5WPM
KRas G12V, bound to GppNHp and miniprotein 225-11(A30R)
Summary for 5WPM
Entry DOI | 10.2210/pdb5wpm/pdb |
Descriptor | GTPase KRas, Ras binding peptide, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total) |
Functional Keywords | inhibitor, complex, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 27357.89 |
Authors | Lee, S.-J.,Shim, S.Y.,McGee, J.H.,Verdine, G.L. (deposition date: 2017-08-05, release date: 2018-01-03, Last modification date: 2018-03-14) |
Primary citation | McGee, J.H.,Shim, S.Y.,Lee, S.J.,Swanson, P.K.,Jiang, S.Y.,Durney, M.A.,Verdine, G.L. Exceptionally high-affinity Ras binders that remodel its effector domain. J. Biol. Chem., 293:3265-3280, 2018 Cited by PubMed: 29282294DOI: 10.1074/jbc.M117.816348 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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