5V9L
 
 | |
5UQW
 | | Crystal structure of human KRAS G12V mutant in complex with GDP | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Huang, C.S, Kaplan, A, Stockwell, B.R, Tong, L. | | 登録日 | 2017-02-08 | | 公開日 | 2017-03-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell, 168, 2017
|
|
5VPY
 | | Crystal structure of human KRAS G12A mutant in complex with GppNHp | | 分子名称: | 2-amino-9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonoamino)phosphoryl]oxy}phosphoryl]-alpha-L-xylofuranosyl}-1,9-dihydro-6H-purin-6-one, GTPase KRas, MAGNESIUM ION, ... | | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | | 登録日 | 2017-05-06 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VQ2
 | | Crystal structure of human WT-KRAS in complex with GTP | | 分子名称: | GTPase KRas, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | | 登録日 | 2017-05-07 | | 公開日 | 2017-12-06 | | 最終更新日 | 2017-12-20 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Acta Crystallogr D Struct Biol, 73, 2017
|
|
5VQ8
 | | Crystal structure of human WT-KRAS in complex with GDP (EDTA soaked) | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | 著者 | Xu, S, Long, B, Boris, G, Ni, S, Kennedy, M.A. | | 登録日 | 2017-05-08 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural insight into the rearrangement of the switch I region in GTP-bound G12A K-Ras.
Acta Crystallogr D Struct Biol, 73, 2017
|
|
5WDQ
 | | H-Ras mutant L120A bound to GMP-PNP at 100K | | 分子名称: | ACETATE ION, CALCIUM ION, GTPase HRas, ... | | 著者 | Bandaru, P, Gee, C.L, Kuriyan, J. | | 登録日 | 2017-07-05 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
|
|
5WHD
 | | Crystal structure of KRas G12V/D38P, bound to GDP | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE | | 著者 | Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. | | 登録日 | 2017-07-16 | | 公開日 | 2018-01-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.641 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5US4
 | | Crystal structure of human KRAS G12D mutant in complex with GDP | | 分子名称: | GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Tran, T, Kaplan, A, Stockwell, B.R, Tong, L. | | 登録日 | 2017-02-13 | | 公開日 | 2017-03-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell, 168, 2017
|
|
5WDS
 | | Choanoflagellate Salpingoeca rosetta Ras with GDP bound | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Kondo, Y, Gee, C.L, Kuriyan, J. | | 登録日 | 2017-07-05 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
|
|
5VCU
 | |
5V9O
 | | KRAS G12C inhibitor | | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Westover, K, Lu, J. | | 登録日 | 2017-03-23 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | | 主引用文献 | Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.
Cell Chem Biol, 24, 2017
|
|
5WDP
 | | H-Ras mutant L120A bound to GMP-PNP at 277K | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | | 登録日 | 2017-07-05 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
|
|
5WLB
 | | KRas G12V, bound to GppNHp and miniprotein 225-15a/b | | 分子名称: | 225-15 a, 225-15 b, GTPase KRas, ... | | 著者 | Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. | | 登録日 | 2017-07-26 | | 公開日 | 2018-01-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5WPL
 | | KRas G12V, bound to GppNHp and miniprotein 225-11 | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L. | | 登録日 | 2017-08-05 | | 公開日 | 2018-01-03 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5WHE
 | | KRas G12V/D38P, bound to GppNHp and miniprotein 225-11 | | 分子名称: | CALCIUM ION, GTPase KRas, MAGNESIUM ION, ... | | 著者 | Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. | | 登録日 | 2017-07-16 | | 公開日 | 2018-01-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5WHA
 | | KRas G12V, bound to GDP and miniprotein 225-11 | | 分子名称: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. | | 登録日 | 2017-07-16 | | 公開日 | 2018-01-03 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5WHB
 | | KRas G12V, bound to GDP and miniprotein 225-11(A30R) | | 分子名称: | CALCIUM ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Shim, S.Y, McGee, J.H, Lee, S.-J, Verdine, G.L. | | 登録日 | 2017-07-16 | | 公開日 | 2018-01-03 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5V71
 | | KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder | | 分子名称: | 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Westover, K, Lu, J. | | 登録日 | 2017-03-17 | | 公開日 | 2017-08-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.228 Å) | | 主引用文献 | KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry.
Structure, 25, 2017
|
|
5VBM
 | | Crystal Structure of Small Molecule Disulfide 2C07 Bound to K-Ras Cys Light M72C GDP | | 分子名称: | 1-(4-methoxyphenyl)-N-(3-sulfanylpropyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | | 著者 | Gentile, D.R, Jenkins, M.L, Moss, S.M, Burke, J.E, Shokat, K.M. | | 登録日 | 2017-03-29 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States.
Cell Chem Biol, 24, 2017
|
|
5X9S
 | | Crystal structure of fully modified H-Ras-GppNHp | | 分子名称: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | | 著者 | Matsumoto, S, Ke, H, Murashima, Y, Taniguchi-Tamura, H, Miyamoto, R, Yoshikawa, Y, Kumasaka, T, Mizohata, E, Edamatsu, H, Kataoka, T. | | 登録日 | 2017-03-09 | | 公開日 | 2017-08-30 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural basis for intramolecular interaction of post-translationally modified H-RasGTP prepared by protein ligation
FEBS Lett., 591, 2017
|
|
5XC5
 | | Crystal structure of Acanthamoeba polyphaga mimivirus Rab GTPase in complex with GTP | | 分子名称: | ACETATE ION, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Ku, B, You, J.A, Kim, S.J. | | 登録日 | 2017-03-22 | | 公開日 | 2017-10-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.398 Å) | | 主引用文献 | Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase
Arch. Virol., 162, 2017
|
|
5WPM
 | | KRas G12V, bound to GppNHp and miniprotein 225-11(A30R) | | 分子名称: | GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... | | 著者 | Lee, S.-J, Shim, S.Y, McGee, J.H, Verdine, G.L. | | 登録日 | 2017-08-05 | | 公開日 | 2018-01-03 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Exceptionally high-affinity Ras binders that remodel its effector domain.
J. Biol. Chem., 293, 2018
|
|
5WDR
 | | Choanoflagellate Salpingoeca rosetta Ras with GMP-PNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Ras protein, ... | | 著者 | Kondo, Y, Gee, C.L, Kuriyan, J. | | 登録日 | 2017-07-05 | | 公開日 | 2017-07-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Deconstruction of the Ras switching cycle through saturation mutagenesis.
Elife, 6, 2017
|
|
5XR4
 | |
5XR7
 | |
