PDB: 13480 件ウェブページステータス検索Chemie searchBIRD

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6LD3	Zika NS5 polymerase domain 分子名称: 2,4-dimethoxy-5-thiophen-2-yl-benzoic acid, RNA-directed RNA polymerase NS5, ZINC ION, ... 著者 El Sahili, A, Lescar, J. 登録日 2019-11-20 公開日 2020-08-19 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Non-nucleoside Inhibitors of Zika Virus RNA-Dependent RNA Polymerase. J.Virol., 94, 2020
6S2L	FMDV 3D polymerase crystallized in presence of (F)uridylylated VPg peptide 分子名称: GLYCEROL, Genome polyprotein 著者 Verdaguer, N, Ferrer-Orta, C. 登録日 2019-06-21 公開日 2019-07-03 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 (F)uridylylated Peptides Linked to VPg1 of Foot-and- Mouth Disease Virus (FMDV): Design, Synthesis and X-Ray Crystallography of the Complexes with FMDV RNA-Dependent RNA Polymerase. Molecules, 24, 2019
8AC2	RNA polymerase- post-terminated, open clamp state 分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-05 公開日 2022-10-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
5JNB	structure of GLD-2/RNP-8 complex 分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... 著者 Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. 登録日 2016-04-29 公開日 2016-06-22 最終更新日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.486 Å) 主引用文献 Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. Rna, 22, 2016
6KWQ	Crystal structure of enterovirus 71 polymerase elongation complex (native form) 分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, MAGNESIUM ION, ... 著者 Shi, W, Gong, P. 登録日 2019-09-08 公開日 2019-12-11 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.76 Å) 主引用文献 A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability. Nucleic Acids Res., 48, 2020
8EXY	M. tuberculosis RNAP paused complex with B. subtilis NusG and GMPCPP 分子名称: DNA (38-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-26 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOS	M. tuberculosis RNAP elongation complex with NusG and CMPCPP 分子名称: 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, DNA (36-MER), DNA (38-MER), ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-04 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOT	M. tuberculosis RNAP elongation complex with NusG 分子名称: DNA (31-MER), DNA (33-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Vishwakarma, R.K, Murakami, K.S. 登録日 2022-10-04 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
8EOF	Mycobacterium tuberculosis transcription elongation complex with Bacillus subtilis NusG (EC_PG) 分子名称: DNA (35-MER), DNA (38-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Vishwakarm, R.K, Murakami, K.S. 登録日 2022-10-03 公開日 2023-02-01 最終更新日 2024-06-19 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Allosteric mechanism of transcription inhibition by NusG-dependent pausing of RNA polymerase. Proc.Natl.Acad.Sci.USA, 120, 2023
4ROD	Human TFIIB-related factor 2 (Brf2) and TBP bound to TRNAU1 promoter 分子名称: Non-template strand, TATA-box-binding protein, Template strand, ... 著者 Vannini, A, Gouge, J, Satia, K, Guthertz, N. 登録日 2014-10-28 公開日 2015-12-30 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Redox Signaling by the RNA Polymerase III TFIIB-Related Factor Brf2. Cell(Cambridge,Mass.), 163, 2015
7SZK	Cryo-EM structure of 27a bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: (2S,7R,7aR,13aP,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-5,21,23-trihydroxy-27-methoxy-2,4,16,20,22,24,26-heptamethyl-10-[4-(2-methylpropyl)piperazin-1-yl]-12-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1,6,15-trioxo-1,2,7,7a-tetrahydro-6H-2,7-(epoxypentadeca[1,11,13]trienoimino)[1]benzofuro[4,5-a]phenoxazin-25-yl acetate, DNA (5'-D(P*CP*TP*CP*GP*TP*AP*GP*AP*GP*TP*CP*CP*GP*TP*GP*TP*CP*A)-3'), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (2.94 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7SZJ	Cryo-EM structure of Rifamycin bound to E. coli RNAP and rrnBP1 promoter complex 分子名称: DNA (49-MER), DNA (57-MER), DNA-directed RNA polymerase subunit alpha, ... 著者 Shin, Y, Murakami, K.S. 登録日 2021-11-28 公開日 2022-07-13 最終更新日 2024-02-28 実験手法 ELECTRON MICROSCOPY (3.11 Å) 主引用文献 Optimization of Benzoxazinorifamycins to Improve Mycobacterium tuberculosis RNA Polymerase Inhibition and Treatment of Tuberculosis. Acs Infect Dis., 8, 2022
7UWH	CryoEM Structure of E. coli Transcription-Coupled Ribonucleotide Excision Repair (TC-RER) complex bound to ribonucleotide substrate 分子名称: DNA (59-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Hao, Z.T, Grower, M, Bharati, B, Proshkin, S, Epshtein, V, Svetlov, V, Nudler, E, Shamovsky, I. 登録日 2022-05-03 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 RNA polymerase drives ribonucleotide excision DNA repair in E. coli. Cell, 186, 2023
7UWE	CryoEM Structure of E. coli Transcription-Coupled Ribonucleotide Excision Repair (TC-RER) complex 分子名称: DNA (29-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... 著者 Hao, Z.T, Grower, M, Bharati, B, Proshkin, S, Epshtein, V, Svetlov, V, Nudler, E, Shamovsky, I. 登録日 2022-05-03 公開日 2023-05-31 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 RNA polymerase drives ribonucleotide excision DNA repair in E. coli. Cell, 186, 2023
6IZZ	The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678 分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.97 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
6J00	The RNA-dependent RNA polymerase domain of dengue 3 NS5 分子名称: Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.14 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
6IZX	The RNA-dependent RNA polymerase domain of dengue 2 NS5, bound with RK-0404678 分子名称: 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, COBALT (II) ION, Genome polyprotein, ... 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.43 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
8HSR	Thermus thermophilus Rho-engaged RNAP elongation complex (composite structure) 分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA (31-MER), ... 著者 Murayama, Y, Ehara, H, Sekine, S. 登録日 2022-12-20 公開日 2023-05-03 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus. Sci Adv, 9, 2023
6IZY	The RNA-dependent RNA polymerase domain of dengue 2 NS5 分子名称: COBALT (II) ION, Genome polyprotein, ZINC ION 著者 Shimizu, H, Sekine, S. 登録日 2018-12-20 公開日 2019-12-25 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.11 Å) 主引用文献 Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13, 2019
7Z0O	Structure of transcription factor UAF in complex with TBP and 35S rRNA promoter DNA 分子名称: Histone H3, Histone H4, Non-template DNA, ... 著者 Baudin, F, Murciano, B, Fung, H.K.H, Fromm, S.A, Mueller, C.W. 登録日 2022-02-23 公開日 2022-04-27 最終更新日 2024-07-17 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Mechanism of RNA polymerase I selection by transcription factor UAF. Sci Adv, 8, 2022
6C05	Mycobacterium tuberculosis RNAP Holo/RbpA in relaxed state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Darst, S.A, Campbell, E.A, Boyaci Selcuk, H, Chen, J, Lilic, M. 登録日 2017-12-27 公開日 2018-03-28 最終更新日 2019-12-18 実験手法 ELECTRON MICROSCOPY (5.15 Å) 主引用文献 Fidaxomicin jamsMycobacterium tuberculosisRNA polymerase motions needed for initiation via RbpA contacts. Elife, 7, 2018
8POH	Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R) 分子名称: 51-mer vRNA loop (v51_mut_S), MAGNESIUM ION, Polymerase acidic protein, ... 著者 Arragain, B, Cusack, S. 登録日 2023-07-04 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The host RNA polymerase II C-terminal domain is the anchor for replication of the influenza virus genome. Nat Commun, 15, 2024
8ABY	RNA polymerase bound to purified in vitro transcribed regulatory RNA putL - pause prone, closed clamp state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-05 公開日 2022-10-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
8AC0	RNA polymerase at U-rich pause bound to regulatory RNA putL - active, closed clamp state 分子名称: DNA Non-template strand, DNA Template strand, DNA-directed RNA polymerase subunit alpha, ... 著者 Weixlbaumer, A, Dey, S. 登録日 2022-07-05 公開日 2022-10-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022
8ACP	RNA polymerase at U-rich pause bound to regulatory RNA putL - inactive, open clamp state 分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... 著者 Dey, S, Weixlbaumer, A. 登録日 2022-07-06 公開日 2022-10-19 最終更新日 2024-07-24 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Structural insights into RNA-mediated transcription regulation in bacteria. Mol.Cell, 82, 2022

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