3FI4

P38 kinase crystal structure in complex with RO4499

Summary for 3FI4

• Entry DOI: 10.2210/pdb3fi4/pdb
• Descriptor: Mitogen-activated protein kinase 14, (2S)-1-{[3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}propan-2-ol (3 entities in total)
• Functional Keywords: p38; map kinase; serine/threonine kinase, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase, signaling protein
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm (By similarity): Q16539
• Total number of polymer chains: 1
• Total formula weight: 43152.53

Authors

Kuglstatter, A.,Knapp, M.,Dunten, P. (deposition date: 2008-12-10, release date: 2009-12-22, Last modification date: 2023-09-06)

• Primary citation: Arora, N.,Williams, C.,Delano, W.,Will, D.,Kuglstatter, A.; Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)