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4DH0

X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?

Summary for 4DH0
Entry DOI10.2210/pdb4dh0/pdb
Related1fkl
DescriptorPeptidyl-prolyl cis-trans isomerase FKBP1A, 28-O-Methylrapamycin (3 entities in total)
Functional Keywordspeptidyl-prolyl cis-trans isomerase, isomerase-immunosuppressant complex, isomerase/immunosuppressant
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytosol : P62942
Total number of polymer chains1
Total formula weight12764.71
Authors
Kallen, J. (deposition date: 2012-01-27, release date: 2012-02-15, Last modification date: 2024-02-28)
Primary citationKallen, J.,Sedrani, R.,Cottens, S.
X-ray Crystal Structure of 28-O-Methylrapamycin complexed with FKBP12: Is the Cyclohexyl Moiety Part of the Effector Domain of Rapamycin?
J.Am.Chem.Soc., 118:5857-5861, 1996
Cited by
DOI: 10.1021/ja954328h
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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