptor
著者Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
登録日2021-08-12
公開日2022-02-02
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (6.7 Å)
主引用文献Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG4
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BU of 7pg4 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 2 insulin, conf 3
分子名称: Insulin, Isoform Short of Insulin receptor
著者Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
登録日2021-08-12
公開日2022-02-02
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (9.1 Å)
主引用文献Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG3
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BU of 7pg3 by Molmil
Low resolution Cryo-EM structure of the full-length insulin receptor bound to 3 insulin, conf 2
分子名称: Insulin, Isoform Short of Insulin receptor
著者Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
登録日2021-08-12
公開日2022-02-02
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (7.3 Å)
主引用文献Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7PG0
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BU of 7pg0 by Molmil
Low resolution Cryo-EM structure of full-length insulin receptor bound to 3 insulin with visible ddm micelle, conf 1
分子名称: Insulin, Isoform Short of Insulin receptor
著者Nielsen, J.A, Slaaby, R, Boesen, T, Hummelshoj, T, Brandt, J, Schluckebier, G, Nissen, P.
登録日2021-08-12
公開日2022-02-02
最終更新日2022-02-16
実験手法ELECTRON MICROSCOPY (7.6 Å)
主引用文献Structural Investigations of Full-Length Insulin Receptor Dynamics and Signalling.
J.Mol.Biol., 434, 2022
7JP3
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BU of 7jp3 by Molmil
Des-B29,B30-insulin
分子名称: CHLORIDE ION, Insulin B chain,Insulin A chain, PHENOL, ...
著者Yoder, J, Weiss, M.A, DiMarchi, R, Zaykov, A.
登録日2020-08-07
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Des-B29,B30-insulin
To Be Published
7S4Y
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BU of 7s4y by Molmil
Serial Macromolecular Crystallography at ALBA Synchrotron Light Source - Insulin
分子名称: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
著者Martin-Garcia, J.M, Botha, S, Hu, H, Jernigan, R, Castellvi, A, Lisova, S, Gil, F, Calisto, B, Crespo, I, Roy-Chowdbury, S, Grieco, A, Ketawala, G, Weierstall, U, Spence, J, Fromme, P, Zatsepin, N, Boer, R, Carpena, X.
登録日2021-09-09
公開日2021-10-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Serial macromolecular crystallography at ALBA Synchrotron Light Source.
J.Synchrotron Radiat., 29, 2022
7KD6
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BU of 7kd6 by Molmil
Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Lawrence, M.C, Menting, J.G.
登録日2020-10-08
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Single-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Biophys.J., 2022
7AC4
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BU of 7ac4 by Molmil
Structure of insulin collected by rotation serial crystallography on a COC membrane at a synchrotron source
分子名称: Insulin, R-1,2-PROPANEDIOL, SODIUM ION
著者Martiel, I, Padeste, C, Karpik, A, Huang, C.Y, Vera, L, Wang, M, Marsh, M.
登録日2020-09-09
公開日2021-09-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.46 Å)
主引用文献Versatile microporous polymer-based supports for serial macromolecular crystallography.
Acta Crystallogr D Struct Biol, 77, 2021
7NHU
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BU of 7nhu by Molmil
Crystal structure of desB30 insulin produced by cell free protein synthesis
分子名称: Insulin
著者Johansson, E.
登録日2021-02-11
公開日2021-06-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Cell free protein synthesis versus yeast expression - A comparison using insulin as a model protein.
Protein Expr.Purif., 186, 2021
7ELJ
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BU of 7elj by Molmil
Prion Derived Tetrapeptide Stabilizes Thermolabile Insulin via Conformational Trapping
分子名称: IS1, Insulin A Chain, Insulin B chain
著者Banerjee, N.
登録日2021-04-11
公開日2021-04-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Prion-derived tetrapeptide stabilizes thermolabile insulin via conformational trapping.
Iscience, 24, 2021
7BW8
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BU of 7bw8 by Molmil
Cryo-EM Structure for the Insulin Binding Region in the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin
分子名称: Insulin fusion, Insulin receptor
著者Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
登録日2020-04-14
公開日2021-04-14
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
7BWA
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BU of 7bwa by Molmil
Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 2 Insulin
分子名称: Insulin fusion, Insulin receptor
著者Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
登録日2020-04-14
公開日2021-04-14
実験手法ELECTRON MICROSCOPY (4.9 Å)
主引用文献Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
7BW7
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BU of 7bw7 by Molmil
Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex with 1 Insulin.
分子名称: Insulin fusion, Insulin receptor
著者Yu, D, Zhang, X, Sun, J, Li, X, Wu, Z, Han, X, Fan, C, Ma, Y, Ouyang, Q, Wang, T.
登録日2020-04-13
公開日2021-04-14
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Insulin Binding Induced the Ectodomain Conformational Dynamics in the Full-length Human Insulin Receptor
To Be Published
6ZHB
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BU of 6zhb by Molmil
3D electron diffraction structure of bovine insulin
分子名称: Insulin, ZINC ION
著者Blum, T, Housset, D, Clabbers, M.T.B, van Genderen, E, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G, Ling, W.L, Abrahams, J.P.
登録日2020-06-22
公開日2021-01-27
最終更新日2024-01-24
実験手法ELECTRON CRYSTALLOGRAPHY (3.25 Å)
主引用文献Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
Acta Crystallogr D Struct Biol, 77, 2021
6ZI8
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BU of 6zi8 by Molmil
X-ray diffraction structure of bovine insulin at 2.3 A resolution
分子名称: CHLORIDE ION, Insulin, ZINC ION
著者Housset, D, Ling, W.L, Bacia-Verloop, M, Zander, U, McCarthy, A.A, Schoehn, G.
登録日2020-06-25
公開日2021-01-20
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
Acta Crystallogr D Struct Biol, 77, 2021
6Z7Y
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BU of 6z7y by Molmil
Human insulin in complex with the analytical antibody OXI-005 Fab
分子名称: Insulin, OXI-005 Fab Heavy chain, OXI-005 Fab Light chain
著者Johansson, E.
登録日2020-06-02
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
6Z7Z
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BU of 6z7z by Molmil
Porcine insulin in complex with the analytical antibody OXI-005 Fab
分子名称: Insulin, MAGNESIUM ION, OXI-005 Fab Heavy chain, ...
著者Johansson, E.
登録日2020-06-02
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
6Z7W
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BU of 6z7w by Molmil
Human insulin in complex with the analytical antibody HUI-018 Fab
分子名称: HUI-018 Fab Heavy Chain, Insulin, MAb 6H10 light chain
著者Johansson, E.
登録日2020-06-02
公開日2020-12-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Insulin binding to the analytical antibody sandwich pair OXI-005 and HUI-018: Epitope mapping and binding properties.
Protein Sci., 30, 2021
6TC2
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BU of 6tc2 by Molmil
Monoclinic human insulin in complex with p-coumaric acid
分子名称: 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ...
著者Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I.
登録日2019-11-04
公開日2020-11-11
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.
Acta Crystallogr D Struct Biol, 76, 2020
6KH8
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BU of 6kh8 by Molmil
Solution structure of Zn free Bovine Pancreatic Insulin in 20% acetic acid-d4 (pH 1.9)
分子名称: Insulin A Chain, Insulin B chain
著者Bhunia, A, Ratha, B.N, Kar, R.K, Brender, J.R.
登録日2019-07-14
公開日2020-10-07
最終更新日2020-11-18
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
6U46
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BU of 6u46 by Molmil
Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
分子名称: Insulin
著者Yang, Y, Weiss, M.A.
登録日2019-08-23
公開日2020-08-26
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Solution Structure of a Heat-Resistant Long-Acting Insulin Analog
To Be Published
6KH9
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BU of 6kh9 by Molmil
Solution structure of bovine insulin amyloid intermediate-1
分子名称: Insulin A chain, Insulin B chain
著者Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A.
登録日2019-07-14
公開日2020-08-12
最終更新日2020-11-18
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
6KHA
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BU of 6kha by Molmil
Solution structure of bovine insulin amyloid intermediate-2
分子名称: Insulin A chain, Insulin B chain
著者Ratha, B.N, Kar, R.K, Brender, J.B, Bhunia, A.
登録日2019-07-14
公開日2020-08-12
最終更新日2020-11-18
実験手法SOLUTION NMR
主引用文献High-resolution structure of a partially folded insulin aggregation intermediate.
Proteins, 88, 2020
6X4X
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BU of 6x4x by Molmil
B24Y DKP insulin
分子名称: Insulin, Insulin chain A
著者Weiss, M.A, Yang, Y.
登録日2020-05-24
公開日2020-08-05
最終更新日2023-06-14
実験手法SOLUTION NMR
主引用文献Evolution of insulin at the edge of foldability and its medical implications.
Proc.Natl.Acad.Sci.USA, 117, 2020

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件を2024-06-12に公開中

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