4DH0
X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
Summary for 4DH0
Entry DOI | 10.2210/pdb4dh0/pdb |
Related | 1fkl |
Descriptor | Peptidyl-prolyl cis-trans isomerase FKBP1A, 28-O-Methylrapamycin (3 entities in total) |
Functional Keywords | peptidyl-prolyl cis-trans isomerase, isomerase-immunosuppressant complex, isomerase/immunosuppressant |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytosol : P62942 |
Total number of polymer chains | 1 |
Total formula weight | 12764.71 |
Authors | Kallen, J. (deposition date: 2012-01-27, release date: 2012-02-15, Last modification date: 2024-02-28) |
Primary citation | Kallen, J.,Sedrani, R.,Cottens, S. X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin? J.Am.Chem.Soc., 118:5857-5861, 1996 Cited by DOI: 10.1021/ja954328hPDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report