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3FCB

Crystal structure of transthyretin in complex with iododiflunisal-betaAlaOH

Summary for 3FCB
Entry DOI10.2210/pdb3fcb/pdb
Related3FC8
Descriptortransthyretin, N-[(2',4'-DIFLUORO-4-HYDROXY-5-IODOBIPHENYL-3-YL)CARBONYL]-BETA-ALANINE (3 entities in total)
Functional Keywordstransthyretin, amyloid, inhibitors, iodine, polymorphism, polyneuropathy, retinol-binding, secreted, hormone binding protein
Biological sourceHomo sapiens (human)
Cellular locationSecreted: P02766
Total number of polymer chains2
Total formula weight27738.25
Authors
Gales, L.,Damas, A.M. (deposition date: 2008-11-21, release date: 2009-02-17, Last modification date: 2023-09-06)
Primary citationMairal, T.,Nieto, J.,Pinto, M.,Almeida, M.R.,Gales, L.,Ballesteros, A.,Barluenga, J.,Perez, J.J.,Vazquez, J.T.,Centeno, N.B.,Saraiva, M.J.,Damas, A.M.,Planas, A.,Arsequell, G.,Valencia, G.
Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.
Plos One, 4:e4124-e4124, 2009
Cited by
PubMed: 19125186
DOI: 10.1371/journal.pone.0004124
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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