4DH0

X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?

Summary for 4DH0

• Entry DOI: 10.2210/pdb4dh0/pdb
• Related: 1fkl
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, 28-O-Methylrapamycin (3 entities in total)
• Functional Keywords: peptidyl-prolyl cis-trans isomerase, isomerase-immunosuppressant complex, isomerase/immunosuppressant
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm, cytosol : P62942
• Total number of polymer chains: 1
• Total formula weight: 12764.71

Authors

Kallen, J. (deposition date: 2012-01-27, release date: 2012-02-15, Last modification date: 2024-02-28)

• Primary citation: Kallen, J.,Sedrani, R.,Cottens, S.; X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?; J.Am.Chem.Soc., 118:5857-5861, 1996; DOI: 10.1021/ja954328h

Experimental method

X-RAY DIFFRACTION (2.1 Å)