1FKL
ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX
Summary for 1FKL
Entry DOI | 10.2210/pdb1fkl/pdb |
Descriptor | FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG (3 entities in total) |
Functional Keywords | fk506 binding protein, fkbp12, fkbp, cis-trans prolyl-isomerase, rotamase |
Biological source | Bos taurus (cattle) |
Total number of polymer chains | 1 |
Total formula weight | 12708.60 |
Authors | Wilson, K.P.,Sintchak, M.D.,Thomson, J.A.,Navia, M.A. (deposition date: 1995-08-18, release date: 1995-12-07, Last modification date: 2024-02-07) |
Primary citation | Wilson, K.P.,Yamashita, M.M.,Sintchak, M.D.,Rotstein, S.H.,Murcko, M.A.,Boger, J.,Thomson, J.A.,Fitzgibbon, M.J.,Black, J.R.,Navia, M.A. Comparative X-ray structures of the major binding protein for the immunosuppressant FK506 (tacrolimus) in unliganded form and in complex with FK506 and rapamycin. Acta Crystallogr.,Sect.D, 51:511-521, 1995 Cited by PubMed: 15299838DOI: 10.1107/S0907444994014514 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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