1FKL

ATOMIC STRUCTURE OF FKBP12-RAPAYMYCIN, AN IMMUNOPHILIN-IMMUNOSUPPRESSANT COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0001933	biological_process	negative regulation of protein phosphorylation
A	0003007	biological_process	heart morphogenesis
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005528	molecular_function	FK506 binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006936	biological_process	muscle contraction
A	0007183	biological_process	obsolete SMAD protein complex assembly
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016529	cellular_component	sarcoplasmic reticulum
A	0016853	molecular_function	isomerase activity
A	0019221	biological_process	cytokine-mediated signaling pathway
A	0019855	molecular_function	calcium channel inhibitor activity
A	0030018	cellular_component	Z disc
A	0031000	biological_process	response to caffeine
A	0031398	biological_process	positive regulation of protein ubiquitination
A	0032092	biological_process	positive regulation of protein binding
A	0032515	biological_process	obsolete negative regulation of phosphoprotein phosphatase activity
A	0032880	biological_process	regulation of protein localization
A	0032925	biological_process	regulation of activin receptor signaling pathway
A	0033017	cellular_component	sarcoplasmic reticulum membrane
A	0042098	biological_process	T cell proliferation
A	0042110	biological_process	T cell activation
A	0042803	molecular_function	protein homodimerization activity
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0044325	molecular_function	transmembrane transporter binding
A	0046332	molecular_function	SMAD binding
A	0048185	molecular_function	activin binding
A	0050776	biological_process	regulation of immune response
A	0051209	biological_process	release of sequestered calcium ion into cytosol
A	0051280	biological_process	negative regulation of release of sequestered calcium ion into cytosol
A	0055010	biological_process	ventricular cardiac muscle tissue morphogenesis
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0060347	biological_process	heart trabecula formation
A	0070062	cellular_component	extracellular exosome
A	0097435	biological_process	supramolecular fiber organization
A	0098562	cellular_component	cytoplasmic side of membrane
A	1902991	biological_process	regulation of amyloid precursor protein catabolic process
A	1990000	biological_process	amyloid fibril formation
A	1990425	cellular_component	ryanodine receptor complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE RAP A 108

Chain	Residue
A	THR6
A	VAL55
A	ILE56
A	TRP59
A	ARG71
A	TYR82
A	ASP100
A	HOH127
A	HOH130
A	HOH168
A	ILE7
A	TYR26
A	THR27
A	PHE36
A	ASP37
A	PHE46
A	GLN53
A	GLU54

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"PPIase FKBP-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00277","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P26883","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1d6o

Chain	Residue	Details
A	ILE56
A	TYR82
A	ASP37

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