5V9L
KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GTPase KRas | polymer | 169 | 19245.7 | 3 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | D, G, J (A, B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 3 | E, H, K (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | F, I, L (A, B, C) | N~3~-[6-chloro-7-(2-fluorophenyl)-4-(4-propanoylpiperazin-1-yl)quinazolin-2-yl]-N,N-dimethyl-beta-alaninamide | non-polymer | 513.0 | 3 | Chemie (91D) | |||
| 5 | M, N, O (A, B, C) | water | water | 18.0 | 240 | Chemie (HOH) |
Sequence modifications
A, B, C: 1 - 168 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57737.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2941.5 | |
| All* | Total formula weight | 60678.7 |
