3DHY

Crystal Structures of Mycobacterium tuberculosis S-Adenosyl-L-Homocysteine Hydrolase in Ternary Complex with Substrate and Inhibitors

Summary for 3DHY

• Entry DOI: 10.2210/pdb3dhy/pdb
• Related: 2ZIZ 2ZJ0 2ZJ1 3CE6
• Descriptor: Adenosylhomocysteinase, 5'-S-ethyl-5'-thioadenosine, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... (4 entities in total)
• Functional Keywords: protein-substrate complex, dimer of dimers, nad binding domain, 37 amino acid insertion, solvent access channel, structural genomics, tuberculosis structural genomics consortium, tb structural genomics consortium, tbsgc, cytoplasm, hydrolase, nad, one-carbon metabolism, psi-2, protein structure initiative
• Biological source: Mycobacterium tuberculosis
• Cellular location: Cytoplasm (By similarity): P60176
• Total number of polymer chains: 4
• Total formula weight: 221448.78

Authors

Shetty, N.D.,Ioerger, T.R.,Gokulan, K.,Reddy, M.C.M.,Owen, J.L.,Sacchettini, J.C.,TB Structural Genomics Consortium (TBSGC) (deposition date: 2008-06-19, release date: 2008-09-09, Last modification date: 2023-08-30)

• Primary citation: Reddy, M.C.,Kuppan, G.,Shetty, N.D.,Owen, J.L.,Ioerger, T.R.,Sacchettini, J.C.; Crystal structures of Mycobacterium tuberculosis S-adenosyl-L-homocysteine hydrolase in ternary complex with substrate and inhibitors.; Protein Sci., 17:2134-2144, 2008; PubMed: 18815415; DOI: 10.1110/ps.038125.108

Experimental method

X-RAY DIFFRACTION (2 Å)