3FI4
P38 kinase crystal structure in complex with RO4499
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Mitogen-activated protein kinase 14 | polymer | 372 | 42720.7 | 1 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (human) | Mitogen-activated protein kinase p38 alpha, MAP kinase p38 alpha, Cytokine suppressive anti-inflammatory drug-binding protein, CSAID-binding protein, CSBP, MAX-interacting protein 2, MAP kinase MXI2, SAPK2A |
2 | A | (2S)-1-{[3-(2-chlorophenyl)-6-(2,4-difluorophenoxy)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]amino}propan-2-ol | non-polymer | 431.8 | 1 | Chemie (FI4) | |||
3 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Met -11 | - | expression tag |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Lys 57 | Arg 57 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 42720.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 431.8 | |
All* | Total formula weight | 43152.5 |