4XE0

Idelalisib bound to the p110 subunit of PI3K delta

Summary for 4XE0

Entry DOI	10.2210/pdb4xe0/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4(3H)-one (3 entities in total)
Functional Keywords	zydelig, pi3k, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mus musculus (Mouse)
Cellular location	Cytoplasm : O35904
Total number of polymer chains	1
Total formula weight	108182.03
Authors	Somoza, J.R.,Villasenor, A. (deposition date: 2014-12-20, release date: 2015-02-04, Last modification date: 2023-09-27)
Primary citation	Somoza, J.R.,Koditek, D.,Villasenor, A.G.,Novikov, N.,Wong, M.H.,Liclican, A.,Xing, W.,Lagpacan, L.,Wang, R.,Schultz, B.E.,Papalia, G.A.,Samuel, D.,Lad, L.,McGrath, M.E. Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase delta. J.Biol.Chem., 290:8439-8446, 2015 Cited by PubMed: 25631052 DOI: 10.1074/jbc.M114.634683 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.434 Å)

Structure validation