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3GCW
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BU of 3gcw by Molmil
PCSK9:EGFA(H306Y)
分子名称: CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9
著者Kwon, H.J.
登録日2009-02-22
公開日2009-03-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells.
J.Biol.Chem., 284, 2009
3HOY
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BU of 3hoy by Molmil
Complete RNA polymerase II elongation complex VI
分子名称: 5'-D(*CP*CP*AP*AP*GP*CP*TP*CP*AP*AP*G*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*TP*AP*CP*TP*AP*GP*TP*AP*CP*TP*GP*CP*C)-3', 5'-D(*CP*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*AP*GP*TP*AP*AP*AP*CP*TP*AP*GP*TP*AP*TP*T*GP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP*T)-3', 5'-R(*UP*AP*UP*AP*UP*GP*CP*A*UP*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*A)-3', ...
著者Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P.
登録日2009-06-03
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
Mol.Cell, 34, 2009
3HOR
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BU of 3hor by Molmil
Structure of the actin-binding domain of human filamin A (reduced)
分子名称: Filamin-A, PHOSPHATE ION
著者Clark, A.R, Sawyer, G.M, Robertson, S.P, Sutherland-Smith, A.J.
登録日2009-06-03
公開日2009-10-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders
Hum.Mol.Genet., 18, 2009
3HQD
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BU of 3hqd by Molmil
Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+
分子名称: Kinesin-like protein KIF11, MAGNESIUM ION, PHOSPHATE ION, ...
著者Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K.
登録日2009-06-05
公開日2009-12-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism.
J.Biol.Chem., 285, 2010
2WIK
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BU of 2wik by Molmil
NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Carletti, E, Aurbek, N, Gillon, E, Loiodice, M, Nicolet, Y, Fontecilla, J, Masson, P, Thiermann, H, Nachon, F, Worek, F.
登録日2009-05-12
公開日2009-05-19
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
3HRB
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BU of 3hrb by Molmil
p38 kinase Crystal structure in complex with small molecule inhibitor
分子名称: Mitogen-activated protein kinase 14, [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone
著者Segarra, V, Lumeras, W, Vidal, B, Leonard, P, Fisher, M, Lamers, M.
登録日2009-06-09
公開日2009-09-01
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase
J.Med.Chem., 52, 2009
3HV6
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BU of 3hv6 by Molmil
Human p38 MAP Kinase in Complex with RL39
分子名称: 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside
著者Gruetter, C, Simard, J.R, Getlik, M, Rauh, D.
登録日2009-06-15
公開日2009-11-17
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Displacement assay for the detection of stabilizers of inactive kinase conformations.
J.Med.Chem., 53, 2010
2WII
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BU of 2wii by Molmil
Complement C3b in complex with factor H domains 1-4
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C3 BETA CHAIN, ...
著者Wu, J, Janssen, B.J.C, Gros, P.
登録日2009-05-12
公開日2009-06-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of complement fragment C3b-factor H and implications for host protection by complement regulators.
Nat. Immunol., 10, 2009
2WMN
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BU of 2wmn by Molmil
Structure of the complex between DOCK9 and Cdc42-GDP.
分子名称: CELL DIVISION CONTROL PROTEIN 42 HOMOLOG, DEDICATOR OF CYTOKINESIS PROTEIN 9, GUANOSINE-5'-DIPHOSPHATE
著者Yang, J, Roe, S.M, Barford, D.
登録日2009-07-02
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.391 Å)
主引用文献Activation of Rho Gtpases by Dock Exchange Factors is Mediated by a Nucleotide Sensor.
Science, 325, 2009
2WQM
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BU of 2wqm by Molmil
Structure of apo human Nek7
分子名称: NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION
著者Richards, M.W, Bayliss, R.
登録日2009-08-24
公開日2009-12-08
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9
Mol.Cell, 36, 2009
3FZZ
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BU of 3fzz by Molmil
Structure of GrC
分子名称: Granzyme C, SULFATE ION
著者Buckle, A.M, Kaiserman, D, Whisstock, J.C.
登録日2009-01-27
公開日2009-03-17
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structure of granzyme C reveals an unusual mechanism of protease autoinhibition
Proc.Natl.Acad.Sci.USA, 106, 2009
2WK5
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BU of 2wk5 by Molmil
Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
分子名称: GLYCEROL, THYMIDINE PHOSPHORYLASE
著者Mitsiki, E, Papageorgiou, A.C, Iyer, S, Thiyagarajan, N, Prior, S.H, Sleep, D, Finnis, C, Acharya, K.R.
登録日2009-06-05
公開日2009-07-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil.
Biochem.Biophys.Res.Commun., 386, 2009
3KWW
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BU of 3kww by Molmil
Crystal structure of the 'restriction triad' mutant of HLA B*3508, beta-2-microglobulin and EBV peptide
分子名称: ACETIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ...
著者Archbold, J.K, Tynan, F.E, Gras, S, Rossjohn, J.
登録日2009-12-01
公開日2010-06-09
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability
Proc.Natl.Acad.Sci.USA, 2010
3DMU
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BU of 3dmu by Molmil
Crystal structure of Staphylococcal nuclease variant PHS T62K at cryogenic temperature
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Thermonuclease
著者Khangulov, V.S, Schlessman, J.L, Garcia-Moreno, E.B, Benning, M, Isom, D.
登録日2008-07-01
公開日2008-11-04
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of Staphylococcal nuclease variant PHS T62K at cryogenic temperature
To be Published
3KZE
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BU of 3kze by Molmil
Crystal Structure of T-cell Lymphoma Invasion and Metastasis-1 PDZ in Complex With SSRKEYYA Peptide
分子名称: Synthetic Peptide, T-lymphoma invasion and metastasis-inducing protein 1
著者Shepherd, T.R, Fuentes, E.J.
登録日2009-12-08
公開日2010-04-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
J.Mol.Biol., 398, 2010
3DE5
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BU of 3de5 by Molmil
roteinase K by Classical hanging drop method after the second step of high X-Ray dose on ESRF ID23-1 beamline
分子名称: CALCIUM ION, Proteinase K
著者Pechkova, E, Tripathi, S.K, Nicolini, C.
登録日2008-06-08
公開日2009-06-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Radiation stability of proteinase K crystals grown by LB nanotemplate method
J.Struct.Biol., 168, 2009
3DO1
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BU of 3do1 by Molmil
Thermolysin by Classical hanging drop method before high X-Ray dose on ESRF ID14-2 beamline
分子名称: CALCIUM ION, LYSINE, Thermolysin, ...
著者Pechkova, E, Tripathi, S.K, Nicolini, C.
登録日2008-07-03
公開日2009-07-07
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Radiation damage in protein structural characterization by Synchrotron Radiation: State of the art and Nanotechnology-based perspective
To be Published
3L4X
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BU of 3l4x by Molmil
Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8
分子名称: (1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Sim, L, Rose, D.R.
登録日2009-12-21
公開日2010-02-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry, 49, 2010
3DOR
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BU of 3dor by Molmil
Crystal Structure of mature CPAF
分子名称: Protein CT_858, SULFATE ION
著者Chai, J, Huang, Z.
登録日2008-07-06
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3DPM
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BU of 3dpm by Molmil
Structure of mature CPAF complexed with lactacystin
分子名称: N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine, Protein CT_858
著者Chai, J, Huang, Z.
登録日2008-07-09
公開日2009-01-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural basis for activation and inhibition of the secreted chlamydia protease CPAF
Cell Host Microbe, 4, 2008
3L4T
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BU of 3l4t by Molmil
Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661
分子名称: (1R,2S)-1-[(1S)-1,2-dihydroxyethyl]-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-2-hydroxypropyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltase-glucoamylase, ...
著者Sim, L, Rose, D.R.
登録日2009-12-21
公開日2010-02-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry, 49, 2010
3DHY
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BU of 3dhy by Molmil
Crystal Structures of Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase in Ternary Complex with Substrate and Inhibitors
分子名称: 5'-S-ethyl-5'-thioadenosine, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
著者Shetty, N.D, Ioerger, T.R, Gokulan, K, Reddy, M.C.M, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
登録日2008-06-19
公開日2008-09-09
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.
Protein Sci., 17, 2008
3DNI
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BU of 3dni by Molmil
CRYSTALLOGRAPHIC REFINEMENT AND STRUCTURE OF DNASE I AT 2 ANGSTROMS RESOLUTION
分子名称: CALCIUM ION, DEOXYRIBONUCLEASE I, alpha-D-galactopyranose-(1-6)-beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
著者Oefner, C, Suck, D.
登録日1992-08-20
公開日1994-01-31
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystallographic refinement and structure of DNase I at 2 A resolution.
J.Mol.Biol., 192, 1986
3DO0
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BU of 3do0 by Molmil
Thermolysin by classical hanging drop method after high X-Ray dose on esrf ID14-2 beamline
分子名称: CALCIUM ION, LYSINE, Thermolysin, ...
著者Pechkova, E, Tripathi, S.K, Nicolini, C.
登録日2008-07-03
公開日2009-07-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献Radiation damage in protein structural characterization by Synchrotron Radiation: State of the art and Nanotechnology-based perspective
To be Published
2VL9
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BU of 2vl9 by Molmil
Oxidized form of human peroxiredoxin 5
分子名称: PEROXIREDOXIN-5
著者Smeets, A, Declercq, J.P.
登録日2008-01-11
公開日2008-08-26
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The Crystal Structures of Oxidized Forms of Human Peroxiredoxin 5 with an Intramolecular Disulfide Bond Confirm the Proposed Enzymatic Mechanism for Atypical 2-Cys Peroxiredoxins.
Arch.Biochem.Biophys., 477, 2008

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