5US4

Crystal structure of human KRAS G12D mutant in complex with GDP

Summary for 5US4

Entry DOI	10.2210/pdb5us4/pdb
Related	5UQW 5USJ
Descriptor	GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	kras, gtpase, hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
Total number of polymer chains	2
Total formula weight	44121.53
Authors	Tran, T.,Kaplan, A.,Stockwell, B.R.,Tong, L. (deposition date: 2017-02-13, release date: 2017-03-22, Last modification date: 2024-03-06)
Primary citation	Welsch, M.E.,Kaplan, A.,Chambers, J.M.,Stokes, M.E.,Bos, P.H.,Zask, A.,Zhang, Y.,Sanchez-Martin, M.,Badgley, M.A.,Huang, C.S.,Tran, T.H.,Akkiraju, H.,Brown, L.M.,Nandakumar, R.,Cremers, S.,Yang, W.S.,Tong, L.,Olive, K.P.,Ferrando, A.,Stockwell, B.R. Multivalent Small-Molecule Pan-RAS Inhibitors. Cell, 168:878-889.e29, 2017 Cited by PubMed: 28235199 DOI: 10.1016/j.cell.2017.02.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.83 Å)

Structure validation