5V71
KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder
Summary for 5V71
Entry DOI | 10.2210/pdb5v71/pdb |
Descriptor | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | kras, covalent inhibitor, quinazoline based, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 6 |
Total formula weight | 120672.54 |
Authors | Westover, K.,Lu, J. (deposition date: 2017-03-17, release date: 2017-08-23, Last modification date: 2023-10-04) |
Primary citation | Lu, J.,Harrison, R.A.,Li, L.,Zeng, M.,Gondi, S.,Scott, D.,Gray, N.S.,Engen, J.R.,Westover, K.D. KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry. Structure, 25:1442-1448.e3, 2017 Cited by PubMed: 28781083DOI: 10.1016/j.str.2017.07.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.228 Å) |
Structure validation
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