PDB: 12060 件ウェブページステータス検索Chemie searchBIRD

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3W29	The high-resolution crystal structure of TsXylA, intracellular xylanase from /Thermoanaerobacterium saccharolyticum JW/SL-YS485/: the complex of the E251A mutant with xylotetraose 分子名称: Glycoside hydrolase family 10, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-alpha-D-xylopyranose 著者 Han, X, Gao, J, Shang, N, Huang, C.-H, Ko, T.-P, Zhu, Z, Wiegel, J, Shao, W, Guo, R.-T. 登録日 2012-11-27 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.39 Å) 主引用文献 Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485 Proteins, 81, 2013
2LU6	NMR solution structure of Midi peptide designed based on m-conotoxins 分子名称: Midi peptide designed based on m-conotoxins 著者 Dyubankova, N, Lescrinier, E, Stevens, M, Tytgat, J, Herdewijn, P, Peigneur, S. 登録日 2012-06-08 公開日 2012-06-27 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Design of bioactive peptides from naturally occurring mu-conotoxin structures. J.Biol.Chem., 287, 2012
5ACC	A Novel Oral Selective Estrogen Receptor Down-regulator, AZD9496, drives Tumour Growth Inhibition in Estrogen Receptor positive and ESR1 Mutant Models 分子名称: (E)-3-(3,5-DIFLUORO-4-((1R,3R)-2-(2-FLUORO-2- METHYLPROPYL)-3-METHYL-2,3,4,9-TETRAHYDRO-1H-PYRIDO(3,4-B)INDOL-1-YL)PHENYL)ACRYLIC ACID, ESTROGEN RECEPTOR 著者 Norman, R.A, Weir, H.M, Bradbury, R.H, Lawson, M, Rabow, A.A, Buttar, D, Callis, R.J, Curwen, J.O, de Almeida, C, Ballard, P, Hulse, M, Donald, C.S, Feron, L.J.L, Gingell, H, Karoutchi, G, MacFaul, P, Moss, T, Pearson, S.E, Tonge, M, Davies, G, Walker, G.E, Wilson, Z, Rowlinson, R, Powell, S, Hemsley, P, Linney, E, Campbell, H, Ghazoui, Z, Sadler, C, Richmond, G, Pazolli, E, Mazzola, A.M, DCruz, C, De Savi, C. 登録日 2015-08-15 公開日 2015-12-16 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. J.Med.Chem., 58, 2015
5AAU	Optimization of a novel binding motif to to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H- pyrido(3,4-b)indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonist 分子名称: 3-(1-(4-Chlorophenyl)-3,4-dihydro-1H-pyrido(3,4-b)indol-2(9H)-yl)propanoic acid, ESTROGEN RECEPTOR 著者 Norman, R.A, Bradbury, R.H, de Almeida, C, Andrews, D.M, Ballard, P, Buttar, D, Callis, R.J, Currie, G.S, Curwen, J.O, Davies, C.D, de Savi, C, Donald, C.S, Feron, L.J.L, Glossop, S.C, Hayter, B.R, Karoutchi, G, Lamont, S.G, MacFaul, P, Moss, T, Pearson, S.E, Rabow, A.A, Tonge, M, Walker, G.E, Weir, H.M, Wilson, Z. 登録日 2015-07-28 公開日 2015-10-14 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimization of a Novel Binding Motif to (E)-3-(3,5-Difluoro-4-((1R,3R)-2-(2-Fluoro-2-Methylpropyl)-3-Methyl-2, 3,4,9-Tetrahydro-1H-Pyrido[3,4-B]Indol-1-Yl)Phenyl)Acrylic Acid (Azd9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist. J.Med.Chem., 58, 2015
2M0P	Solution structure of the tenth complement type repeat of human megalin 分子名称: CALCIUM ION, Low-density lipoprotein receptor-related protein 2 著者 Dagil, R, Kragelund, B. 登録日 2012-11-01 公開日 2013-01-09 最終更新日 2023-06-14 実験手法 SOLUTION NMR 主引用文献 Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin. J.Biol.Chem., 288, 2013
5AI2	Anomalous Neutron phased crystal structure of 113Cd-substituted Perdeuterated Pyrococcus furiosus rubredoxin to 1.75A resolution at 295K 分子名称: CADMIUM ION, RUBREDOXIN, deuterium(1+) 著者 Cuypers, M.G, Mossou, E, Mason, S.A. 登録日 2015-02-11 公開日 2016-03-02 最終更新日 2024-05-08 実験手法 NEUTRON DIFFRACTION (1.75 Å) 主引用文献 Macromolecular Structure Phasing by Neutron Anomalous Diffraction. Sci.Rep., 6, 2016
3VP3	Crystal structure of human glutaminase in complex with inhibitor 3 分子名称: 5,5'-pentane-1,5-diylbis(1,3,4-thiadiazol-2-amine), Glutaminase kidney isoform, mitochondrial, ... 著者 Thangavelu, K, Sivaraman, J. 登録日 2012-02-23 公開日 2012-06-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
4XG2	Crystal structure of ligand-free Syk 分子名称: Tyrosine-protein kinase SYK 著者 Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. 登録日 2014-12-30 公開日 2015-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.21 Å) 主引用文献 Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
4XG8	Crystal structure of an inhibitor-bound Syk 分子名称: 1-[(1-{2-[(3-chloro-1-methyl-1H-indazol-5-yl)amino]pyrimidin-4-yl}-3-methyl-1H-pyrazol-4-yl)methyl]azetidin-3-ol, Tyrosine-protein kinase SYK 著者 Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. 登録日 2014-12-30 公開日 2015-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
3VT3	Crystal structures of rat VDR-LBD with R270L mutation 分子名称: 1,2-ETHANEDIOL, 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, COACTIVATOR PEPTIDE DRIP, ... 著者 Nakabayashi, M, Shimizu, M, Ikura, T, Ito, N. 登録日 2012-05-19 公開日 2013-05-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. J.Med.Chem., 56, 2013
3VT9	Crystal structures of rat VDR-LBD with W282R mutation 分子名称: (1R,2Z,3R,5E,7E,9beta,17beta)-2-(2-hydroxyethylidene)-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-9-(prop-2-en-1-yl)-9,10-secoestra-5,7-diene-1,3-diol, COACTIVATOR PEPTIDE DRIP, Vitamin D3 receptor 著者 Nakabayashi, M, Shimizu, M, Ikura, T, Ito, N. 登録日 2012-05-19 公開日 2013-05-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. J.Med.Chem., 56, 2013
3W27	The high-resolution crystal structure of TsXylA, intracellular xylanase from /Thermoanaerobacterium saccharolyticum JW/SL-YS485/: the complex of the E251A mutant with xylobiose 分子名称: Glycoside hydrolase family 10, beta-D-xylopyranose-(1-4)-alpha-D-xylopyranose 著者 Han, X, Gao, J, Shang, N, Huang, C.-H, Ko, T.-P, Zhu, Z, Wiegel, J, Shao, W, Guo, R.-T. 登録日 2012-11-27 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.41 Å) 主引用文献 Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485 Proteins, 81, 2013
3VTD	Crystal structure of rat vitamin D receptor bound to a partial agonist 26-adamantyl-23-yne-19-norvitammin D ADTK4 分子名称: (1R,3R,7E,17beta)-17-{(2R,6S)-6-hydroxy-7-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]hept-4-yn-2-yl}-2-methylidene-9,10-secoestra-5,7-diene-1,3-diol, COACTIVATOR PEPTIDE DRIP, Vitamin D3 receptor 著者 Nakabayashi, M, Kudo, T, Tokiwa, H, Makishima, M, Yamada, S, Ikura, T, Ito, N. 登録日 2012-05-26 公開日 2013-06-12 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor. J.Med.Chem., 2014
4XG3	Crystal structure of an inhibitor-bound Syk 分子名称: 4-{[5-fluoro-4-(3-{[(3R)-3-hydroxypyrrolidin-1-yl]methyl}-4-methyl-1H-pyrrol-1-yl)pyrimidin-2-yl]amino}-2,6-dimethylphenyl methanesulfonate, Tyrosine-protein kinase SYK 著者 Lee, S.J, Choi, J, Han, B.G, Song, H, Koh, J.S, Lee, B.I. 登録日 2014-12-30 公開日 2015-12-30 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Crystal structures of spleen tyrosine kinase in complex with novel inhibitors: structural insights for design of anticancer drugs Febs J., 283, 2016
2MLL	MISTLETOE LECTIN I FROM VISCUM ALBUM 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (RIBOSOME-INACTIVATING PROTEIN TYPE II) 著者 Krauspenhaar, R, Eschenburg, S, Perbandt, M, Kornilov, V, Konareva, N, Mikailova, I, Stoeva, S, Wacker, R, Maier, T, Singh, T.P, Mikhailov, A, Voelter, W, Betzel, C. 登録日 1999-03-16 公開日 2000-03-20 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Crystal structure of mistletoe lectin I from Viscum album. Biochem.Biophys.Res.Commun., 257, 1999
3W25	The high-resolution crystal structure of TsXylA, intracellular xylanase from /Thermoanaerobacterium saccharolyticum JW/SL-YS485/: the complex of the E146A mutant with xylobiose 分子名称: Glycoside hydrolase family 10, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose 著者 Han, X, Gao, J, Shang, N, Huang, C.-H, Ko, T.-P, Zhu, Z, Wiegel, J, Shao, W, Guo, R.-T. 登録日 2012-11-27 公開日 2013-04-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.32 Å) 主引用文献 Structural and functional analyses of catalytic domain of GH10 xylanase from Thermoanaerobacterium saccharolyticum JW/SL-YS485 Proteins, 81, 2013
3VP1	Crystal structure of human glutaminase in complex with L-glutamate and BPTES 分子名称: GLUTAMIC ACID, Glutaminase kidney isoform, mitochondrial, ... 著者 Thangavelu, K, Sivaraman, J. 登録日 2012-02-23 公開日 2012-06-13 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structural basis for the allosteric inhibitory mechanism of human kidney-type glutaminase (KGA) and its regulation by Raf-Mek-Erk signaling in cancer cell metabolism. Proc.Natl.Acad.Sci.USA, 109, 2012
2M8T	Solution NMR structure of the V209M variant of the human prion protein (residues 90-231) 分子名称: Major prion protein 著者 Mills, J.L, Surewicz, K, Surewicz, W, Soennichsen, F.D. 登録日 2013-05-28 公開日 2013-09-11 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Thermodynamic Stabilization of the Folded Domain of Prion Protein Inhibits Prion Infection in Vivo. Cell Rep, 4, 2013
4XE0	Idelalisib bound to the p110 subunit of PI3K delta 分子名称: 5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4(3H)-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 著者 Somoza, J.R, Villasenor, A. 登録日 2014-12-20 公開日 2015-02-04 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (2.434 Å) 主引用文献 Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase delta. J.Biol.Chem., 290, 2015
4XFO	Structure of an amyloid-forming segment TAVVTN from human Transthyretin 分子名称: Amyloid-forming peptide TAVVTN 著者 Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S. 登録日 2014-12-27 公開日 2015-10-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.35 Å) 主引用文献 Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015
4XLW	Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2) 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Delta-like protein, ... 著者 Luca, V.C, Jude, K.M, Garcia, K.C. 登録日 2015-01-13 公開日 2015-03-04 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (3.39 Å) 主引用文献 Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science, 347, 2015
3VT8	Crystal structures of rat VDR-LBD with W282R mutation 分子名称: (1R,3R,7E,9beta,17beta)-9-butyl-17-[(2R)-6-hydroxy-6-methylheptan-2-yl]-9,10-secoestra-5,7-diene-1,3-diol, COACTIVATOR PEPTIDE DRIP, Vitamin D3 receptor 著者 Nakabayashi, M, Shimizu, M, Ikura, T, Ito, N. 登録日 2012-05-19 公開日 2013-05-22 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Crystal structures of hereditary vitamin D-resistant rickets-associated vitamin D receptor mutants R270L and W282R bound to 1,25-dihydroxyvitamin D3 and synthetic ligands. J.Med.Chem., 56, 2013
3VUC	Human renin in complex with compound 5 分子名称: (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-[(1R,2S,3S,5S,7S)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]hexanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin 著者 Takahashi, M, Matsui, Y, Hanzawa, H. 登録日 2012-06-26 公開日 2013-05-15 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. Acs Med.Chem.Lett., 3, 2012
3VMK	3-isopropylmalate dehydrogenase from Shewanella benthica DB21 MT-2 分子名称: 3-ISOPROPYLMALIC ACID, 3-isopropylmalate dehydrogenase, CHLORIDE ION, ... 著者 Nagae, T, Watanabe, N. 登録日 2011-12-13 公開日 2012-02-29 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.48 Å) 主引用文献 Structural analysis of 3-isopropylmalate dehydrogenase from the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1 Acta Crystallogr.,Sect.F, 68, 2012
4XFN	Structure of an Amyloid forming peptide AEVVFT from Human Transthyretin 分子名称: Amyloid forming peptide AEVVFT 著者 Saelices, L, Sawaya, M, Cascio, D, Eisenberg, D.S. 登録日 2014-12-27 公開日 2015-10-21 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Uncovering the Mechanism of Aggregation of Human Transthyretin. J.Biol.Chem., 290, 2015

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