5V71
KRAS G12C in bound to quinazoline based switch II pocket (SWIIP) binder
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | GTPase KRas | polymer | 169 | 19245.7 | 6 | UniProt (P01116) Pfam (PF00071) | Homo sapiens (Human) | K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras |
| 2 | G, J, M, P, S... (A, B, C, D, E...) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 6 | Chemie (GDP) | |||
| 3 | H, K, N, Q, T... (A, B, C, D, E...) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) | |||
| 4 | I, L, O, R, U... (A, B, C, D, E...) | 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one | non-polymer | 398.9 | 6 | Chemie (8ZG) | |||
| 5 | AA, BA, CA, DA, Y... (C, D, E, F, A...) | water | water | 18.0 | 373 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F: 1 - 168 (UniProt: P01116)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Cys 12 | Gly 12 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 115474.3 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 5198.2 | |
| All* | Total formula weight | 120672.5 |
