5V9L

KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder

Summary for 5V9L

• Entry DOI: 10.2210/pdb5v9l/pdb
• Related: 5V9O
• Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: kras mutant inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 3
• Total formula weight: 60678.71

Authors

Westover, K.,Lu, J. (deposition date: 2017-03-23, release date: 2017-08-23, Last modification date: 2023-10-04)

• Primary citation: Zeng, M.,Lu, J.,Li, L.,Feru, F.,Quan, C.,Gero, T.W.,Ficarro, S.B.,Xiong, Y.,Ambrogio, C.,Paranal, R.M.,Catalano, M.,Shao, J.,Wong, K.K.,Marto, J.A.,Fischer, E.S.,Janne, P.A.,Scott, D.A.,Westover, K.D.,Gray, N.S.; Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.; Cell Chem Biol, 24:1005-1016.e3, 2017; PubMed: 28781124; DOI: 10.1016/j.chembiol.2017.06.017

Experimental method

X-RAY DIFFRACTION (1.981 Å)