6ZE8
 
 | | Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01 | | 分子名称: | 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine, Chitotriosidase-1, GLYCEROL, ... | | 著者 | Nowotny, M, Bartlomiejczak, A, Napiorkowska-Gromadzka, A. | | 登録日 | 2020-06-16 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Discovery of OATD-01 , a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
J.Med.Chem., 63, 2020
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6HLS
 | | Yeast apo RNA polymerase I* | | 分子名称: | DNA-directed RNA polymerase I subunit RPA12, DNA-directed RNA polymerase I subunit RPA135, DNA-directed RNA polymerase I subunit RPA14, ... | | 著者 | Tafur, L, Sadian, Y, Weis, F, Muller, C.W. | | 登録日 | 2018-09-11 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2.
Elife, 8, 2019
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6ZJ3
 | | Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis | | 分子名称: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | | 著者 | Matzov, D, Halfon, H, Zimmerman, E, Rozenberg, H, Bashan, A, Gray, M.W, Yonath, A.E, Shalev-Benami, M. | | 登録日 | 2020-06-27 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | | 主引用文献 | Cryo-EM structure of the highly atypical cytoplasmic ribosome of Euglena gracilis.
Nucleic Acids Res., 48, 2020
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6D3Z
 | | Protease SFTI complex | | 分子名称: | Plasminogen, Trypsin inhibitor 1 | | 著者 | Law, R.H.P, Wu, G. | | 登録日 | 2018-04-17 | | 公開日 | 2019-01-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma.
J. Med. Chem., 62, 2019
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7OKA
 | | Crystal structure of Pseudomonas aeruginosa LpxA in complex with compound 14 | | 分子名称: | 2-(2-chlorophenyl)sulfanyl-~{N}-[(4-cyanophenyl)methyl]-~{N}-(1~{H}-imidazol-4-ylmethyl)ethanamide, Acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase, CHLORIDE ION, ... | | 著者 | Ryan, M.D, Parkes, A.L, Southey, M, Andersen, O.A, Zahn, M, Barker, J, DeJonge, B.L.M. | | 登録日 | 2021-05-17 | | 公開日 | 2021-10-13 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Discovery of Novel UDP- N -Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa .
J.Med.Chem., 64, 2021
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1HAQ
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6DD1
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6DLL
 | | 2.2 Angstrom Resolution Crystal Structure of P-Hydroxybenzoate Hydroxylase from Pseudomonas putida in Complex with FAD. | | 分子名称: | CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, FORMIC ACID, ... | | 著者 | Minasov, G, Shuvalova, L, Kiryukhina, O, Dubrovska, I, Grimshaw, S, Kwon, K, Anderson, W.F, Satchell, K.J.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2018-06-01 | | 公開日 | 2018-06-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural comparison of p-hydroxybenzoate hydroxylase (PobA) from Pseudomonas putida with PobA from other Pseudomonas spp. and other monooxygenases.
Acta Crystallogr.,Sect.F, 75, 2019
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6D6L
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6D40
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7P7L
 | | Complex I from E. coli, DDM/LMNG-purified, with NADH and FMN, Open state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | | 登録日 | 2021-07-19 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | A universal coupling mechanism of respiratory complex I.
Nature, 609, 2022
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7P61
 | | Complex I from E. coli, DDM-purified, with NADH, Resting state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | | 登録日 | 2021-07-15 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A universal coupling mechanism of respiratory complex I.
Nature, 609, 2022
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7P7C
 | | Complex I from E. coli, DDM/LMNG-purified, Apo, Open state | | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | | 著者 | Kravchuk, V, Kampjut, D, Sazanov, L. | | 登録日 | 2021-07-19 | | 公開日 | 2022-09-21 | | 最終更新日 | 2024-07-17 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | A universal coupling mechanism of respiratory complex I.
Nature, 609, 2022
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8RC4
 | | Structure of Integrator-PP2A complex | | 分子名称: | DSS1, Integrator complex subunit 1, Integrator complex subunit 10, ... | | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | | 登録日 | 2023-12-06 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
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8RBZ
 | | Structure of Integrator-PP2A-SOSS-CTD post-termination complex | | 分子名称: | DNA-directed RNA polymerase subunit, DSS1, Integrator complex subunit 1, ... | | 著者 | Fianu, I, Ochmann, M, Walshe, J.L, Cramer, P. | | 登録日 | 2023-12-05 | | 公開日 | 2024-02-07 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural basis of Integrator-dependent RNA polymerase II termination.
Nature, 629, 2024
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2AYO
 | | Structure of USP14 bound to ubquitin aldehyde | | 分子名称: | Ubiquitin, Ubiquitin carboxyl-terminal hydrolase 14 | | 著者 | Hu, M, Li, P, Jeffrey, P.D, Shi, Y. | | 登録日 | 2005-09-07 | | 公開日 | 2005-10-18 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14.
Embo J., 24, 2005
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6IMA
 | | Crystal Structure of ALKBH1 without alpha-1 (N37-C369) | | 分子名称: | CITRIC ACID, Nucleic acid dioxygenase ALKBH1 | | 著者 | Zhang, M, Yang, S, Zhao, W, Li, H. | | 登録日 | 2018-10-22 | | 公開日 | 2020-01-22 | | 最終更新日 | 2020-04-08 | | 実験手法 | X-RAY DIFFRACTION (2.593 Å) | | 主引用文献 | Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA.
Cell Res., 30, 2020
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7AZY
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4DH0
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1ZWJ
 | | X-ray structure of galt-like protein from arabidopsis thaliana AT5G18200 | | 分子名称: | ZINC ION, putative galactose-1-phosphate uridyl transferase | | 著者 | Wesenberg, G.E, Smith, D.W, Phillips Jr, G.N, McCoy, J.G, Johnson, K.A, Bitto, E, Bingman, C.A, Allard, S.T.M, Center for Eukaryotic Structural Genomics (CESG) | | 登録日 | 2005-06-03 | | 公開日 | 2005-06-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure and Mechanism of an ADP-Glucose Phosphorylase from
Arabidopsis thaliana
Biochemistry, 45, 2006
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7AQQ
 | | Cryo-EM structure of Arabidopsis thaliana Complex-I (membrane core) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | | 著者 | Klusch, N, Kuehlbrandt, W, Yildiz, O. | | 登録日 | 2020-10-22 | | 公開日 | 2021-12-08 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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6ZQF
 | | Cryo-EM structure of the 90S pre-ribosome from Saccharomyces cerevisiae, state Dis-B (Poly-Ala) | | 分子名称: | 18S rRNA, 40S ribosomal protein S1-A, 40S ribosomal protein S11-A, ... | | 著者 | Cheng, J, Lau, B, Venuta, G.L, Berninghausen, O, Hurt, E, Beckmann, R. | | 登録日 | 2020-07-09 | | 公開日 | 2020-09-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | 90 S pre-ribosome transformation into the primordial 40 S subunit.
Science, 369, 2020
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7AR8
 | | Cryo-EM structure of Arabidopsis thaliana complex-I (closed conformation) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | | 著者 | Klusch, N, Kuelbrandt, W, Yildiz, O. | | 登録日 | 2020-10-23 | | 公開日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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7ARB
 | | Cryo-EM structure of Arabidopsis thaliana Complex-I (complete composition) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | | 著者 | Klusch, N, Kuelbrandt, W, Yildiz, O. | | 登録日 | 2020-10-23 | | 公開日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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7AR7
 | | Cryo-EM structure of Arabidopsis thaliana complex-I (open conformation) | | 分子名称: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, (7S)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, ... | | 著者 | Klusch, N, Kuelbrandt, W. | | 登録日 | 2020-10-23 | | 公開日 | 2022-03-02 | | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | | 主引用文献 | A ferredoxin bridge connects the two arms of plant mitochondrial complex I.
Plant Cell, 33, 2021
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