2M0P
Solution structure of the tenth complement type repeat of human megalin
Summary for 2M0P
Entry DOI | 10.2210/pdb2m0p/pdb |
Related | 2FYJ 2i1p |
NMR Information | BMRB: 18816 |
Descriptor | Low-density lipoprotein receptor-related protein 2, CALCIUM ION (2 entities in total) |
Functional Keywords | complement type repeat, receptor, megalin, ldl receptor family, lrp2, lipid binding protein |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P98164 |
Total number of polymer chains | 1 |
Total formula weight | 5914.24 |
Authors | Dagil, R.,Kragelund, B. (deposition date: 2012-11-01, release date: 2013-01-09, Last modification date: 2023-06-14) |
Primary citation | Dagil, R.,O'Shea, C.,Nykjar, A.,Bonvin, A.M.,Kragelund, B.B. Gentamicin binds to the megalin receptor as a competitive inhibitor using the common ligand binding motif of complement type repeats: insight from the nmr structure of the 10th complement type repeat domain alone and in complex with gentamicin. J.Biol.Chem., 288:4424-4435, 2013 Cited by PubMed: 23275343DOI: 10.1074/jbc.M112.434159 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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