3GCW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3gcw by Molmil](/molmil-images/mine/3gcw) | PCSK9:EGFA(H306Y) | 分子名称: | CALCIUM ION, Low-density lipoprotein receptor, Proprotein convertase subtilisin/kexin type 9 | 著者 | Kwon, H.J. | 登録日 | 2009-02-22 | 公開日 | 2009-03-03 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Antagonism of Secreted PCSK9 Increases Low Density Lipoprotein Receptor Expression in HepG2 Cells. J.Biol.Chem., 284, 2009
|
|
3HOY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hoy by Molmil](/molmil-images/mine/3hoy) | Complete RNA polymerase II elongation complex VI | 分子名称: | 5'-D(*CP*CP*AP*AP*GP*CP*TP*CP*AP*AP*G*TP*AP*CP*TP*TP*AP*CP*GP*CP*CP*(BRU)P*GP*GP*TP*CP*AP*TP*TP*AP*CP*TP*AP*GP*TP*AP*CP*TP*GP*CP*C)-3', 5'-D(*CP*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*AP*GP*TP*AP*AP*AP*CP*TP*AP*GP*TP*AP*TP*T*GP*AP*AP*AP*GP*TP*AP*CP*TP*TP*GP*AP*GP*CP*TP*T)-3', 5'-R(*UP*AP*UP*AP*UP*GP*CP*A*UP*AP*AP*AP*GP*AP*CP*CP*AP*GP*GP*A)-3', ... | 著者 | Sydow, J.F, Brueckner, F, Cheung, A.C.M, Damsma, G.E, Dengl, S, Lehmann, E, Vassylyev, D, Cramer, P. | 登録日 | 2009-06-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA. Mol.Cell, 34, 2009
|
|
3HOR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hor by Molmil](/molmil-images/mine/3hor) | Structure of the actin-binding domain of human filamin A (reduced) | 分子名称: | Filamin-A, PHOSPHATE ION | 著者 | Clark, A.R, Sawyer, G.M, Robertson, S.P, Sutherland-Smith, A.J. | 登録日 | 2009-06-03 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Hum.Mol.Genet., 18, 2009
|
|
3HQD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hqd by Molmil](/molmil-images/mine/3hqd) | Human kinesin Eg5 motor domain in complex with AMPPNP and Mg2+ | 分子名称: | Kinesin-like protein KIF11, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Parke, C.L, Wojcik, E.J, Kim, S, Worthylake, D.K. | 登録日 | 2009-06-05 | 公開日 | 2009-12-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | ATP Hydrolysis in Eg5 Kinesin Involves a Catalytic Two-water Mechanism. J.Biol.Chem., 285, 2010
|
|
2WIK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wik by Molmil](/molmil-images/mine/2wik) | NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA6 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | 著者 | Carletti, E, Aurbek, N, Gillon, E, Loiodice, M, Nicolet, Y, Fontecilla, J, Masson, P, Thiermann, H, Nachon, F, Worek, F. | 登録日 | 2009-05-12 | 公開日 | 2009-05-19 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun. Biochem. J., 421, 2009
|
|
3HRB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hrb by Molmil](/molmil-images/mine/3hrb) | p38 kinase Crystal structure in complex with small molecule inhibitor | 分子名称: | Mitogen-activated protein kinase 14, [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | 著者 | Segarra, V, Lumeras, W, Vidal, B, Leonard, P, Fisher, M, Lamers, M. | 登録日 | 2009-06-09 | 公開日 | 2009-09-01 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase J.Med.Chem., 52, 2009
|
|
3HV6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hv6 by Molmil](/molmil-images/mine/3hv6) | Human p38 MAP Kinase in Complex with RL39 | 分子名称: | 1-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl]-3-[4-(2-morpholin-4-ylethoxy)phenyl]urea, Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside | 著者 | Gruetter, C, Simard, J.R, Getlik, M, Rauh, D. | 登録日 | 2009-06-15 | 公開日 | 2009-11-17 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Displacement assay for the detection of stabilizers of inactive kinase conformations. J.Med.Chem., 53, 2010
|
|
2WII
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wii by Molmil](/molmil-images/mine/2wii) | Complement C3b in complex with factor H domains 1-4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COMPLEMENT C3 BETA CHAIN, ... | 著者 | Wu, J, Janssen, B.J.C, Gros, P. | 登録日 | 2009-05-12 | 公開日 | 2009-06-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure of complement fragment C3b-factor H and implications for host protection by complement regulators. Nat. Immunol., 10, 2009
|
|
2WMN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wmn by Molmil](/molmil-images/mine/2wmn) | |
2WQM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wqm by Molmil](/molmil-images/mine/2wqm) | Structure of apo human Nek7 | 分子名称: | NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION | 著者 | Richards, M.W, Bayliss, R. | 登録日 | 2009-08-24 | 公開日 | 2009-12-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9 Mol.Cell, 36, 2009
|
|
3FZZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3fzz by Molmil](/molmil-images/mine/3fzz) | Structure of GrC | 分子名称: | Granzyme C, SULFATE ION | 著者 | Buckle, A.M, Kaiserman, D, Whisstock, J.C. | 登録日 | 2009-01-27 | 公開日 | 2009-03-17 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure of granzyme C reveals an unusual mechanism of protease autoinhibition Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
2WK5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2wk5 by Molmil](/molmil-images/mine/2wk5) | Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil | 分子名称: | GLYCEROL, THYMIDINE PHOSPHORYLASE | 著者 | Mitsiki, E, Papageorgiou, A.C, Iyer, S, Thiyagarajan, N, Prior, S.H, Sleep, D, Finnis, C, Acharya, K.R. | 登録日 | 2009-06-05 | 公開日 | 2009-07-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Structures of Native Human Thymidine Phosphorylase and in Complex with 5-Iodouracil. Biochem.Biophys.Res.Commun., 386, 2009
|
|
3KWW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kww by Molmil](/molmil-images/mine/3kww) | Crystal structure of the 'restriction triad' mutant of HLA B*3508, beta-2-microglobulin and EBV peptide | 分子名称: | ACETIC ACID, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | 著者 | Archbold, J.K, Tynan, F.E, Gras, S, Rossjohn, J. | 登録日 | 2009-12-01 | 公開日 | 2010-06-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability Proc.Natl.Acad.Sci.USA, 2010
|
|
3DMU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dmu by Molmil](/molmil-images/mine/3dmu) | Crystal structure of Staphylococcal nuclease variant PHS T62K at cryogenic temperature | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, PHOSPHATE ION, Thermonuclease | 著者 | Khangulov, V.S, Schlessman, J.L, Garcia-Moreno, E.B, Benning, M, Isom, D. | 登録日 | 2008-07-01 | 公開日 | 2008-11-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of Staphylococcal nuclease variant PHS T62K at cryogenic temperature To be Published
|
|
3KZE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3kze by Molmil](/molmil-images/mine/3kze) | |
3DE5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3de5 by Molmil](/molmil-images/mine/3de5) | |
3DO1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3do1 by Molmil](/molmil-images/mine/3do1) | |
3L4X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3l4x by Molmil](/molmil-images/mine/3l4x) | Crystal complex of N-terminal Human Maltase-Glucoamylase with NR4-8 | 分子名称: | (1S,2R,3S,4S)-1-{(1S)-2-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-1-hydroxyethyl}-2,3,4,5-tetrahydroxypentyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sim, L, Rose, D.R. | 登録日 | 2009-12-21 | 公開日 | 2010-02-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry, 49, 2010
|
|
3DOR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dor by Molmil](/molmil-images/mine/3dor) | Crystal Structure of mature CPAF | 分子名称: | Protein CT_858, SULFATE ION | 著者 | Chai, J, Huang, Z. | 登録日 | 2008-07-06 | 公開日 | 2009-01-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008
|
|
3DPM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dpm by Molmil](/molmil-images/mine/3dpm) | Structure of mature CPAF complexed with lactacystin | 分子名称: | N-acetyl-S-({(2R,3S,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxopyrrolidin-2-yl}carbonyl)cysteine, Protein CT_858 | 著者 | Chai, J, Huang, Z. | 登録日 | 2008-07-09 | 公開日 | 2009-01-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Structural basis for activation and inhibition of the secreted chlamydia protease CPAF Cell Host Microbe, 4, 2008
|
|
3L4T
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3l4t by Molmil](/molmil-images/mine/3l4t) | Crystal complex of N-terminal Human Maltase-Glucoamylase with BJ2661 | 分子名称: | (1R,2S)-1-[(1S)-1,2-dihydroxyethyl]-3-[(2R,3S,4S)-3,4-dihydroxy-2-(hydroxymethyl)tetrahydrothiophenium-1-yl]-2-hydroxypropyl sulfate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Maltase-glucoamylase, ... | 著者 | Sim, L, Rose, D.R. | 登録日 | 2009-12-21 | 公開日 | 2010-02-09 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata. Biochemistry, 49, 2010
|
|
3DHY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dhy by Molmil](/molmil-images/mine/3dhy) | Crystal Structures of Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase in Ternary Complex with Substrate and Inhibitors | 分子名称: | 5'-S-ethyl-5'-thioadenosine, Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Shetty, N.D, Ioerger, T.R, Gokulan, K, Reddy, M.C.M, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2008-06-19 | 公開日 | 2008-09-09 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors. Protein Sci., 17, 2008
|
|
3DNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3dni by Molmil](/molmil-images/mine/3dni) | CRYSTALLOGRAPHIC REFINEMENT AND STRUCTURE OF DNASE I AT 2 ANGSTROMS RESOLUTION | 分子名称: | CALCIUM ION, DEOXYRIBONUCLEASE I, alpha-D-galactopyranose-(1-6)-beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Oefner, C, Suck, D. | 登録日 | 1992-08-20 | 公開日 | 1994-01-31 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystallographic refinement and structure of DNase I at 2 A resolution. J.Mol.Biol., 192, 1986
|
|
3DO0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3do0 by Molmil](/molmil-images/mine/3do0) | |
2VL9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2vl9 by Molmil](/molmil-images/mine/2vl9) | Oxidized form of human peroxiredoxin 5 | 分子名称: | PEROXIREDOXIN-5 | 著者 | Smeets, A, Declercq, J.P. | 登録日 | 2008-01-11 | 公開日 | 2008-08-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The Crystal Structures of Oxidized Forms of Human Peroxiredoxin 5 with an Intramolecular Disulfide Bond Confirm the Proposed Enzymatic Mechanism for Atypical 2-Cys Peroxiredoxins. Arch.Biochem.Biophys., 477, 2008
|
|