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3F23
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BU of 3f23 by Molmil
Crystal structure of Zalpha in complex with d(CGGCCG)
分子名称: DNA (5'-D(*DTP*DCP*DGP*DGP*DCP*DCP*DG)-3'), Double-stranded RNA-specific adenosine deaminase
著者Ha, S.C, Choi, J, Kim, K.K.
登録日2008-10-28
公開日2008-12-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1
Nucleic Acids Res., 37, 2009
3FAU
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BU of 3fau by Molmil
Crystal Structure of human small-MutS related domain
分子名称: NEDD4-binding protein 2
著者Kim, T.G, Kwon, T.H, Ryu, E.K, Min, K, Heo, S.-D, Song, K.M, Jun, W.J, Jung, E.
登録日2008-11-18
公開日2009-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Strcutral Dynamincs of the Endonuclease Small-MutS Related Domains of BCL3 binding protein
To be Published
3FB2
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BU of 3fb2 by Molmil
Crystal structure of the human brain alpha spectrin repeats 15 and 16. Northeast Structural Genomics Consortium target HR5563a.
分子名称: Spectrin alpha chain, brain spectrin
著者Vorobiev, S.M, Su, M, Seetharaman, J, Shastry, R, Foote, E.L, Ciccosanti, C, Janjua, H, Xiao, R, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
登録日2008-11-18
公開日2008-11-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the human brain alpha spectrin repeats 15 and 16.
To be Published
3FJB
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BU of 3fjb by Molmil
Crystal structure of V31I mutant of Human acidic fibroblast growth factor
分子名称: Heparin-binding growth factor 1, SULFATE ION
著者Blaber, M, Lee, J.
登録日2008-12-14
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The interaction between thermodynamic stability and buried free cysteines in regulating the functional half-life of fibroblast growth factor-1.
J.Mol.Biol., 393, 2009
3FCB
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BU of 3fcb by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH
分子名称: N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINE, transthyretin
著者Gales, L, Damas, A.M.
登録日2008-11-21
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
3FJI
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BU of 3fji by Molmil
Crystal structure of K12V/C83I/C117V mutant of Human acidic fibroblast growth factor
分子名称: Heparin-binding growth factor 1, SULFATE ION
著者Blaber, M, Lee, J.
登録日2008-12-14
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural basis of conserved cysteine in the fibroblast growth factor family: evidence for a vestigial half-cystine.
J.Mol.Biol., 393, 2009
3FCO
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BU of 3fco by Molmil
Crystal Structure of 11beta-Hydroxysteroid Dehydrogenase 1 (11b-HSD1) in Complex with Benzamide Inhibitor
分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, N-cyclopropyl-N-(cis-4-cyclopropyl-4-hydroxycyclohexyl)-4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]benzamide, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Wang, Z, Sudom, A, Walker, N.P.
登録日2008-11-21
公開日2009-12-01
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Optimization of novel di-substituted cyclohexylbenzamide derivatives as potent 11 beta-HSD1 inhibitors.
Bioorg.Med.Chem.Lett., 19, 2009
3FKI
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BU of 3fki by Molmil
12-Subunit RNA Polymerase II Refined with Zn-SAD data
分子名称: DNA-directed RNA polymerase II subunit RPB1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB2, ...
著者Meyer, P.A, Ye, P, Suh, M.H, Zhang, M, Fu, J.
登録日2008-12-16
公開日2009-03-10
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.88 Å)
主引用文献Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data
J.Biol.Chem., 284, 2009
3FFN
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BU of 3ffn by Molmil
Crystal structure of calcium-free human gelsolin
分子名称: Gelsolin
著者Chumnarnsilpa, S, Robinson, R.C, Burtnick, L.D.
登録日2008-12-04
公開日2009-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F9C
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BU of 3f9c by Molmil
Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by diisopropylfluorophosphate
分子名称: DIISOPROPYL PHOSPHONATE, Platelet-activating factor acetylhydrolase
著者Samanta, U, Bahnson, B.J.
登録日2008-11-13
公開日2009-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structures of human group-VIIA phospholipase A2 inhibited by organophosphorus nerve agents exhibit non-aged complexes.
Biochem Pharmacol, 78, 2009
3F5U
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BU of 3f5u by Molmil
Crystal structure of the death associated protein kinase in complex with AMPPNP and Mg2+
分子名称: Death-associated protein kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
著者McNamara, L.K, Watterson, D.M, Brunzelle, J.S.
登録日2008-11-04
公開日2009-03-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural insight into nucleotide recognition by human death-associated protein kinase.
Acta Crystallogr.,Sect.D, 65, 2009
3FI4
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BU of 3fi4 by Molmil
P38 kinase crystal structure in complex with RO4499
分子名称: (2S)-1-{[3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}propan-2-ol, Mitogen-activated protein kinase 14
著者Kuglstatter, A, Knapp, M, Dunten, P.
登録日2008-12-10
公開日2009-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity
To be Published
3FJ6
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BU of 3fj6 by Molmil
Human dihydroorotate dehydrogenase in complex with a leflunomide derivative inhibitor 2
分子名称: (2Z)-2-cyano-N-(2,2'-dichlorobiphenyl-4-yl)-3-hydroxybut-2-enamide, ACETATE ION, Dihydroorotate dehydrogenase, ...
著者Heikkila, T.
登録日2008-12-14
公開日2009-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases
J.Med.Chem., 52, 2009
3FC8
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BU of 3fc8 by Molmil
Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOMe
分子名称: METHYL N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINATE, transthyretin
著者Gales, L, Damas, A.M.
登録日2008-11-21
公開日2009-02-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4, 2009
3FQ4
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BU of 3fq4 by Molmil
Crystal structure of the Calx-beta domain of integrin beta4
分子名称: Integrin beta-4
著者Alonso-Garcia, N, Ingles-Prieto, A, de Pereda, J.M.
登録日2009-01-07
公開日2009-06-23
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.487 Å)
主引用文献Structure of the Calx-beta domain of the integrin beta4 subunit: insights into function and cation-independent stability
Acta Crystallogr.,Sect.D, 65, 2009
3FCX
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BU of 3fcx by Molmil
Crystal structure of human esterase D
分子名称: CALCIUM ION, MAGNESIUM ION, S-formylglutathione hydrolase
著者Wu, D, Li, Y, Song, G, Zhang, D, Shaw, N, Liu, Z.J.
登録日2008-11-24
公開日2008-12-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of human esterase D: a potential genetic marker of retinoblastoma
Faseb J., 23, 2009
3F1N
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BU of 3f1n by Molmil
Crystal structure of a high affinity heterodimer of HIF2 alpha and ARNT C-terminal PAS domains, with internally bound ethylene glycol.
分子名称: 1,2-ETHANEDIOL, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
著者Scheuermann, T.H, Tomchick, D.R, Machius, M, Guo, Y, Bruick, R.K, Gardner, K.H.
登録日2008-10-28
公開日2009-01-20
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.479 Å)
主引用文献Artificial ligand binding within the HIF2alpha PAS-B domain of the HIF2 transcription factor.
Proc.Natl.Acad.Sci.USA, 106, 2009
3F22
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BU of 3f22 by Molmil
Crystal structure of Zalpha in complex with d(CGTACG)
分子名称: DNA (5'-D(*DTP*DCP*DGP*DTP*DAP*DCP*DG)-3'), Double-stranded RNA-specific adenosine deaminase
著者Ha, S.C, Choi, J, Kim, K.K.
登録日2008-10-28
公開日2008-12-30
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The structures of non-CG-repeat Z-DNAs co-crystallized with the Z-DNA-binding domain, hZ{alpha}ADAR1
Nucleic Acids Res., 37, 2009
3F2A
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BU of 3f2a by Molmil
Crystal structure of human Pim-1 in complex with DAPPA
分子名称: (2E)-3-{3-[6-(4-methyl-1,4-diazepan-1-yl)pyrazin-2-yl]phenyl}prop-2-enoic acid, MAGNESIUM ION, Proto-oncogene serine/threonine-protein kinase Pim-1
著者Qian, K.
登録日2008-10-29
公開日2009-03-10
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.
J.Med.Chem., 52, 2009
3D1V
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BU of 3d1v by Molmil
Crystal structure of human PNP complexed with 2-mercapto(3H) quinazolinone
分子名称: 2-mercapto(3H)quinazolinone, Purine nucleoside phosphorylase, SULFATE ION
著者De Azevedo Jr, W.F, Basso, L.A, Santos, D.S.
登録日2008-05-06
公開日2009-07-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural studies of human purine nucleoside phosphorylase: towards a new specific empirical scoring function
Arch.Biochem.Biophys., 479, 2008
3D5R
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BU of 3d5r by Molmil
Crystal Structure of Efb-C (N138A) / C3d Complex
分子名称: Complement C3, Fibrinogen-binding protein
著者Geisbrecht, B.V.
登録日2008-05-16
公開日2008-09-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Electrostatic contributions drive the interaction between Staphylococcus aureus protein Efb-C and its complement target C3d.
Protein Sci., 17, 2008
3CFM
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BU of 3cfm by Molmil
Crystal structure of the apo form of human wild-type transthyretin
分子名称: Transthyretin
著者Lima, L.-M.T.R, Foguel, D, Polikarpov, I.
登録日2008-03-04
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Identification of a novel ligand binding motif in the transthyretin channel.
Bioorg.Med.Chem., 18, 2010
3CJK
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BU of 3cjk by Molmil
Crystal structure of the adduct HAH1-Cd(II)-MNK1.
分子名称: CADMIUM ION, Copper transport protein ATOX1, Copper-transporting ATPase 1
著者Banci, L, Bertini, I, Calderone, V, Felli, I, Della-Malva, N, Pavelkova, A, Rosato, A.
登録日2008-03-13
公開日2008-12-30
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.
Biochem.J., 422, 2009
3CNK
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BU of 3cnk by Molmil
Crystal Structure of the dimerization domain of human filamin A
分子名称: Filamin-A, SULFATE ION
著者Lee, B.J, Seo, M.D, Seok, S.H, Lee, S.J, Kwon, A.R, Im, H.
登録日2008-03-26
公開日2009-02-10
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Crystal structure of the dimerization domain of human filamin A
Proteins, 75, 2008
3CP9
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Crystal structure of the VEGFR2 kinase domain in complex with a pyridone inhibitor
分子名称: 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one, Vascular endothelial growth factor receptor 2
著者Whittington, D.A, Long, A.M, Rose, P, Gu, Y, Zhao, H.
登録日2008-03-31
公開日2008-06-17
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Discovery of Aryl Aminoquinazoline Pyridones as Potent, Selective, and Orally Efficacious Inhibitors of Receptor Tyrosine Kinase c-Kit.
J.Med.Chem., 51, 2008

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